Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Pseudomyxoma Peritonei of Appendiceal Origin - 801 Cases from a Single Institution in China

Aim: As more and more centers has published their treatment results ofpseudomyxoma peritonei (PMP) with cytoreductive surgery (CRS) andhyperthermic intraperitoneal chemotherapy (HIPEC), the data from Chinais missing. Myxoma Department of Aerospace Hospital is the biggestcenter treating PMP in China. The purpose of this study is to report theearly and long-term outcomes for PMP from this single center. Methods:801 appendix-derived PMP out of 1008 consecutive patients treated inMyxoma Department of Aerospace Hospital between 2008 and 2019 wereretrospectively analyzed. Results: Complete cytoreductive surgery (CCRS)was achieved in 240 (30%) patients with median PCI of 14(1~39), andthe rest had maximal tumor debulking (MTD), HIPEC was implementedin 96.3% of CCRS and 78.6% of MTD. The major morbidity (gradeIII/IV) was 11.4% and the 30-day operative mortality is 0.7%. The 5-and 10-year OS of CCRS was 76.9% and 64.1%, which is significantlyhigher than MTD (5-, 10-year OS as 36.1%, 27.1%; p20, MTD, high pathologic grade and without HIPECwere independent factors predicting poorer prognosis. Conclusions: CCRS+HIPEC can benefit PMP well with controllable risks. MTD+HIPEC maybenefit PMP as well when CCRS cannot be achieved after fully asscessmentby an experienced peritoneal maglignacy center, but the surgery should beperformed as limited as possible

Pressure-induced emission of cesium lead halide perovskite nanocrystals.

Metal halide perovskites (MHPs) are of great interest for optoelectronics because of their high quantum efficiency in solar cells and light-emitting devices. However, exploring an effective strategy to further improve their optical activities remains a considerable challenge. Here, we report that nanocrystals (NCs) of the initially nonfluorescent zero-dimensional (0D) cesium lead halide perovskite Cs4PbBr6 exhibit a distinct emission under a high pressure of 3.01 GPa. Subsequently, the emission intensity of Cs4PbBr6 NCs experiences a significant increase upon further compression. Joint experimental and theoretical analyses indicate that such pressure-induced emission (PIE) may be ascribed to the enhanced optical activity and the increased binding energy of self-trapped excitons upon compression. This phenomenon is a result of the large distortion of [PbBr6]4- octahedral motifs resulting from a structural phase transition. Our findings demonstrate that high pressure can be a robust tool to boost the photoluminescence efficiency and provide insights into the relationship between the structure and optical properties of 0D MHPs under extreme conditions

Highly frequent PIK3CA amplification is associated with poor prognosis in gastric cancer

<p>Abstract</p> <p>Background</p> <p>The phosphoinositide 3-kinase (PI3K)/Akt pathway plays a fundamental role in cell proliferation and survival in human tumorigenesis, including gastric cancer. <it>PIK3CA </it>mutations and amplification are two major causes of overactivation of this pathway in human cancers. However, until this work, there was no sound investigation on the association of <it>PIK3CA </it>mutations and amplification with clinical outcome in gastric cancer, particularly the latter.</p> <p>Methods</p> <p>Using direct sequencing and real-time quantitative PCR, we examined <it>PIK3CA </it>mutations and amplification, and their association with clinicopathological characteristics and clinical outcome of gastric cancer patients.</p> <p>Results</p> <p><it>PIK3CA </it>mutations and amplification were found in 8/113 (7.1%) and 88/131 (67%) gastric cancer patients, respectively. <it>PIK3CA </it>amplification was closely associated with increased phosphorylated Akt (p-Akt) level. No relationship was found between <it>PIK3CA </it>mutations and clinicopathological characteristics and clinical outcome in gastric cancer. <it>PIK3CA </it>amplification was significantly positively associated with cancer-related death. Importantly, Kaplan-Meier survival curves revealed that the patients with <it>PIK3CA </it>amplification had significantly shorter survival times than the patients without <it>PIK3CA </it>amplification.</p> <p>Conclusions</p> <p>Our data showed that <it>PIK3CA </it>mutations were not common, but its amplification was very common in gastric cancer and may be a major mechanism in activating the PI3K/Akt pathway in gastric cancer. Importantly, Kaplan-Meier survival curves revealed that <it>PIK3CA </it>amplification was significantly positively associated with poor survival of gastric cancer patients. Collectively, the PI3K/Akt signaling pathway may be an effective therapeutic target in gastric cancer.</p

Leukadherin-1-Mediated Activation of CD11b Inhibits LPS-Induced Pro-inflammatory Response in Macrophages and Protects Mice Against Endotoxic Shock by Blocking LPS-TLR4 Interaction

