Patient Recruitment Using Electronic Health Records Under Selection Bias: a Two-phase Sampling Framework

Electronic health records (EHRs) are increasingly recognized as a cost-effective resource for patient recruitment in clinical research. However, how to optimally select a cohort from millions of individuals to answer a scientific question of interest remains unclear. Consider a study to estimate the mean or mean difference of an expensive outcome. Inexpensive auxiliary covariates predictive of the outcome may often be available in patients' health records, presenting an opportunity to recruit patients selectively which may improve efficiency in downstream analyses. In this paper, we propose a two-phase sampling design that leverages available information on auxiliary covariates in EHR data. A key challenge in using EHR data for multi-phase sampling is the potential selection bias, because EHR data are not necessarily representative of the target population. Extending existing literature on two-phase sampling design, we derive an optimal two-phase sampling method that improves efficiency over random sampling while accounting for the potential selection bias in EHR data. We demonstrate the efficiency gain from our sampling design via simulation studies and an application to evaluating the prevalence of hypertension among US adults leveraging data from the Michigan Genomics Initiative, a longitudinal biorepository in Michigan Medicine

User independent Emotion Recognition with Residual Signal-Image Network

User independent emotion recognition with large scale physiological signals is a tough problem. There exist many advanced methods but they are conducted under relatively small datasets with dozens of subjects. Here, we propose Res-SIN, a novel end-to-end framework using Electrodermal Activity(EDA) signal images to classify human emotion. We first apply convex optimization-based EDA (cvxEDA) to decompose signals and mine the static and dynamic emotion changes. Then, we transform decomposed signals to images so that they can be effectively processed by CNN frameworks. The Res-SIN combines individual emotion features and external emotion benchmarks to accelerate convergence. We evaluate our approach on the PMEmo dataset, the currently largest emotional dataset containing music and EDA signals. To the best of author's knowledge, our method is the first attempt to classify large scale subject-independent emotion with 7962 pieces of EDA signals from 457 subjects. Experimental results demonstrate the reliability of our model and the binary classification accuracy of 73.65% and 73.43% on arousal and valence dimension can be used as a baseline

UADSN: Uncertainty-Aware Dual-Stream Network for Facial Nerve Segmentation

Facial nerve segmentation is crucial for preoperative path planning in cochlear implantation surgery. Recently, researchers have proposed some segmentation methods, such as atlas-based and deep learning-based methods. However, since the facial nerve is a tubular organ with a diameter of only 1.0-1.5mm, it is challenging to locate and segment the facial nerve in CT scans. In this work, we propose an uncertainty-aware dualstream network (UADSN). UADSN consists of a 2D segmentation stream and a 3D segmentation stream. Predictions from two streams are used to identify uncertain regions, and a consistency loss is employed to supervise the segmentation of these regions. In addition, we introduce channel squeeze & spatial excitation modules into the skip connections of U-shaped networks to extract meaningful spatial information. In order to consider topologypreservation, a clDice loss is introduced into the supervised loss function. Experimental results on the facial nerve dataset demonstrate the effectiveness of UADSN and our submodules

AstMatch: Adversarial Self-training Consistency Framework for Semi-Supervised Medical Image Segmentation

Semi-supervised learning (SSL) has shown considerable potential in medical image segmentation, primarily leveraging consistency regularization and pseudo-labeling. However, many SSL approaches only pay attention to low-level consistency and overlook the significance of pseudo-label reliability. Therefore, in this work, we propose an adversarial self-training consistency framework (AstMatch). Firstly, we design an adversarial consistency regularization (ACR) approach to enhance knowledge transfer and strengthen prediction consistency under varying perturbation intensities. Second, we apply a feature matching loss for adversarial training to incorporate high-level consistency regularization. Additionally, we present the pyramid channel attention (PCA) and efficient channel and spatial attention (ECSA) modules to improve the discriminator's performance. Finally, we propose an adaptive self-training (AST) approach to ensure the pseudo-labels' quality. The proposed AstMatch has been extensively evaluated with cutting-edge SSL methods on three public-available datasets. The experimental results under different labeled ratios indicate that AstMatch outperforms other existing methods, achieving new state-of-the-art performance. Our code will be available at https://github.com/GuanghaoZhu663/AstMatch