59 research outputs found
Modeling post-transcriptional regulation activity of small non-coding RNAs in Escherichia coli
Joint compression and deadline optimization for wireless federated learning
Federated edge learning (FEEL) is a popular distributed learning framework for privacy-preserving at the edge, in which densely distributed edge devices periodically exchange model-updates with the server to complete the global model training. Due to limited bandwidth and uncertain wireless environment, FEEL may impose heavy burden to the current communication system. In addition, under the common FEEL framework, the server needs to wait for the slowest device to complete the update uploading before starting the aggregation process, leading to the straggler issue that causes prolonged communication time. In this paper, we propose to accelerate FEEL from two aspects: i.e., 1) performing data compression on the edge devices and 2) setting a deadline on the edge server to exclude the straggler devices. However, undesired gradient compression errors and transmission outage are introduced by the aforementioned operations respectively, affecting the convergence of FEEL as well. In view of these practical issues, we formulate a training time minimization problem, with the compression ratio and deadline to be optimized. To this end, an asymptotically unbiased aggregation scheme is first proposed to ensure zero optimality gap after convergence, and the impact of compression error and transmission outage on the overall training time are quantified through convergence analysis. Then, the formulated problem is solved in an alternating manner, based on which, the novel joint compression and deadline optimization (JCDO) algorithm is derived. Numerical experiments for different use cases in FEEL including image classification and autonomous driving show that the proposed method is nearly 30X faster than the vanilla FedSGD algorithm, and outperforms the state-of-the-art schemes
Novel Modeling of Cancer Cell Signaling Pathways Enables Systematic Drug Repositioning for Distinct Breast Cancer Metastases
Hubs with Network Motifs Organize Modularity Dynamically in the Protein-Protein Interaction Network of Yeast
BACKGROUND: It has been recognized that modular organization pervades biological complexity. Based on network analysis, 'party hubs' and 'date hubs' were proposed to understand the basic principle of module organization of biomolecular networks. However, recent study on hubs has suggested that there is no clear evidence for coexistence of 'party hubs' and 'date hubs'. Thus, an open question has been raised as to whether or not 'party hubs' and 'date hubs' truly exist in yeast interactome. METHODOLOGY: In contrast to previous studies focusing on the partners of a hub or the individual proteins around the hub, our work aims to study the network motifs of a hub or interactions among individual proteins including the hub and its neighbors. Depending on the relationship between a hub's network motifs and protein complexes, we define two new types of hubs, 'motif party hubs' and 'motif date hubs', which have the same characteristics as the original 'party hubs' and 'date hubs' respectively. The network motifs of these two types of hubs display significantly different features in spatial distribution (or cellular localizations), co-expression in microarray data, controlling topological structure of network, and organizing modularity. CONCLUSION: By virtue of network motifs, we basically solved the open question about 'party hubs' and 'date hubs' which was raised by previous studies. Specifically, at the level of network motifs instead of individual proteins, we found two types of hubs, motif party hubs (mPHs) and motif date hubs (mDHs), whose network motifs display distinct characteristics on biological functions. In addition, in this paper we studied network motifs from a different viewpoint. That is, we show that a network motif should not be merely considered as an interaction pattern but be considered as an essential function unit in organizing modules of networks
The Key Application Technology of Desulfurized Gypsum in Dry-Mixed Mortar
In this paper, in view of the problem of low early and late strength of dry-mixed mortar prepared by cement-fly ash-slag powder composite cementing system, the ratio of mixing fly ash and slag powder to replace cement is 70%. To study the effect of desulfurization gypsum (FGD) on improving the activity of the system. The results show that adding desulfurized gypsum, which accounts for 6% to 8% of the total mass of the cementitious material, has no adverse effect on the workability and can significantly improve the compressive resistance of the slurry. Strength and tensile bonding strength, shrinkage rate is reduced by more than 10%, and the ability to resist carbonization is improved to make the mortar volume more stable
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