Multi3NLU++: A Multilingual, Multi-Intent, Multi-Domain Dataset for Natural Language Understanding in Task-Oriented Dialogue

Task-oriented dialogue (ToD) systems have been widely deployed in many industries as they deliver more efficient customer support. These systems are typically constructed for a single domain or language and do not generalise well beyond this. To support work on Natural Language Understanding (NLU) in ToD across multiple languages and domains simultaneously, we constructed Multi3NLU++, a multilingual, multi-intent, multi-domain dataset. Multi3NLU++ extends the English-only NLU++ dataset to include manual translations into a range of high, medium, and low resource languages (Spanish, Marathi, Turkish and Amharic), in two domains (banking and hotels). Because of its multi-intent property, Multi3NLU++ represents complex and natural user goals, and therefore allows us to measure the realistic performance of ToD systems in a varied set of the world's languages. We use Multi3NLU++ to benchmark state-of-the-art multilingual models for the NLU tasks of intent detection and slot labeling for ToD systems in the multilingual setting. The results demonstrate the challenging nature of the dataset, particularly in the low-resource language setting, offering ample room for future experimentation in multi-domain multilingual ToD setups

MULTI3NLU++: A Multilingual, Multi-Intent, Multi-Domain Dataset for Natural Language Understanding in Task-Oriented Dialogue

Task-oriented dialogue (TOD) systems have been widely deployed in many industries as they deliver more efficient customer support. These systems are typically constructed for a single domain or language and do not generalise well beyond this. To support work on Natural Language Understanding (NLU) in TOD across multiple languages and domains simultaneously, we constructed MULTI3NLU++, a multilingual, multi-intent, multi-domain dataset. MULTI3NLU++ extends the English only NLU++ dataset to include manual translations into a range of high, medium, and low resource languages (Spanish, Marathi, Turkish and Amharic), in two domains (BANKING and HOTELS). Because of its multi-intent property, MULTI3NLU++ represents complex and natural user goals, and therefore allows us to measure the realistic performance of TOD systems in a varied set of the world's languages. We use MULTI3NLU++ to benchmark state-of-the-art multilingual models for the NLU tasks of intent detection and slot labelling for TOD systems in the multilingual setting. The results demonstrate the challenging nature of the dataset, particularly in the low-resource language setting, offering ample room for future experimentation in multi-domain multilingual TOD setups.Comment: ACL 2023 (Findings) Camera Read

Differences in Acinetobacter baumannii Strains and Host Innate Immune Response Determine Morbidity and Mortality in Experimental Pneumonia

Despite many reports documenting its epidemicity, little is known on the interaction of Acinetobacter baumannii with its host. To deepen our insight into this relationship, we studied persistence of and host response to different A. baumannii strains including representatives of the European (EU) clones I–III in a mouse pneumonia model. Neutropenic mice were inoculated intratracheally with five A. baumannii strains and an A. junii strain and at several days morbidity, mortality, bacterial counts, airway inflammation, and chemo- and cytokine production in lungs and blood were determined. A. baumannii RUH875 and RUH134 (EU clone I and II, respectively) and sporadic strain LUH8326 resulted in high morbidity/mortality, whereas A. baumannii LUH5875 (EU clone III, which is less widespread than clone I and II) caused less symptoms. A. baumannii type strain RUH3023T and A. junii LUH5851 did not cause disease. All strains, except A. baumannii RUH3023T and A. junii LUH5851, survived and multiplied in the lungs for several days. Morbidity and mortality were associated with the severity of lung pathology and a specific immune response characterized by low levels of anti-inflammatory (IL-10) and specific pro-inflammatory (IL-12p40 and IL-23) cytokines at the first day of infection. Altogether, a striking difference in behaviour among the A. baumannii strains was observed with the clone I and II strains being most virulent, whereas the A. baumannii type strain, which is frequently used in virulence studies appeared harmless

Karnak – Sanctuaires osiriens (2022)

Données scientifiques produites :https://www.ifao.egnet.net/archeologie/karnak/. Dans le cadre de l’opération archéologique et épigraphique dirigée par Laurent Coulon et Cyril Giorgi, sont fouillées trois chapelles (XXVe-XXVIe dynasties) situées au nord-ouest du grand temple d’Amon de Karnak, entre la grande salle hypostyle et le temple de Ptah, respectivement consacrées à Osiris Neb-ânkh, Osiris Ounnefer Neb-djefaou et Osiris Ounnefer. I. Études archéologiques, fouilles et travaux de restaur..

Shogaol-huprine hybrids: Dual antioxidant and anticholinesterase agents with beta-amyloid and tau anti-aggregating properties

Multitarget compounds are increasingly being pursued for the effective treatment of complex diseases. Herein, we describe the design and synthesis of a novel class of shogaolhuprine hybrids, purported to hit several key targets involved in Alzheimer"s disease. The hybrids have been tested in vitro for their inhibitory activity against human acetylcholinesterase and butyrylcholinesterase and antioxidant activity (ABTS.+, DPPH and Folin-Ciocalteu assays), and in intact Escherichia coli cells for their Aβ42 and tau anti-aggregating activity. Also, their brain penetration has been assessed (PAMPA-BBB assay). Even though the hybrids are not as potent AChE inhibitors or antioxidant agents as the parent huprine Y and [4]-shogaol, respectively, they still exhibit very potent anticholinesterase and antioxidant activities and are much more potent Aβ42 and tau anti-aggregating agents than the parent compounds. Overall, the shogaolhuprine hybrids emerge as interesting brain permeable multitarget anti-Alzheimer leads

Association of Lipidome Remodeling in the Adipocyte Membrane with Acquired Obesity in Humans

The authors describe a new approach to studying cellular lipid profiles and propose a compensatory mechanism that may help maintain the normal membrane function of adipocytes in the context of obesity

Revisions to the Classification, Nomenclature, and Diversity of Eukaryotes

This revision of the classification of eukaryotes follows that of Adl et al., 2012 [J. Euk. Microbiol. 59(5)] and retains an emphasis on protists. Changes since have improved the resolution of many nodes in phylogenetic analyses. For some clades even families are being clearly resolved. As we had predicted, environmental sampling in the intervening years has massively increased the genetic information at hand. Consequently, we have discovered novel clades, exciting new genera, and uncovered a massive species level diversity beyond the morphological species descriptions. Several clades known from environmental samples only have found their home. Sampling soils, deeper marine waters, and the deep sea will continue to fill us with surprises. The main changes in this revision are the confirmation that eukaryotes form at least two domains, the loss of monophyly in the Exavata, robust support for the Haptista and Cryptista. We provide suggested primer sets for DNA sequences from environmental samples that are effective for each clade. We have provided a guide to trophic functional guilds in an appendix, to facilitate the interpretation of environmental samples. This revision of the classification of eukaryotes updates that of the International Society of Protistologists (Adl et al., 2012). Since then, there has been a massive increase in DNA sequence information of phylogenetic relevance from environmental samples. We now have a much better sense of the undescribed biodiversity in our environment (Pawlowski et al., 2012; de Vargas et al., 2015). While significant, it still remains a partial estimation as several continents and soils in general are poorly sampled, and the deeper ocean is hard to reach. This new data clarified phylogenetic relationships and the new information is incorporated in this revision