A EFICÁCIA DAS REDES DE COOPERAÇÃO JURÍDICA DIRETA NO COMBATE À CORRUPÇÃO TRANSNACIONAL E SUA CONCRETIZAÇÃO PELO SISTEMA PROCESSUAL BRASILEIRO: NOTAS SOBRE A OPERAÇÃO LAVA-JATO.

Inseridos na área de concentração Justiça, Processo e Constituição, na linha de pesquisa Processo, Constitucionalidade e Tutela de Direitos Existenciais e Patrimoniais do Mestrado em Direito Processual da Universidade Federal do Espírito Santo, os estudos foram desenvolvidos a partir de contribuições dos Grupos de Pesquisa intitulados O Direito Internacional e o Labirinto da Codificação e Limites e Extensão da Jurisdição Internacional Brasileira. A partir da premissa da problemática da corrupção, compreendida como fenômeno de mercadejo da função pública visando à obtenção de vantagens indevidas, busca-se combater a expansão de suas práticas na comunidade globalizada, sob a ótica procedimental da realização da cooperação jurídica internacional. Por meio do método indutivo de investigação, adota-se como referencial particular o recorte fático extraído da Ação Penal nº 5036528-23.2015.4.04.7000, em trâmite perante a 13ª Vara da Seção Judiciária Federal do Paraná, com o objetivo de verificar a aplicação das redes transnacionais para sustentar o intercâmbio de dados, informações e elementos de prova, in casu. A partir da análise do caso concreto, propõe-se a construção de um conhecimento geral sobre a eficácia da aplicação de instrumentos de cooperação penal para o enfrentamento da corrupção em dimensão transnacional e sua concretização pelo sistema processual brasileiro, com especial enfoque nas redes de cooperação direta. Assentada na linha de pensamento do Pluralismo Jurídico Transnacional, adota-se a concepção do Direito Global fundada na formação de discursos e redes de comunicação, enquanto o reflexo de arranjos nos quais se associam multifaces jurídicas e se agregam feixes normativos emitidos a partir de diversificados corpos comunicantes, integrando um espectro de transnacionalidade. O estudo se baseia na ação coletiva de redes transnacionais e de arranjos cooperativos entre autoridades reguladoras nacionais. Outrossim, são lançadas as bases especificamente no necessário respeito aos direitos fundamentais da pessoa humana e sua assunção como limite e paradigma democrático da atuação das redes de cooperação para combater práticas delituosas na comunidade global hodierna. Por fim, serão realizados apontamentos acerca da confirmação ou não da hipótese da pesquisa, para o fim de determinar se tais redes são eficazes no combate à corrupção e se são concretizadas no sistema processual brasileiro, traçando as respectivas notas sobre a aplicação das redes de cooperação direta na Operação Lava Jato. Palavras-chave: Corrupção. Transnacionalidade. Cooperação Jurídica Internacional. Redes de Cooperação Direta. Processo Penal Internacional

Avaliação de plantas de sorgo silageiro 2022/2023.

ResumoODS 2

Using high-resolution LiDAR-derived canopy structure and topography to characterise hibernaculum locations of the hazel dormouse

This is the final version. Available on open access from Springer via the DOI in this recordData availability: The data that support the findings of this study are available from the corresponding author, LG, upon reasonable request.The hazel dormouse is predominantly an arboreal species that moves down to the ground to hibernate in the autumn in temperate parts of its distributional ranges at locations not yet well understood. The main objective of this study is to test whether environmental characteristics surrounding hazel dormouse hibernacula can be identified using high-resolution remote sensing and data collected in situ. To achieve this, remotely sensed variables, including canopy height and cover, topographic slope, sky view, solar radiation and cold air drainage, were modelled around 83 dormouse hibernacula in England (n = 62) and the Netherlands (n = 21), and environmental characteristics that may be favoured by pre-hibernating dormice were identified. Data on leaf litter depth, temperature, canopy cover and distance to the nearest tree were collected in situ and analysed at hibernaculum locations in England. The findings indicated that remotely sensed data were effective in identifying attributes surrounding the locations of dormouse hibernacula and when compared to in situ information, provided more conclusive results. This study suggests that remotely sensed topographic slope, canopy height and sky view have an influence on hazel dormice choosing suitable locations to hibernate; whilst in situ data suggested that average daily mean temperature at the hibernaculum may also have an effect. Remote sensing proved capable of identifying localised environmental characteristics in the wider landscape that may be important for hibernating dormice. This study proposes that this method can provide a novel progression from habitat modelling to conservation management for the hazel dormouse, as well as other species using habitats where topography and vegetation structure influence fine-resolution favourability.People’s Trust for Endangered Species (PTES

R534C mutation in hERG causes a trafficking defect in iPSC-derived cardiomyocytes from patients with type 2 long QT syndrome

