3 research outputs found
Adverse effects of vitamin E by induction of drug metabolism
- Author
- A Kontush
- AM Possolo
- ATBC prevention study group
- C Ioannides
- C Kiyose
- C Marras
- Collaborative group of the primary prevention project
- D Kluth
- D Steinberg
- DH Blatt
- DJ Mustacich
- DP Vivekananthan
- DQ Pham
- DR Nelson
- EB Rimm
- ER Miller 3rd
- FP Guengerich
- G Antoniadi
- G Bjelakovic
- G Bjelakovic
- GISSI Gruppo Italiano per lo Studio della Soprawivenza nell’Infarto miocardico
- H Hemila
- HOPE and HOPE-TOO trial investigators
- HOPE study investigators
- I Jialal
- I Jialal
- IM Lee
- JE Baggott
- JM Graat
- JM Lehmann
- JM Zingg
- JT Salonen
- K Kaneko
- K Klipstein-Grobusch
- K Krishnan
- KG Losonczy
- KJ DeZee
- KM Hayden
- L Hooper
- L Kritharides
- LC Quattrochi
- LH Kushi
- M Birringer
- M Birringer
- M Boaz
- M Lemcke-Norojärvi
- ME Wright
- MG Traber
- MG Traber
- MG Traber
- MJ Stampfer
- N Landes
- NC Ward
- NG Stephens
- P Knekt
- P Pfluger
- PG Shekelle
- R Brigelius-Flohé
- R Brigelius-Flohé
- R Brigelius-Flohé
- R Brigelius-Flohé
- R Marchioli
- Regina Brigelius-Flohé
- RM Salonen
- RS Bruno
- RS Bruno
- RS Eidelman
- RS Parker
- S Cholerton
- S Ikeda
- S Liu
- SA Kliewer
- SN Meydani
- SN Meydani
- T Carter
- T Morinobu
- TJ Sontag
- VW Bowry
- WJ Blot
- WS Lim
- Publication venue
- Springer-Verlag
- Publication date
- Field of study
Observational studies with healthy persons demonstrated an inverse association of vitamin E with the risk of coronary heart disease or cancer, the outcome of large-scale clinical trials conducted to prove a benefit of vitamin E in the recurrence and/or progression of such disease, however, was disappointing. Vitamin E did not provide benefits to patients with cardiovascular diseases, cancer, diabetes or hypertension. Even harmful events and worsening of pre-existing diseases were reported, which are hard to explain. Since vitamin E is metabolized along the same routes as xenobiotics and induces drug-metabolizing enzymes in rodents, it is hypothesized that a supplementation with high dosages of vitamin E may also lead to an induction of the drug-metabolizing system in patients that depend on drug therapy. Compromising essential therapy might therefore outweigh any benefit of vitamin E in patients. It is recommended to work out at which threshold the drug-metabolizing system can be induced in humans before new trials with high dosages of vitamin E are started
Drugs in Development
- Author
- (Second International Study of Infarct Survival) Collaborative Group.
- A. Colombo
- A. Schömig
- A.A. Bos van den
- A.B. Kelly
- A.M. Telford
- A.R. Giles
- A.V. Kaplan
- A.W. Clowes
- A.W. Lensing
- Antiplatelet Trialists Collaboration.
- Antiplatelet Trialists’ Collaboration
- Antiplatelet Trialists’ Collaboration.
- B. Casu
- B. Hoet
- B. Rath
- B.C. Berk
- B.H. Chong
- B.J. Meyer
- B.S. Coller
- B.S. Coller
- B.S. Coller
- B.S. Coller
- B.S. Coller
- C. Cerletti
- C. Dunwiddie
- C. Gachet
- C. Gachet
- C. Kettner
- C. Patrono
- C. Patrono
- C. Picard-Fraire
- C.B. Granger
- C.D. Lee
- C.M. Gasperetti
- C.P. Cannon
- C.P. Cannon
- C.P. Cannon
- C.R. Narins
- C.S. Rihal
- C.T. Esmon
- C.T. Esmon
- CW White
- D. Collen
- D. Phillips
- D.A. Lane
- D.F. Johnson
- D.H. Farrell
- D.H. Farrell
- D.J. Ellis
- D.J. Fitzgerald
- D.J. Fitzgerald
- D.J. Kereiakes
- D.J. King
- D.M. Keeling
- D.P. Bono De
- E. Falk
- E. Minar
- E.G. Vairel
- E.J. Hornby
- E.J. Topol
- E.J. Topol
- E.J. Topol
- E.M. Antman
- E.M. Antman
- E.M. Bevers
- E.M. Ohman
- E.M. Ohman
- E.P. Gurfinkel
- E.R. Bates
- E.S. Barnarhan
- F. Balsano
- F. Clerck De
- F. Violi
- F.A. Ofosu
- F.A. Ofosu
- F.A. Ofosu
- F.J. Neumann
- F.V. Aguirre
- F.W. Dunn
- F.W.A. Verheugt
- G. Defreyn
- G. Gabliani
- G. Minno Di
- G.A. FitzGerald
- G.A. FitzGerald
- G.A. Marguerie
- G.C. Flaker
- G.G. Neri Serneri
- G.I. Fiddler
- G.J. Roth
- G.P. Tuszynski
- G.P. Vlasuk
- G.R. Buchanan
- G.R. Sitko
- G.S. Reeder
- G.V. Sharma
- Gruppo Italiano per lo Studio della Soprawivenza nell’Infarto Miocardico.
