Il dialogo di civiltà alla luce dell’esperienza kazakistana

La Repubblica del Kazakhstan, che ha acquisito l’indipendenza nel 1991 in seguito alla dissoluzione dell’URSS, è uno dei Paesi più variegati del mondo sotto il profilo della composizione nazionale e religiosa: sul suo vasto territorio si contano infatti oltre 130 gruppi etnici e 40 confessioni all’interno di una popolazione di circa 16 milioni di abitanti. Una realtà che si potrebbe definire tanto complessa quanto poco conosciuta, specialmente in Italia. Il testo si concentra sulla strategia perseguita dal governo kazako (la c.d. unità nella diversità, o in alcuni documenti l’unità attraverso la diversità), che a partire dall’indipendenza si è trovato a governare in piena autonomia su una realtà estremamente eterogenea. La scelta delle autorità è stata quella di puntare sulla costruzione di una identità “kazakistana”, ossia civile, laica e sovranazionale, che ambisce a garantire una convivenza pacifica proponendosi come modello di dialogo fra civiltà. La distinzione tra identità “kazaka” (cioè etnicamente e linguisticamente connotata) e identità “kazakistana” (chiamata ad accogliere popoli diversi sotto una cittadinanza esplicitamente multiculturale) costituisce il cuore di questa strategia

Effect of soda-lime glass on sintering and technological properties of porcelain stoneware tiles

The feasibility of waste glass recycling in ceramic tile production was assessed with special reference to fully vitrified products (porcelain stoneware). Soda-lime float or container glass was introduced, in replacement of sodic feldspar, in typical porcelain stoneware bodies (up to 10% wt) that underwent a laboratory simulation of tilemaking process, with a technological and compositional characterization of both fired and unfired tiles. Soda-lime glass had no significant effect on semi-finished products, but it influenced remarkably the firing behaviour, increasing shrinkage and closed porosity, decreasing open porosity and bulk density, and lowering mechanical and tribological performances. Waste glass promotes a more effective melting of quartz and a partial dissolution of mullite, leading to a more abundant and less viscous liquid phase, which accelerates the sintering kinetics. In conclusion, soda-lime glass can be used in small amounts (5% or less) with tolerable modifications of technological behaviour and performances of porcelain stoneware tiles

Employment, innovation, and interfirm networks

This paper studies the employment impact of business network agreements, an innovative policy instrument introduced in Italy in 2010 to stimulate interfirm cooperation, with the aim of increasing innovative capacity and market competitiveness. We estimate the impact of these networks on employment for a panel of Italian firms using a system generalized method of moments and considering the literature on the employment impact of innovation. We find that networks, which can be interpreted as a form of open innovation, have a positive impact on employment; moreover, this impact appears positively influenced by sectoral and regional heterogeneity of firms and the region\u2019s innovation capacities. Overall, the results suggest that participation in networks where firms share industrial, commercial, and technical knowledge improves firm performance, creating synergies that help firms, especially small and medium-sized enterprises, to manage the growing complexity of knowledge and the fierce competition arising from increasingly globalized markets

The Role of counterions (Mo, Nb, Sb, W) in Cr-, Mn-, Ni- and V-doped rutile ceramic pigments. Part 2. Colour and technological properties

Industrial rutile pigments are manufactured using several chromophores: Cr (giving an orange hue), Mn (tan), Ni (yellow) and V (gray); a second element, the so-called counterion (i.e. Mo, Sb, Nb or W) is always added in order to achieve the desired coloration and/or improve the technological properties (e.g. chemico-physical resistance in ceramic bodies and glazes). The colour of these pigments is determined by both metal-ligand charge transfer (Ti4+ <-> O2-) and crystal field effects (transition metals substituting Ti4+ in octahedral coordination). Though the absorbance bands are broad and frequently overlapped, the UV-vis-NIR spectra suggest the occurrence of Cr3+, Mn2+, Mn3+, Ni2+, V3+, and V4+ as chromophores. Rutile pigments are suitable for through-body (up to 1250 degrees C) and glaze applications (up to 1100 degrees C). The best coloration of porcelain stoneware bodies is achieved with Sb or W as counterions, though the higher stability is ensured by Sb, but in the Ti-Ni-W system. The best glaze colours are accomplished by W-bearing pigments, which however are less stable than Nb- or Sb-containing ones, except than for the V + W coupling. This latter represents a new and very interesting Co-free and Cr-free black pigment for low temperature applications

