Study on dynamic strength and liquefaction mechanism of silt soil in Castor earthquake prone areas under different consolidation ratios

Under the Castor earthquake, there is a risk of liquefaction instability of saturated tailings, and the evolution of dynamic pore pressure can indirectly reflect its instability process. Before applying dynamic loads, the static stress state of soil is one of the main factors affecting the development of soil dynamic strength and dynamic pore pressure, and there are significant differences in soil dynamic strength under different consolidation ratios. This paper conducted dynamic triaxial tests on saturated tailings silt with different consolidation ratios, and analyzed the dynamic strength variation and liquefaction mechanism of the samples using the discrete element method (PFC3D). The results showed that 1) as the Kc′ gradually increased, and there was a critical consolidation ratio Kc′ during the development of the dynamic strength of the sample. The specific value of Kc′ was related to the properties and stress state of saturated sand. The Kc′ in this research was about 1.9. When Kc < 1.9, dynamic strength was increased with the increase in Kc; when Kc > 1.9, dynamic strength was decreased with the Kc. 2) Under the impact of cyclic load, when samples were normally consolidated (Kc =1), the pore water pressure would tend to be equal to the confining pressure to cause soil liquefaction. In the case of eccentric consolidation (Kc > 1), the pore water pressure would be less than the confining pressure, thus, the soil liquefaction would not be induced, and the pore pressure value would decrease with the increase of consolidation ratio. This paper provides engineering guidance value for the study of dynamic strength and liquefaction mechanism of tailings sand and silt in Castor earthquake prone areas under different consolidation ratios

Potential molecular mechanisms of Erlongjiaonang action in idiopathic sudden hearing loss: A network pharmacology and molecular docking analyses

BackgroundIdiopathic sudden hearing loss (ISHL) is characterized by sudden unexplainable and unilateral hearing loss as a clinically emergent symptom. The use of the herb Erlongjiaonang (ELJN) in traditional Chinese medicine is known to effectively control and cure ISHL. This study explored the underlying molecular mechanisms using network pharmacology and molecular docking analyses.MethodThe Traditional Chinese Medicine System Pharmacological database and the Swiss Target Prediction database were searched for the identification of ELJN constituents and potential gene targets, respectively, while ISHL-related gene abnormality was assessed using the Online Mendelian Inheritance in Man and Gene Card databases. The interaction of ELJN gene targets with ISHL genes was obtained after these databases were cross-screened, and a drug component–intersecting target network was constructed, and the gene ontology (GO) terms, Kyoto Encyclopedia of Genes and Genomes, and protein–protein interaction networks were analyzed. Cytoscape software tools were used to map the active components–crossover target–signaling pathway network and screened targets were then validated by establishing molecular docking with the corresponding components.ResultErlongjiaonang contains 85 components and 250 corresponding gene targets, while ISHL has 714 disease-related targets, resulting in 66 cross-targets. The bioinformatical analyses revealed these 66 cross-targets, including isorhamnetin and formononetin on NOS3 expression, baicalein on AKT1 activity, and kaempferol and quercetin on NOS3 and AKT1 activity, as potential ELJN-induced anti-ISHL targets.ConclusionThis study uncovered potential ELJN gene targets and molecular signaling pathways in the control of ISHL, providing a molecular basis for further investigation of the anti-ISHL activity of ELJN

Research on the Macro-Mesoscopic Response Mechanism of Multisphere Approximated Heteromorphic Tailing Particles