- H. Deckmyn
- H. Garabedian
- H. J. Heparin
- H. Lee
- H. Tabata
- H. Wolf
- H.D. Lewis Jr
- H.K. Gold
- H.K. Gold
- H.K. Gold
- H.N. Magnani
- I.A. Reilly
- I.K. Jang
- I.K. Jang
- ISIS-3 (Third International Study of Infarct Survival) Collaborative Group.
- J Vermylen
- J. Arnout
- J. Conard
- J. Fareed
- J. Fuchs
- J. Hauptmann
- J. Hirsh
- J. Hirsh
- J. Hsia
- J. Jesty
- J. Lefkovits
- J. Lefkovits
- J. O’Brien
- J. O’Brien
- J. Rosing
- J. Vermylen
- J. Weitz
- J.A. Ambrose
- J.A. Ambrose
- J.A. Ambrose
- J.A. Bittl
- J.A. Cairns
- J.A. Oates
- J.A. Szalony
- J.B. Knudsen
- J.D. Marmur
- J.D. Ogilby
- J.E. Manson
- J.E. Tcheng
- J.E. Tcheng
- J.E. Tcheng
- J.E. Willard
- J.H. Chesebro
- J.H. Ip
- J.I. Weitz
- J.J. Ferguson
- J.J. Thebault
- J.M. Harlan
- J.M. Herbert
- J.M. Maraganore
- J.M. Maraganore
- J.M. Maraganore
- J.N. Wilcox
- J.P. Miletich
- J.R. Vane
- J.R. Vane
- J.R. Wilentz
- J.S. Rosenberg
- J.T. Willerson
- J.T. Willerson
- J.W. Weisel
- J.W.D. Fenton
- JJ Popma
- K. Ono
- K.G. Dougherty
- K.J. Winters
- K.L. Neuhaus
- K.L. Neuhaus
- K.M. Kent
- K.W. Mahaffey
- L. Badimon
- L. Fiore
- L. Harker
- L. Janzon
- L. Schwartz
- L. Waxman
- L.A. Harker
- L.D. Fiore
- L.F. Satler
- L.S. Simon
- L.S. Simon
- L.V. Lee
- M. Bertrand
- M. Cattaneo
- M. Chevigne
- M. Gent
- M. Hamberg
- M. Talbot
- M. Verstraete
- M.A. Wood De
- M.A. Wood De
- M.C. Morice
- M.D. Pierschbacher
- M.E. Bertrand
- M.E. Rothlin
- M.J. Davies
- M.J. Mellott
- M.J. Underwood
- M.K. Ito
- M.L. Messmore
- M.L. Simoons
- M.N. Levine
- M.P. Savage
- M.R. Mooney
- M.S. Dennis
- M.W. Liu
- N. Pfluger
- N.J. Fouw de
- N.J. Lembo
- N.P. Lips
- N.S. Kleiman
- N.S. Nicholson
- P. Barragan
- P. Golino
- P. Gresele
- P. Gresele
- P. Gresele
- P. Hall
- P. Prandoni
- P. Serruys
- P. Theroux
- P. Theroux
- P. Theroux
- P. Theroux
- P. Zoldhelyi
- P.A. Kyrie
- P.B. Tracy
- P.J. Hogg
- P.L. Barker
- P.N. Walsh
- P.R. Eisenberg
- P.T. Vaitkus
- P.W. Serruys
- P.W. Serruys
- R. Feliste
- R. Hynes
- R. Limet
- R. Peto
- R. Ross
- R. Ross
- R.A. Harrington
- R.A. Raschke
- R.B. Haynes
- R.D. Hull
- R.D. Hull
- R.D. Rosenberg
- R.D. Rosenberg
- R.H. Aster
- R.J. Anders
- R.J. Gould
- R.L. Nachman
- R.M. Hardisty
- R.M. Knabb
- R.M. Lidon
- R.M. Scarborough
- R.M. Scarborough
- R.O. Hynes
- R.P. Harvey
- R.R. Arora
- R.R. Vassallo Jr
- R.S. Schwartz
- R.T. Brittain
- R.W. Hacker
- S. Béguin
- S. Ellis
- S. Okamoto
- S.A. Mousa
- S.G. Ellis
- S.I. Rapaport
- S.L. Adams
- S.L. Adams
- S.P. Schulman
- S.R. Coughlin
- S.R. Stone
- S.W. Tam
- Steering Committee of the Physicians’ Health Study Research Group.
