63 research outputs found
Diastereoselective synthesis of highly constrained spiro-β-lactams via the Staudinger reaction using an unsymmetrical bicyclic ketene
Stereoselective cyclopropanation of serine and threonine-derived oxazines to access new morpholine-based scaffolds
Synthesis of an Amide Library Based on the 6,8-Dioxa-3-azabicyclo[3.2.1]octane Scaffold by Direct Aminolysis of Methyl Esters
The dextrorotatory sweet asparagine of Arnaldo Piutti: the original product is conserved in Florence
In 1886, Pasteur presented a note on the work of the Italian chemist Arnaldo Piutti concerning the difference between the two physical isomers (enantiomers) of asparagine. The octahedral crystal of asparagine appeared only as “levorotatory hemihedralism” but, in principle, should also exist as a dextrorotatory asparagine with a symmetric crystalline form. In 1886 Arnaldo Piutti isolated the dextrorotatory asparagines while he was working as an assistant of Ugo Schiff in Florence. He obtained also another unexpected information, of which only Pasteur immediately understood the importance: the dextrorotatory aspargine had a sweet taste. The dextrorotatory sweet asparagine of Arnaldo Piutti is conserved in the Schiff Collection of the Department of Chemistry “Ugo Schiff” at the University of Florence, and is the first compound where a relationship between the optical isomerism of a molecule and a different response of human receptors, in this case the taste, was observed
New Evidence of Similarity between Human and Plant Steroid Metabolism: 5alpha-Reductase Activity in Solanum malacoxylon
Pharmacokinetics of 4-hydroxyandrostenedione in man after intramuscular injection of different formulations and the effect of this drug on plasma aromatizable androgens and 17beta-estradiol concentrations.
Synthesis of 5,6,6-[2H3]finasteride and quantitative determination of finasteride in human plasma at picogram level by an isotope-dilution mass spectrometric method.
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