AbstractThe shape of tailing particles is essential factors of their macroscopic mechanical properties. Scholars have studied the effects of controllable factors, such as loading method, confining pressure, and strain rate, on the strength of tailing sand. However, research on the tailing particle structure and shape through laboratory tests has proved to be difficult due to the uncertain and discrete tailing particle distribution. Thus, the macro-mesoscopic response of heteromorphic tailing particles is rarely investigated. In this paper, the macro-mesoscopic response of heteromorphic tailing particles is studied using multisphere approximation, and numerical simulation of triaxial tests on the particles is conducted. Nonlinear evolution patterns of porosity, internal friction angle, and cohesion of heteromorphic tailing particles with the variation of angularity were investigated using the flexible boundary program developed in this study, which revealed the intrinsic relationship between the mesostructure evolution mechanism and the macroscopic engineering characteristics of heteromorphic tailing particles. The research results showed that (1) changes in angularity led to tailing particle rearrangements and, in turn, porosity changes. With increased angularity and confining pressure, particle sphericity decreased, and the deviatoric and peak stress increased accordingly. In the meantime, the softening was more significant as the peak stress was exceeded, while the cohesive force generally increased. (2) With fixed particle shape and angularity, the internal friction angle decreased slightly as the effective confining pressure increased. (3) In the shearing process, the simulated contact force chain evolution of tailing particles with different shapes was similar. The disordered contact force chains gradually undergo directional connection, i.e., the increased confining pressure reduced the number of free tailing particles and increased the number of stressed particles. (4) The triaxial stress-strain and peak stress in rigid boundary simulations under different confining pressures were slightly lower than those in the flexible boundary simulations. However, the difference was insignificant, indicating the good feasibility and reasonability of rigid boundary simulations for the macroscopic mechanical behaviors in triaxial tests. The research results could offer more direct insights into the macro-mesoscopic response and mechanical mechanisms of nonspherical particles and provide references for the simulation of tailings at the microscopic levels

Experimental Study on Failure Model of Tailing Dam Overtopping under Heavy Rainfall

AbstractUnusual rainfall is the primary cause of the failure of the tailing dams, and overtopping is the most representative model of the tailing dam failure. The upstream tailing dam was selected as the research object to study the whole process of breach extension and the overtopping dam-failure mechanism under the full-scale rainfall condition. The results showed that the significant size grading phenomenon in the front, middle, and end of the tailing pond was obvious due to the flow separation effect, and its average particle diameter was D50. At different moments of rainfall, the height of the infiltration line at different positions of the dam body was different; at the rainfall of 3600 s, the height of the infiltration line lagged behind the height of the tailing pond, and this phenomenon from the tail of pond to the outside of the dam slope became more obvious. After the rainfall of 3600 s, the height of the infiltration line lagging behind the water level in the pond basically disappeared, and the rate of infiltration line rise kept pace with the rate of water level. The process of overtopping dam-failure experienced dam overtopping (gully erosion), formation of a multistepped small “scarp,” breach rapid expansion, formation of large “scarp,” and burst (fan-shaped formation). The width and depth of the breach showed a positive correlation, and the widening rate of the breach was 3 to 8 times of the deepening rate, especially in the middle of the dam break, widening behavior occupied the dominant factor. The shape of the dam body after failure was parabolic, and the dam body had obvious elevation changes. These results provide the theoretical guidance and engineering application value for improving the theory and early warning model of the upstream tailing dam

OP9-Lhx2 stromal cells facilitate derivation of hematopoietic progenitors both in vitro and in vivo

AbstractGenerating engraftable hematopoietic stem cells (HSCs) from pluripotent stem cells (PSCs) is an ideal approach for obtaining induced HSCs for cell therapy. However, the path from PSCs to robustly induced HSCs (iHSCs) in vitro remains elusive. We hypothesize that the modification of hematopoietic niche cells by transcription factors facilitates the derivation of induced HSCs from PSCs. The Lhx2 transcription factor is expressed in fetal liver stromal cells but not in fetal blood cells. Knocking out Lhx2 leads to a fetal hematopoietic defect in a cell non-autonomous role. In this study, we demonstrate that the ectopic expression of Lhx2 in OP9 cells (OP9-Lhx2) accelerates the hematopoietic differentiation of PSCs. OP9-Lhx2 significantly increased the yields of hematopoietic progenitor cells via co-culture with PSCs in vitro. Interestingly, the co-injection of OP9-Lhx2 and PSCs into immune deficient mice also increased the proportion of hematopoietic progenitors via the formation of teratomas. The transplantation of phenotypic HSCs from OP9-Lhx2 teratomas but not from the OP9 control supported a transient repopulating capability. The upregulation of Apln gene by Lhx2 is correlated to the hematopoietic commitment property of OP9-Lhx2. Furthermore, the enforced expression of Apln in OP9 cells significantly increased the hematopoietic differentiation of PSCs. These results indicate that OP9-Lhx2 is a good cell line for regeneration of hematopoietic progenitors both in vitro and in vivo

