Integrated Energy and Catalyst Thermal Management for Plug-In Hybrid Electric Vehicles

With plug-in hybrid electric vehicles (PHEVs), the catalyst temperature is below the light-off temperature due to reduced engine load, extended engine off period, and frequent engine on/off shifting. The conversion efficiency of a three-way catalyst (TWC) and tailpipe emissions were proven to depend heavily on the temperature of the catalyst. The existing energy management strategy (EMS) of the PHEVs focuses on the improvement of fuel efficiency and emissions based on hot engine characteristics, but neglects the effect of catalyst temperature on tailpipe emissions. This paper presents a new EMS that incorporates a catalyst thermal management method. First, an additional cost is established to implement additional constraints on catalyst temperature, and then the global cost function is created using this additional cost and the fuel consumption. Second, we find the global optimal solution using Pontryagin’s minimum principle method, which provides an optimal control policy and state trajectories. Then, based on the analysis of the optimal control policy, an engine on/off filter (eng on/off filter) is introduced to command the engine on/off shifting. This filter plays an important role in adjusting both the energy and catalyst thermal management strategy for PHEVs. Finally, a practical approach based on the eng on/off filter is developed, and a genetic algorithm is applied to optimize the time constants of this filter. Simulation results demonstrate that the proposed approach‘s fuel consumption increased slightly, but the tailpipe emissions of HC (hydrocarbons), CO (carbon monoxide) and NOx (nitrogen oxide) significantly decreased compared with the standard approach

Energy Management for Plug-In Hybrid Electric Vehicle Based on Adaptive Simplified-ECMS

When searching for the optimal solution, Equivalent Consumption Minimum Strategy (ECMS) has to calculate and compare the total equivalent fuel rate of huge candidates covered all over the control domain for each time instant. Therefore, this strategy still has a heavy computation burden problem; it is a challenge for ECMS to be implemented online for real-time control. To reduce ECMS’s calculation load, this paper proposes an adaptive Simplified-ECMS-based strategy for a parallel plug-in hybrid electric vehicle (PHEV). A convex piecewise function is applied to fit the total equivalent fuel rate with respect to the motor torque, which is the control variable. Then, the ECMS problem is simplified to calculate and compare only five candidates’ total equivalent fuel rate to determine the optimal torque distribution. Particle swarm optimization (PSO) algorithm is applied to optimize the equivalent factor, and the MAPs of this factor under different driving cycles, driving distances and initial SOC are obtained. Based on this, the adaptive Simplified-ECMS-based strategy is proposed. Simulations were performed, and the results show that the Simplified-ECMS-based strategy can obviously shorten the calculation time compared to ECMS-based strategy, and the adaptive Simplified-ECMS-based strategy can decrease fuel consumption of plug-in hybrid electric vehicle by 16.43% under the testing driving cycle, compared to CD-CS-based strategy. A road test on the prototype vehicle is conducted and the effectiveness of the Simplified-ECMS-based strategy is validated by the test data

The research progress on the role of FMRP in the pathogenesis of tumors

Fragile X mental retardation protein (FMRP) is a selective RNA-binding protein that is highly expressed in neurons and influences cytoskeletal remodeling, cell-cell signal transduction and interactions. Patients with fragile X syndrome display FMRP deficiency and a lower risk of cancers. However, the specific function of FMRP and the underlying mechanisms are not clear. Evidence indicates the involvements of FMRP in multiple processes of malignant development, including tumor cell migration, invasion, apoptosis, proliferation and metastasis. In addition, FMRP is associated with the occurrence, development and prognosis of tumors. In this paper, we review the progress on the role of FMRP in the pathogenesis of tumors, exploring more potential biomarkers of tumors and new therapeutic targets

Significance of CTC and CTEC values in the peripheral blood of subjects with skin tumors

Objective To investigate the clinical utility of identifying circulating tumor cells (CTC) and circulating tumorigenic endothelial cells (CTEC) in skin malignancies. Methods Subtraction enrichment-immunostaining and fluorescence in situ hybridization (SE-iFISH) were used to detect the number of CTC and CTEC in the peripheral blood of 5 patients with skin tumor (tumor group) and 14 healthy individuals (healthy controls), and the detection rate was calculated. The subtype characteristics of CTC/CTEC and the correlation between the number of CTC/CTEC and the clinical characteristics of the patients were analyzed. Results The positive rates of CTC and CTEC in the tumor group were 100%. The average CTC were (6.93±8.18) /mL and CTEC were (1.60±1.03) /mL in the peripheral blood of the tumor group. The positive rates of CTC and CTEC in the healthy controls were both 64%. The average CTC were (0.19±0.21) /mL, and CTEC were (0.30±0.33) /mL in the peripheral blood of the healthy controls. Patients with larger diameter of tumor, lymph node metastasis, and clinical stages of III and IV had higher levels of CTC and CTEC; Large CTC accounted for 88.46% (184/208) of the total tumor cells, while large CTEC accounted for 81.25% (39/48) of the total tumor cells, which mainly were ≥ pentaploid CTC and CTEC. Conclusions Using SE-iFISH, the detection rates of CTC/CTEC are high in patients with skin tumors. The amounts of CTC and CTEC are correlated with the clinical features of patients. A higher proportion of CTC and CTEC is large multiploid cells in peripheral blood of subjects with skin tumors

Expression of FMRP in cutaneous malignant melanoma and its correlation with hematologic ratios

Objective To investigate the expression of fragile X mental retardation protein (FMRP) in Chinese patients with malignant melanoma and its correlation with hematologic ratios. Methods Lesional skin samples were collected from 23 Chinese with malignant melanoma (melanoma group), and skin samples from 10 normal subjects served as controls (normal skin group). The expression of FMRP was observed using immunohistochemical(IHC) staining, and two scoring methods (H-Score and IRS) were used to evaluate the expression levels. The relationship between FMRP and different pathological grades and stages of malignant melanoma was assessed. The association of FMRP with some hematological ratios, such as neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR) and systemic inflammatory markers (SIM) in patients with malignant melanoma were analyzed. Results The expression levels of FMRP in the melanoma were significantly higher than that in the normal skin (P0.05). Expression levels of FMRP were positively correlated with NLR and SIM, while negatively correlated with LMR. Conclusions FMRP is highly expressed in cutaneous malignant melanoma and its expression levels are significantly correlated with NLR, SIM, and LMR

A case of trichilemmal cyst

A case of trichilemmal cysts is reported. A 31-year-old man presented with a 5-year history of nodule on his back with enlargement, pain and itching for 1 month. Dermatological examination showed erythema and erythematous plaques scattered on the trunk and extremities, covered with a small amount of silvery white scales. A demarcated exophytic tumor sized 2 cm×3 cm in dark red color was seen on the back, with telangiectasia on the surface. The tumor was slightly soft and tenderness (+) with poor mobility. No erosion or ulceration was observed. Histopathological examination showed a dermal cyst, which wall was composed of stratified squamous cells, and the content of cyst was keratin with focal calcification. The patient was diagnosed with trichilemmal cyst. Complete resection was given. No recurrence was observed over 4 months of follow-up