- T. Yasuda
- T.A. Mabin
- T.E. Warkentin
- T.E. Warkentin
- T.F. McGarry Jr
- T.H. Muller
- T.K. Vu
- T.L. Ortel
- T.W. Barrowcliffe
- The EPIC Investigators.
- The Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) IIa Investigators.
- The GUSTO Angiographic Investigators.
- The GUSTO investigators.
- The International Study Group.
- The Ridrogel Versus Apirin Patency Trial (RAPT)
- The RISC Group.
- V. Bartele
- V. Fuster
- V. Fuster
- V. Schachinger
- W. Ruf
- W.C. Roberts
- W.K. Hass
- W.L. Barry
- Y. Cadroy
- Y. Nemerson
- Y. Uchida
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1997
- Field of study
Coronary Artery Disease and Endothelial Function
- Author
- A Benigni
- A Bloodsworth
- A Blum
- A Dendorfer
- A Gaglione
- A Haunstetter
- A Hjalmarson
- A Huang
- A Lerman
- A Lerman
- A Lerman
- A Maseri
- A Mulsch
- A Mügge
- A Nitenberg
- A Prasad
- A Prasad
- A Scanu
- A Tawakol
- A Virdis
- AA Quyyumi
- AA Quyyumi
- AA Quyyumi
- AA Quyyumi
- AC Carr
- AC Carr
- AC Yeung
- AD Hingorani
- AG Bowie
- AG Pockley
- AJ Camm
- AM Zeiher
- AM Zeiher
- AM Zeiher
- AM Zeiher
- AM Zeiher
- AM Zeiher
- AM Zeiher
- AM Zeiher
- AM Zeiher
- AM Zeiher
- AM Zeiher
- AM Zeiher
- B Hornig
- B Lindahl
- B Pitt
- B Schieffer
- BG Brown
- BL Langille
- BL Lopez
- BW Hochleitner
- C Bokhoven
- C Cardillo
- C Cardillo
- C Cardillo
- C Cardillo
- C Cardillo
- C Patterson
- C Seiler
- CA DeSouza
- CA Farquharson
- CA Schneider
- CB Treasure
- CB Treasure
- CD Furberg
- CD Garlichs
- CJ McKenna
- CJ Packard
- CJ Smith
- CM Webb
- D Behr-Roussel
- D Hoffman
- D Schultz
- DA Cox
- DE Newby
- DE Newby
- DE Vaughan
- DG Harrison
- DG Harrison
- DH Silber
- DH Walter
- DJ Grainger
- DJ Rader
- DM Gilligan
- DP Hajjar
- DS Celermajer
- DS Celermajer
- DS Celermajer
- DS Celermajer
- E Bassenge
- E Bassenge
- E Falk
- E Gurfinkel
- E Marban
- E Napoleone
- EG Nabel
- EH Awtry
- EJ Topol
- EL Schiffrin
- ER Levin
- F Diet
- F Haverkate
- F Perticone
- F Tronc
- FK Timimi
- FM Sacks
- FM Sacks
- FW Sellke
- G Liuzzo
- G Lupattelli
- G O’Driscoll
- G O’Driscoll
- G Pasterkamp
- G Schuler
- G Utermann
- GAF Gerald
- GB Mancini
- GB Mancini
- GG Schwartz
- GH Dahlén
- GK Goode
- GM Pieper
- GN Levine
- GN Levine
- GR Upchurch Jr
- Gruppo Italiano per lo Studio della Soprawivenza nell’infarto Miocardico
- GS Huggins
- H Cai
- H Ruetten
- H Shimokawa
- H Soejima
- H Vink
- H Watanabe
- HH Ting
- HH Ting
- HJ Oskarsson
- HO Steinberg
- HW Wilmink
- I Antony
- I Fleming
- I Ikonomidis
- I Philip
- I Yokoyama
- IJ Kullo
- ISIS-4 Collaborative Group
- IT Meredith
- J Bauersachs
- J Bauersachs
- J Bauersachs
- J Danesh
- J Danesh
- J Dorn
- J Frielingsdorf
- J Galle
- J Goodfellow
- J Kahler
- J Lambert
- J Niebauer
- J Pernow
- J Shepherd
- J Vinten-Johansen
- JA Berliner
- JA Panza
- JA Panza
- JA Panza
- JA Suwaidi
- JA Vita
- JA Vita
- JA Vita
- JB Laurensen
- JB Muhlestein
- JC Chambers
- JC Chambers
- JD Morrow
- JE Brush
- JE Manson
- JH Traverse
- JK Williams
