Research on Dynamic Evaluation Model of Slope Risk Based on Improved VW-UM

There are many accidents of slope failure due to rainfall at home and abroad, which have caused heavy casualties and property losses. Stability analysis and evaluation of slope have become a research hotspot. Aiming at the slope stability under different rainfall, this paper takes Yuebao Open-pit Mine slope as an example, has constructed a dynamic variable weight (VW) model of influencing factors on slope stability, and has analyzed the dynamic change and correlation of the slope indexes weights under different monthly maximum rainfall. On this basis, the dynamic evaluation model of slope stability has been established based on uncertainty measurement (UM), and the risk importance (RI) q which is proposed has quantitatively evaluated the risk degree of slope. The results show that under different monthly maximum rainfall the weight of each index is no longer a fixed value but a nonlinear and dynamic change law, and there is a strong correlation among the monthly maximum rainfall, internal friction angle, and cohesion. In addition, the q increases gradually with the increase of the monthly maximum rainfall, and the stability evaluation results are highly consistent with the HP1 slope, which have verified the reliability of the dynamic evaluation model. So, it can provide technical support for the safety production and management of open-pit slope and can also provide reference for related research

Techniques adopted in the rice azolla fish system with ridge culture

Meeting: National Rice Fish Farming Systems Symposium, 4-8 Oct. 1988, Wuxi, CNIn IDL-1614

hypersonicishapedaerodynamicconfigurations

Hypersonic vehicles, which flight at Mach numbers greater than 5, will serve as a more convenient and efficient transport tool than present subsonic airplanes for long-distance journeys in future. Typically, it only takes a couple of hours from Beijing to New York at hypersonic speed. Recent interest in these vehicles has grown intensively, and various types of innovative designs have been proposed and studied. Despite entering the age of hypersonic flight, there still exist many problems to resolve 1-4. How to design an advanced aerodynamic configuration is one of them 5

Effectiveness and safety of osimertinib in patients with metastatic EGFR T790M-positive NSCLC: An observational real-world study.

Osimertinib showed encouraging efficacy in patients with advanced EGFR T790M-positive NSCLC in previous randomized controlled trials. This real-world study aimed to evaluate the effectiveness and safety of osimertinib in a real-world setting. This observational study (NCT03133234) included 74 patients with metastatic EGFR T790M-positive NSCLC who progressed on prior EGFR TKI therapy and received osimertinib between May 2016 and April 2018 at the Kiang Wu Hospital in Macau. Response rate (RR) and other endpoints (progression-free survival [PFS], overall survival [OS], disease control rate [DCR], stable disease rate, and adverse events) were assessed. Survival data were estimated using the Kaplan-Meier method. All patients had stage IV lung adenocarcinoma and 25.6% had brain metastases; median age was 58 years (range 28-84 years) and 83.8% of patients had received at least three prior lines of treatment. The median duration of osimertinib treatment was 8 months (range, 1-25 months). RR and DCR were 67.5% (95% CI 56.9-78.1) and 79.8% (95% CI 70.7-88.9), respectively, while 12.1% had stable disease. The median PFS was 9.0 months (95% CI 6.7-11.2 months), and the median OS was 12.0 months (95% CI 8.8-15.1 months). Nausea (25.8%) and decreased appetite (20.2%) were the most common adverse events associated with osimertinib treatment. Even though most patients had at least three lines of prior treatment, real-world RR and PFS with osimertinib in this study were consistent with those from randomized controlled trials; no new safety signals were observed

Numerical investigation for subsonic performance of the high-pressure capturing wing configuration with wing dihedral

High-pressure capturing wing (HCW) aerodynamic configuration demonstrates favorable aerodynamic perfor-mance under hypersonic conditions, and its novel additional lifting wing (also known as HCW) has the potential to enhance lift characteristics under subsonic conditions. Therefore, this configuration presents a promising option for wide-speed-range vehicles. However, the stability characteristics of this novel configuration under subsonic conditions have not yet been investigated. In this paper, the effects of wing dihedral angles on the subsonic aerodynamic characteristics of a parametric conceptual HCW configuration with two lifting wings were investigated. Specifically, the design variables for this study were the dihedral angles of the upper HCW and the lower delta wing. To obtain the distributions of various aerodynamic parameters over the design space, a combination of the uniform experimental design method, computational fluid dynamics numerical simulation techniques, and kriging surrogate model algorithm was employed. The findings suggest that wing dihedral angles have a greater impact on the lift-drag ratio (L/D) at low angles of attack compared to high angles of attack. L/D can be enhanced by incorporating a positive dihedral angle in HCW, and as the delta wing's negative dihedral angle rises, L/D tends to increase earlier and decrease later at low angles of attack. Furthermore, for the lon-gitudinal, lateral, and directional stability characteristics of this configuration, the positive dihedral angles of the delta wing offer greater overall advantages than negative ones in improving them, and the positive dihedral angles of HCW yield more significant enhancements in stability compared to negative ones