Dysregulation of macrophage has been demonstrated to contribute to aberrant immune responses and inflammatory diseases. CD11b, expressed on macrophages, plays a critical role in regulating pathogen recognition, phagocytosis, and cell survival. In the present study, we explored the effect of leukadherin-1 (LA1), an agonist of CD11b, on regulating LPS-induced pro-inflammatory response in macrophages and endotoxic shock. Intriguingly, we found that LA1 could significantly reduce mortalities of mice and alleviated pathological injury of liver and lung in endotoxic shock. In vivo studies showed that LA1-induced activation of CD11b significantly inhibited the LPS-induced pro-inflammatory response in macrophages of mice. Moreover, LA1-induced activation of CD11b significantly inhibited LPS/IFN-γ-induced pro-inflammatory response in macrophages by inhibiting MAPKs and NF-κB signaling pathways in vitro. Furthermore, the mice injected with LA1-treated BMDMs showed fewer pathological lesions than those injected with vehicle-treated BMDMs in endotoxic shock. In addition, we found that activation of TLR4 by LPS could endocytose CD11b and activation of CD11b by LA1 could endocytose TLR4 in vitro and in vivo, subsequently blocking the binding of LPS with TLR4. Based on these findings, we concluded that LA1-induced activation of CD11b negatively regulates LPS-induced pro-inflammatory response in macrophages and subsequently protects mice from endotoxin shock by partially blocking LPS-TLR4 interaction. Our study provides a new insight into the role of CD11b in the pathogenesis of inflammatory diseases

Improved Ant Colony Algorithm for Global Optimal Trajectory Planning of UAV under Complex Environment

A novel type of Ant Colony Algorithm (ACA) for the globally optimal trajectory planning of Unmanned Aerial Vehicle (UAV) is proposed in this paper. The parallelism and positive feedback of ACA is feasible in UAV trajectory planning under complex environments, but the basic ACA model has the limitation of stagnation, and easy to fall into local optimum. Hybrid improvement strategies for the basic ACA model are proposed in this paper, and a type of trajectory smoothing scheme is also put forward. Simulation results show that the improved ACA is effective and can be used in the real-time trajectory planning of UAV. It has also been verified that the proposed method has better performance in convergence speed, solution variation, dynamic convergence behavior, and computational efficiency than the UAV trajectory planning method based on the basic ACA model under complex environments

More Constructions of 3-Weight Linear Codes

Linear codes with few weights have become an interesting research topic and important applications of cryptography and coding theory. In this paper, we apply some ternary near-bent and 2-plateaued functions or r-ary functions to construct more 3-weight linear codes, where r is a prime. Moreover, we determine the weight distributions of the resulted linear codes by means of some exponential sums

Aggregate Node Placements in Sensor Networks

In this paper we consider the design issue of sensor networks by placing a few powerful aggregate nodes into a dense sensor network such that the network lifetime is significantly prolonged when performing data gathering. Specifically, the problem is to place K aggregate nodes into a dense sensor network of n sensor nodes with K « n such that the lifetime of the resulting network is maximized, subject to the constraints that both the maximum transmission range of an aggregate node and the maximum transmission delay between an aggregate node and a sensor node covered by the aggregate node are met. Clearly, this is a joint optimization problem of aggregate node placement and the communication structure, which is NP-hard. We approach the problem by devising a fast and scalable heuristic algorithm. We also conduct experiments by simulation to evaluate its performance, and the experimental results show that the proposed algorithm outperforms a commonly equal distance placement schema significantly

A Content Distribution System based on Sparse Linear Network Coding

Abstract — With network coding, intermediate nodes between source and destination node(s) encode the incoming packets into new ones and forward them to their outgoing links. The original content is decoded at the destination node(s). Recent theoretical results show that network coding is beneficial for peer-to-peer(P2P) content distribution. To evaluate the benefit of network coding, we implement a P2P content distribution system based on the sparse linear network coding method. In our system, we use the Chord protocol to construct the system topology. We determine the proper encoding density so as to reach a high probability of generating independent encoded blocks, and to reduce the computational complexity of encoding packets at each peer. To improve the system performance, we use the encoding interval to reduce the probability of transmitting linear dependent packets and dependency test to avoid accepting linear dependent packets possibly from cyclic topology. Lastly, we carry out extensive experiments to show in terms of average downloading time at peers, total distribution time and system throughput, the system with network coding slightly outperforms a BitTorrent-like non-coding system using the local-rarest-first chunk selection policy. I

Experimental Demonstration and Simulation of Bandwidth-Limited Underwater Wireless Optical Communication with MLSE

Underwater wireless optical communication (UWOC) is able to provide large bandwidth, low latency, and high security. However, there still exist bandwidth limitations in UWOC systems, with a lack of effective compensation methods. In this paper, we systematically study the bandwidth limitation due to the transceiver and underwater channel through experiments and simulations, respectively. Experimental results show that by using the 7-tap maximum likelihood sequence estimation (MLSE) detection, the maximum bitrate of the simple rectangular shape on&ndash;off-keying (OOK) signaling is increased from 2.4 Gb/s to 4 Gb/s over 1 GHz transceiver bandwidth, compared to the conventional symbol-by-symbol detection. For the bandwidth limitation caused by the underwater channel, we simulate the temporal dispersion in the UWOC by adopting a Monte Carlo method with a Fournier&ndash;Forand phase function. With MLSE adopted at the receiver, the maximum available bitrate is improved from 0.4 to 0.8 Gb/s in 12 m of harbor water at the threshold of hard-decision forward-error-correction (HD-FEC, 3.8 &times; 10&minus;3). Moreover, when the bitrate for 0.4 Gb/s 12 m and 0.8 Gb/s 10 m OOK transmission remains unchanged, the power budget can be reduced from 33.8 dBm to 30 dBm and from 27.8 dBm to 23.6 dBm, respectively. The results of both experiments and simulations indicate that MLSE has great potential for improving the performance of bandwidth-limited communication systems