Beyond ras and braf: Her2, a new actionable oncotarget in advanced colorectal cancer

The human epidermal growth factor receptor 2 (HER2) is a well-established oncogenic driver and a successful therapeutic target in several malignancies, such as breast and gastric cancers. HER2 alterations, including amplification and somatic mutations, have also been detected in a small but not negligible subset of patients affected by advanced colorectal cancer (aCRC). However, to date, there are no available oncotargets in this malignancy beyond RAS and BRAF that are available. Here we present an overview on the present predictive and prognostic role of HER2 expression in aCRC, as well as on its consequent potential therapeutic implications from preclinical investigations towards ongoing trials testing anti-HER2 agents in aCRC. While HER2′ s role as a molecular predictive biomarker for anti-EGFR therapies in CRC is recognized, HER2 prognostic value remains controversial. Moreover, thanks to the impressive and growing body of clinical evidence, HER2 is strongly emerging as a new potential actionable oncotarget in aCRC. In conclusion, in the foreseeable future, HER2-targeted therapeutic strategies may integrate the algorithm of aCRC treatment towards an increasingly tailored therapeutic approach to this disease

Hodgkin lymphoma: A special microenvironment

Classical Hodgkn’s lymphoma (cHL) is one of the most particular lymphomas for the few tumor cells surrounded by an inflammatory microenvironment. Reed-Sternberg (RS) and Hodgkin (H) cells reprogram and evade antitumor mechanisms of the normal cells present in the microenvi-ronment. The cells of microenvironment are essential for growth and survival of the RS/H cells and are recruited through the effect of cytokines/chemokines. We summarize recent advances in gene expression profiling (GEP) analysis applied to study microenvironment component in cHL. We also describe the main therapies that target not only the neoplastic cells but also the cellular components of the background

Clinical relevance of silent red blood cell autoantibodies.

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Effect of waste glass (TV/PC cathodic tube and screen) on technological properties and sintering behaviour of porcelain stoneware tiles

In the present work, the effects of TV and PC cathodic tube and screen glasses additions (5 and 10 wt.%) to a porcelain stoneware body, in replacement of feldspar, were evaluated simulating the tilemaking process. The presence of glass allows to preserve good technological and mechanical properties, complying with the latest requirements of the industrial practice. The sintering pattern of the glass-added bodies, evaluated by hot stage microscopy, is modified according to the different glass amount and typology; in particular, cathodic tube glass when present at 5 wt.% brings about a lowering of the maximum densification temperature and of the activation energy

Low Rates of Pointing in 18-Month-Olds at Risk for Autism Spectrum Disorder and Extremely Preterm Infants: A Common Index of Language Delay?

Infants with an older sibling with an Autism Spectrum Disorder diagnosis (Sibs ASD) are at high risk for language delay (LD) as well as infants born preterm, especially those with an extremely low gestational age (ELGA, GA 64 28 weeks). Gestures play a crucial role in language development and delays in gesture production may have negative cascading effects on it. The present exploratory study examined gesture production in 18-month-old infants with different underlying risks for LD. Seventy monolingual United States infants (41 Sibs ASD with no eventual ASD diagnosis and 29 infants with a typically developing older sibling -Sibs TD) and 40 monolingual Italian infants (20 ELGA without major cerebral damages, congenital malformations or sensory impairments and 20 full-term - FT infants, GA 65 37 weeks) were included. Both groups were followed longitudinally from 18 to 24, 30, and 36 months (corrected for ELGA infants). A 30-minute mother-infant play session with age-appropriate toys was video recorded at 18 months of age. Deictic (requesting, pointing, showing and giving), conventional, and representational gestures spontaneously produced by infants were coded; rate per 10 min was calculated. LD was defined as a score 6410th percentile on the American English or Italian version of the MacArthur-Bates CDI on at least two time points between 18 and 36 months. Fifteen Sibs ASD and 9 ELGA infants were identified as infants with LD. Sibs ASD-LD and Sibs ASD-no LD produced fewer pointing gestures compared to Sibs TD (p = 0.038; p = 0.004); ELGA-LD infants produced significantly fewer pointing gestures than ELGA-no LD (p = 0.024) and FT (p = 0.006) infants. Low rates of pointing at 18 months are a marker of LD in Sibs ASD and ELGA infants. The potential implications of reduced pointing production and characteristics of different populations at risk for LD should be considered for understanding the emergence of LD