- JL Mehta
- JM Mostaza
- JN Wilcox
- JP Cooke
- JP Cooke
- JP Halcox
- JP Noon
- JR Cockcroft
- JR Horowitz
- JR Vane
- JW Jukema
- K Asai
- K Bhagat
- K Egashira
- K Egashira
- K Egashira
- K Hisamoto
- K Kugiyama
- K Kugiyama
- K Kugiyama
- K Raza
- K Yogo
- KA Hajjar
- KH Benzuly
- KK Griendling
- KK Griendling
- KK Koh
- KK Koh
- KL Gould
- KL McNeill
- KM Channon
- KS Russell
- KS Woo
- KS Woo
- KS Woo
- L Ghiadoni
- L Kuo
- L Linder
- L Poston
- L Vergnani
- LB Nielsen
- LI Sinoway
- LM Title
- LV Ravichandran
- M Barton
- M Burnier
- M Evans
- M Hernandez-Presa
- M Mayr
- M Moroi
- M Mutin
- M Pahor
- M Rath
- M Reilly
- M Torzewski
- M Vasa
- MA Broeders
- MB Britten
- MB Britten
- MB Britten
- MC Verhaar
- MD Enderle
- ME Haberland
- MF Bellamy
- MJ Mullen
- MJ Mullen
- ML Honing
- ML Kukin
- ML Marcus
- MN Diaz
- MR Adams
- MR Malinow
- MS Wolin
- MT Johnstone
- MW Radomski
- N Gokce
- N Inoue
- N Inoue
- N Rosenthal
- N Sattar
- NA Flavahan
- O Belton
- O Tamai
- OT Raitakari
- OT Raitakari
- P Bogaty
- P Clarkson
- P Clarkson
- P Cremer
- P Dupouy
- P Forte
- P Libby
- P Pagliaro
- P Poredos
- P Schoenhagen
- P Vallance
- P Verhoef
- PA Kaufmann
- PH Dagassen
- PH Stone
- PJ Barnes
- PL Huang
- PL Ludmer
- PM Abuja
- PM Ridker
- PM Ridker
- PM Ridker
- PM Ridker
- PR Casino
- PR Casino
- PR Casino
- Q Xu
- R Bergholm
- R Busse
- R Butler
- R Campisi
- R Erbel
- R Hambrecht
- R Heller
- R MacAlpin
- R Popp
- R Ross
- RA Cohen
- RA Nishimura
- RA Skyrme-Jones
- RA Skyrme-Jones
- RD Rudic
- RF Furchgott
- RH Boger
- RJ Esper
- RLJ Minor
- RM Goetz
- RM Lawn
- RM Wever
- RMJ Palmer
- RO Cannon III
- RP Brandes
- RP Brandes
- RR Azar
- RR Wenzel
- RS Rosenson
- RW Alexander
- RW Alexander
- S Breuer
- S Dimmeier
- S Dimmeler
- S Dimmeler
- S Fichtischerer
- S Fichtischerer
- S Fichtischerer
- S Glagov
- S Gupta
- S Hulley
- S Husain
- S John
- S Kinlay
- S Kinlay
- S Kurz
- S Laurent
- S Makimattila
- S Moncada
- S Moncada
- S Taddei
- S Taddei
- S Taddei
- S Taddei
- S Vehkavaara
- S Yla-Herttuala
- S Yusuf
- S Yusuf
- SB Williams
- Scandinavian Simvastatin Survival Study Group
- SE Epstein
- SE Reis
- SJ Duffy
- SJ Duffy
- SJ Duffy
- SR Lentz
- T Heitzer
- T Heitzer
- T Heitzer
- T Heitzer
- T Heitzer
- T Münzel
- T Münzel
- T Münzel
- T Münzel
- T Münzel
- T Neunteufl
- T Neunteufl
- TC Andrews
- TF Lüscher
- TF Lüscher
- TF Lüscher
- TF Lüscher
- TF Zioncheck
- TI Goodfriend
- TJ Anderson
- TJ Anderson
- TJ Anderson
- TJ Anderson
- TJ Guzik
- TJ Guzik
- TV Lewis
- U Landmesser
- U Laufs
- U Solzbach
- V Fuster
- V Guetta
- V Pasceri
- V Schächinger
- V Schächinger
- V Schächinger
- V Schächinger
- V Schächinger
- V Schächinger
- V Schächinger
- V Schächinger
- V Schächinger
- VW Armstrong
- WB Strawn
- WG Haynes
- WG Haynes
- WK Lagrand
- X Zhang
- Y Hirooka
- Y Matsuda
- Y Nishikawa
- Y Ohara
- Y Ohara
- Y Tsurumi
- Y Yoon
- Z Mallat
- Z Yang
- ZS Kyriakides
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2002
- Field of study