Dynamic response of full-length bonded anchor cable in rock slope

The research on the anchoring mechanism of slope anchor cable under earthquake action is not in-depth. Therefore, it has become an urgent problem in engineering practice to study the seismic characteristics of slope anchoring system and then realize the optimal design of slope anchoring. In this paper, the dynamic response of a rock slope strengthened with a full-length bonded anchor cable is studied by centrifuge model test. It is found that the internal structure of the rock slope has an important effect on the length of the bonded anchor cable. The structural surface will lead to an increase of the effective anchorage length, and the stress concentration of anchor cable will occur at the structural surface. This provides some references for the optimization of traditional anchorage theory

Numerical Simulation of Seepage Surface and Analysis of Phreatic Line Control from a Fine-Grained Tailings High Stacked Dam under Complicated Geography Conditions

Background: It is adverse for the safety of a tailings dam to use fine-grained tailings as the materials for a high tailings dam because of the low penetration coefficient, the slow consolidating velocity, and the bad physical mechanical property. Furthermore, with the influence of complicated geography conditions, the phreatic line will be increased enormously when encountering special conditions, which directly affect the safe operation of the tailings dam. Methods: In this study, based on the engineering, geological, and hydrogeological conditions and survey results of a tailings dam, a 210 m fine-grained tailings dam located in three gullies was selected and used to simulate the three-dimensional seepage field of a tailings dam under a steady saturated state by using the finite element software MIDAS GTS. The permeability coefficient was inverted, the seepage field of the project under different working conditions was simulated, and the position of the phreatic line was obtained. The controlled position of phreatic lines was determined by combining the seepage field with the stability requirements. Results: Back analysis could accurately reflect the actual permeability coefficient of each partition of tailings dams. Due to the multiple areas of seepage accumulation, large valley corners, and narrowing of the dam axis, the phreatic line of the shoulder region was elevated by 2~3 m compared to the surrounding area and was thereby the most critical region of the tailings dam seepage control. The stability requirements and minimum controlled position of the phreatic line requirements could be met when the controlled position of the phreatic line was 23 m. Conclusion: This study revealed the key areas and reasons why the tailings dam’s phreatic line is prone to be uplifted under complicated geography conditions. It was very critical to control the local phreatic line by adopting local horizontal seepage drainage measures or radiation wells in the key areas of the tailings dam to ensure the safety of the tailings dam. In addition to strengthening the daily monitoring of the key areas and the exfiltration facilities of the tailings dam, it is recommended to carry out determination tests of the permeability coefficient and particle size at regular intervals. The findings could provide countermeasures for seepage control

Anhydrous interfacial polymerization of sub-1 Å sieving polyamide membrane

Abstract Highly permeable polyamide (PA) membrane capable of precise ionic sieving can be utilized for many energy-efficient chemical separations. To fulfill this target, it is crucial to innovate membrane-forming process to induce a narrow pore-size distribution. Herein, we report an anhydrous interfacial polymerization (AIP) at a solid-liquid interface where the amine layer sublimated is in direct contact with the alkane containing acyl chlorides. In such a heterophase interface, water-caused side reactions are eliminated, and the amines in compact arrangement enable an intensive and orderly IP reaction, leading to a unique PA layer with an ionic sieving accuracy of 0.5 Å. The AIP-PA membrane demonstrates excellent separation selectivities of monovalent and divalent cations such as Mg2+/Li+ (78.3) and anions such as Cl-/SO4 2- (29.2) together with a high water flux up to 13.6 L m−2 h−1 bar−1. Our AIP strategy may provide inspirations for engineering high-precision PA membranes available in various advanced separations