Patient-specific cardiomyocytes obtained from induced pluripotent stem cells (CM-iPSC) offer unprecedented mechanistic insights in the study of inherited cardiac diseases. The objective of this work was to study a type 2 long QT syndrome (LQTS2)-associated mutation (c.1600C > T in KCNH2, p.R534C in hERG) in CM-iPSC. Peripheral blood mononuclear cells were isolated from two patients with the R534C mutation and iPSCs were generated. In addition, the same mutation was inserted in a control iPSC line by genome editing using CRISPR/Cas9. Cells expressed pluripotency markers and showed spontaneous differentiation into the three embryonic germ layers. Electrophysiology demonstrated that action potential duration (APD) of LQTS2 CM-iPSC was significantly longer than that of the control line, as well as the triangulation of the action potentials (AP), implying a longer duration of phase 3. Treatment with the IKr inhibitor E4031 only caused APD prolongation in the control line. Patch clamp showed a reduction of IKr on LQTS2 CM-iPSC compared to control, but channel activation was not significantly affected. Immunofluorescence for hERG demonstrated perinuclear staining in LQTS2 CM-iPSC. In conclusion, CM-iPSC recapitulated the LQTS2 phenotype and our findings suggest that the R534C mutation in KCNH2 leads to a channel trafficking defect to the plasma membrane.Fil: Mesquita, Fernanda C. P.. Universidade Federal do Rio de Janeiro; BrasilFil: Arantes, Paulo C.. Universidade Federal do Rio de Janeiro; BrasilFil: Kasai Brunswick, Tais H.. Universidade Federal do Rio de Janeiro; BrasilFil: Araujo, Dayana S.. Universidade Federal do Rio de Janeiro; BrasilFil: Gubert, Fernanda. Universidade Federal do Rio de Janeiro; BrasilFil: Monnerat, Gustavo. Universidade Federal do Rio de Janeiro; BrasilFil: Silva dos Santos, Danúbia. Universidade Federal do Rio de Janeiro; BrasilFil: Neiman, Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Leitão, Isabela C.. Universidade Federal do Rio de Janeiro; BrasilFil: Barbosa, Raiana A. Q.. Universidade Federal do Rio de Janeiro; BrasilFil: Coutinho, Jorge L.. National Institute Of Cardiology; BrasilFil: Vaz, Isadora M.. Pontificia Universidad Catolica de Parana; BrasilFil: dos Santos, Marcus N.. Universidade Federal do Rio de Janeiro; BrasilFil: Borgonovo, Tamara. Pontificia Universidad Catolica de Parana; BrasilFil: Cruz, Fernando E. S.. National Institute of Cardiology; BrasilFil: Miriuka, Santiago Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Medei, Emiliano H.. Universidade Federal do Rio de Janeiro; BrasilFil: Campos de Carvalho, Antonio C.. Universidade Federal do Rio de Janeiro; Brasil. National Institute of Cardiology; Brasil. National Institute for Science and Technology in Regenerative Medicine; BrasilFil: Carvalho, Adriana B.. Universidade Federal do Rio de Janeiro; Brasil. National Institute for Science and Technology in Regenerative Medicine; Brasi

Adherence to secondary prophylaxis and disease recurrence in 536 Brazilian children with rheumatic fever

<p>Abstract</p> <p>Background</p> <p>More than 15 million people worldwide have rheumatic fever (RF) and rheumatic heart disease due to RF. Secondary prophylaxis is a critical cost-effective intervention for preventing morbidity and mortality related to RF. Ensuring adequate adherence to secondary prophylaxis for RF is a challenging task. This study aimed to describe the rates of recurrent episodes of RF, quantify adherence to secondary prophylaxis, and examine the effects of medication adherence to the rates of RF in a cohort of Brazilian children and adolescents with RF.</p> <p>Methods</p> <p>This retrospective study took place in the Pediatric Rheumatology outpatient clinic at a tertiary care hospital (Instituto de Puericultura e Pediatria Martagão Gesteira) in Rio de Janeiro, Brazil, and included patients with a diagnosis of RF from 1985 to 2005.</p> <p>Results</p> <p>536 patients with RF comprised the study sample. Recurrent episodes of RF occurred in 88 of 536 patients (16.5%). Patients with a recurrent episode of RF were younger (p < 0.0001), more frequently males (p = 0.003), and less adherent (p < 0.0001) to secondary prophylaxis than patients without RF recurrence. Non-adherence to medication at any time during follow-up was detected in 35% of patients. Rates of non-adherence were higher in the group of patients that were lost to follow-up (42%) than in the group of patients still in follow-up (32%) (p = 0.027). Appointment frequency was inadequate in 10% of patients. Higher rates of inadequate appointment frequency were observed among patients who were eventually lost to follow-up (14.5%) than in patients who were successfully followed-up (8%) (p = 0.022). 180 patients (33.5%) were lost to follow up at some point in time.</p> <p>Conclusions</p> <p>We recommend implementation of a registry, and a system of active search of missing patients in every service responsible for the follow-up of RF patients. Measures to increase adherence to secondary prophylaxis need to be implemented formally, once non-adherence to secondary prophylaxis is the main cause of RF recurrence. Detection of irregularity in secondary prophylaxis or in appointments should be an alert about the possibility of loss of follow-up and closer observation should be instituted.</p