3% diquafosol sodium eye drops in Chinese patients with dry eye: a phase IV study

IntroductionThe efficacy and safety of 3% diquafosol sodium eye drops in Chinese patients with dry eye in the real-world setting remains unclear.Methods3099 patients with dry eye symptoms were screened according to Asia Dry Eye Society latest recommendation. Among them, 3000 patients were enrolled for a phase IV study. We followed up with multiple clinical characteristics including corneal fluorescein staining, tear break up time, Schirmer’s tests, visual acuity, intraocular pressure, and others. The follow ups were performed at baseline, 2 weeks and 4 weeks after treatment.ResultsBased on the results of corneal fluorescein staining and tear break up time, all age and gender subgroups exhibited obvious alleviation of the symptoms among the patients with dry eye, and the data in elderly group showed the most significant alleviation. All the adverse drug reactions (ADRs, 6.17%) were recorded, among which 6% local ocular ADRs were included. Meanwhile, mild ADRs (91.8%) accounted for the most. Most of the ADRs (89.75%) got a quick and full recovery, with an average time at 15.6 days. 1.37% of patients dropped out of the study due to ADRs.DiscussionThe use of 3% diquafosol sodium eye drop is effective and safe in the treatment of dry eye, with a low incidence of ADRs showing mild symptoms. This trial was registered at Chinese Clinical Trial Registry ID: ChiCTR1900021999 (Registration Date: 19/03/2019)

Using eDNA to detect the distribution and density of invasive crayfish in the Honghe-Hani rice terrace World Heritage site

The Honghe-Hani landscape in China is a UNESCO World Natural Heritage site due to the beauty of its thousands of rice terraces, but these structures are in danger from the invasive crayfish Procambarus clarkii. Crayfish dig nest holes, which collapse terrace walls and destroy rice production. Under the current control strategy, farmers self-report crayfish and are issued pesticide, but this strategy is not expected to eradicate the crayfish nor to prevent their spread since farmers are not able to detect small numbers of crayfish. Thus, we tested whether environmental DNA (eDNA) from paddy-water samples could provide a sensitive detection method. In an aquarium experiment, Real-time Quantitative polymerase chain reaction (qPCR) successfully detected crayfish, even at a simulated density of one crayfish per average-sized paddy (with one false negative). In a field test, we tested eDNA and bottle traps against direct counts of crayfish. eDNA successfully detected crayfish in all 25 paddies where crayfish were observed and in none of the 7 paddies where crayfish were absent. Bottle-trapping was successful in only 68% of the crayfish-present paddies. eDNA concentrations also correlated positively with crayfish counts. In sum, these results suggest that single samples of eDNA are able to detect small crayfish populations, but not perfectly. Thus, we conclude that a program of repeated eDNA sampling is now feasible and likely reliable for measuring crayfish geographic range and for detecting new invasion fronts in the Honghe Hani landscape, which would inform regional control efforts and help to prevent the further spread of this invasive crayfish

Quantifying the Spatio-Temporal Variations and Impacts of Factors on Vegetation Water Use Efficiency Using STL Decomposition and Geodetector Method

Water use efficiency of vegetation (WUE), the ratio of carbon gain to water loss, is a valid indicator to describe the photosynthetic carbon–water coupling relationship. Understanding how and why WUE changes are essential for regional ecological conservation. However, the impacts of various factors and their interactions on the spatial variation of WUE remain uncertain in the arid land of Northwest China. Here, we selected the Qilian Mountains (QM) and Hexi Corridor (HC) as the study areas. Supported by the Google Earth Engine, we explored the spatio-temporal variations of WUE in QM and HC for 2002–2021 using STL decomposition (a seasonal-trend decomposition procedure), trend analysis, and the Hurst index. Then, the Geodetector method was applied to quantify impacts of geographical and eco-meteorological factors on the spatial variation of WUE. The WUE in HC was higher than that in QM. Interestingly, the opposite longitude zonality characteristics are shown in the QM and HC. In QM, the WUE showed an upward trend with longitude increasing, while a downward trend with longitude increasing in the oases of HC. The WUE of cropland was the highest (1.15 ± 0.35 gC kg−1 H2O), and that of alpine vegetation was the lowest (0.2 ± 0.15 gC kg−1 H2O). WUE showed a decreasing trend across the study area, almost certainly due to a drop from May to July during 2002–2021. The air temperature is the dominant factor influencing the spatial variation of WUE. In addition, the interaction of any two factors is greater than the independent influence of either factor alone. The Geodetector method proved to be effective for quantifying the impact of complex multi-factors on the spatial variation of WUE. This study provides a new technical scheme to analyze the spatio-temporal pattern and quantify the impact of multi-factors on the spatial variation of WUE. These findings aid in understanding underlying mechanisms of WUE variation and thereby will be beneficial for clarifying the response of vegetation to climate change

Highly-Responsive Broadband Photodetector Based on Graphene-PTAA-SnS₂ Hybrid

The development of wearable systems stimulate the exploration of flexible broadband photodetectors with high responsivity and stability. In this paper, we propose a facile liquid-exfoliating method to prepare SnS2 nanosheets with high-quality crystalline structure and optoelectronic properties. A flexible photodetector is fabricated using the SnS2 nanosheets with graphene-poly[bis(4-phenyl) (2,4,6-trimethylphenyl) amine (PTAA) hybrid structure. The liquid-exfoliated SnS2 nanosheets enable the photodetection from ultraviolet to near infrared with high responsivity and detectivity. The flexible broadband photodetector demonstrates a maximum responsivity of 1 × 105 A/W, 3.9 × 104 A/W, 8.6 × 102 A/W and 18.4 A/W under 360 nm, 405 nm, 532 nm, and 785 nm illuminations, with specific detectivity up to ~1012 Jones, ~1011 Jones, ~109 Jones, and ~108 Jones, respectively. Furthermore, the flexible photodetector exhibits nearly invariable performance over 3000 bending cycles, rendering great potentials for wearable applications

Honghe Hani Terrace landscape in Yunnan, China, 30 March 2016.

<p>Honghe Hani Terrace landscape in Yunnan, China, 30 March 2016.</p