2 research outputs found
Compartment-specific Synthesis of Phosphatidylethanolamine Is Required for Normal Heavy Metal Resistance
The enzyme Psd2 catalyzes endosomal synthesis of the phospholipid PE. While this pool of PE represents a minority of total cellular PE, function of Psd2 is required for normal activity of the vacuolar ABC transporter Ycf1. Psd2 controls vacuolar PE levels by acting at the level of the endosome
Gex1 is a yeast glutathione exchanger that interferes with pH and redox homeostasis
Gex1 is a glutathione exchanger mostly found at the vacuolar membrane. The expression of Gex1 and Gex2 is induced under conditions of iron depletion, and Gex1 is regulated principally by the iron transcription factor Aft2. Loss of or high Gex1/2 activity modulates PKA and MAPK signaling events