Gospodarski učinak zabrane državne pomoći rumunjskoj čeličnoj industriji

The adjustment of the Romanian steel industry restructuring programmes to the requirements of the EU and the implementation of such programmes has supported the development and growth of Romanian steel companies.The total amount of State aid allowed in Romania has been of € 1,2 billion and was mainly awarded for financial restructuring and to a smaller extent for exemption from VAT and corporation tax. The EC has constantly monitored the Romanian steel industry and the way in which State aid has been granted by the Romanian government. As a consequence of the restructuring process– whit entry into force the EU Association Agreement was enforced – several obsolescent plants have been shut down because of physical and moral wear and tear, and the total number steelworkers has decreased significantly.Prilagodba programa preustroja rumunjske čelične industrije zahtjevima Europske unije i provedba tih programa pripomogle su razvitku i rastu rumunjskih poduzeća djelatnih u čeličnoj industriji. Državna pomoć odobrena u Rumunjskoj ukupno je iznosila 1,2 milijarde US dolara i uglavnom se dodjeljivala za financijski preustroj, a u manjoj mjeri za izuzeće od PDV-a i poreza na dobit. EK je stalno pratila rumunjsku čeličnu industriju i način na koji je rumunjska vlada dodjeljivala državna pomoć. Kao posljedak procesa preustroja – stupanjem na snagu Sporazuma o pridruživanju EU – zatvoreno je nekoliko zastarjelih tvornica zbog istrošenosti te je broj radnika u čeličnoj industriji značajno smanjen

Преклинический атеросклероз: эндотелиальная дисфункция, комплекс интима-медиа, сосудистая жесткость

Preclinical atherosclerosis is an acute problem of contemporary medicine with significant effects on cardiovascular morbidity and mortality. Targeting strategy to tackle atherosclerotic disease at incipient clinical stages is undertaken to achieve a significant reduction in major cardiovascular events and reliance on an early assessment of serum markers of endothelial dysfunction and other noninvasive indicators of asymptomatic atherosclerotic arterial disease, such as the intimae-media thickness and arterial stiffness.Преклинический атеросклероз является острой проблемой современной медицины и обладает значительным влиянием на сердечно- сосудистую заболеваемость и смертность. Ориентация стратегии борьбы с атеросклеротической болезнью на преклинических стадиях нацелена на достижение значительного снижения основных сердечно-сосудистых осложнений и основана на ранней оценке сывороточных маркеров эндотелиальной дисфункции и на других неинвазивных показателях бессимптомного атеросклеротического поражения артерий, таких как толщина комплекса интима-медиа и жесткость сосудистых стенок

The oxidative stress in blood hypothermic and normothermic cardioplegia

Department of Cardiac Surgery, Republican Hospital, Institute of Cardiology, Chisinau, the Republic of MoldovaBackground: The oxidative stress is a potent tool of myocardial injury having a special significance during open-heart surgery. Obtaining of hypothermic cardioplegia is based on the decrease of myocard’s metabolic efficiency which results in the increase of its resistance to ischemia. Material and methods: This article is aimed at the evaluation of main indices belonging to oxidative stress in venous coronary sinus blood in 60 patients exposed to valvulopathy correction using hypothermic and normothermic cardioplegia. The patients were divided into 2 groups, depending on cardioplegia: group 1 comprised 30 patients that were subjected to blood hypothermic cardioplagia (t < 33ºC); group 2 also consisted of 30 patients, subjected to blood normothermic cardioplegia (t ≥ 33ºC). The groups were homogenous considering clinical and functional indices of the heart, detected with the patients before the surgical intervention. Results: The oxidative stress is found to be activated in open-heart surgery evidence proved by serum lipid hydroperoxides (LH) and malonic dialdehyde (MD) significant increase across 110 min of ischemia and at 2-3 min of reperfusion till 55.7-58.9%. This enhancement is associated with antioxidant system failure due to a significant quantitative reducing of the main antioxidant compounds at 55 and 110 min of ischemia, gluthation-peroxidase, gluthation-reductase, superoxide-dismutase (SOD), catalase (CAT) and total antioxidant activity (TAA) the most marked decline being characteristic to SOD and CAT (41.85-46.20%). However TAA and CAT have elevated in reperfusion start by 14.4 and 32.6%. Conclusions: The normothermic cardioplegia was appreciated as a more favorable condition concerning myocardial antioxidant protection ensuring because it provided a less rise of LH and MD as well as a less depletion of explored antioxidant factors

Enhancing the Sustainability of the Aviation Industry: Airlines’ Commitment to “Green” Practices

The aviation industry represents an important polluter, being responsible for increasing environmental impacts on global scale. Aiming to approach the adoption of suitable policies in the aviation industry towards the achievement of the national and international sustainability goals, the present research tackles airlines’ commitment to aviation-related environmental issues, as well as their willingness to adopt sustainable aviation fuel (i.e., bio jet fuel) and sustainable development strategies, focusing on those companies operating flights in the Karol Wojtyła Airport (Bari, Italy). The paper adopts the χ2 test and the logistic regression to investigate three different hypotheses related to airlines’ headquarters, carriers’ typology (i.e., low-cost or not, flag carriers or not) and years of service. Results outline that traditional airlines, either flag carriers or not, as well as South and North American companies, are more likely to be aware of aviation environmental consequences, publishing environmental reports and offering to passengers the chance to participate to climate change reduction (e.g., through online carbon offset programs or more expensive ticket to produce bio jet fuels). In addition, airlines transiting in Karol Wojtyła Airport show a small willingness to share information through environmental reports and are scarcely intentioned to make use of bio jet fuels, confirming that low-cost companies are still less attentive towards aviation environmental issues. The present research contributes to the empirical studies on sustainable aviation and carriers’ commitment to environmental strategies, highlighting the need to enhance carbon offsets programs and digital technologies as the online compensation of CO2 emissions

Attacking the V:On the resiliency of adaptive-horizon MPC

Inspired by the emerging problem of CPS security, we introduce the concept of controller-attacker games. A controller-attacker game is a two-player stochastic game, where the two players, a controller and an attacker, have antagonistic objectives. A controller-attacker game is formulated in terms of a Markov Decision Process (MDP), with the controller and the attacker jointly determining the MDP’s transition probabilities. We also introduce the class of controller-attacker games we call V-formation games, where the goal of the controller is to maneuver the plant (a simple model of flocking dynamics) into a V-formation, and the goal of the attacker is to prevent the controller from doing so. Controllers in V-formation games utilize a new formulation of model-predictive control we have developed called Adaptive-Horizon MPC (AMPC), giving them extraordinary power: we prove that under certain controllability conditions, an AMPC controller can attain V-formation with probability 1. We evaluate AMPC’s performance on V-formation games using statistical model checking. Our experiments demonstrate that (a) as we increase the power of the attacker, the AMPC controller adapts by suitably increasing its horizon, and thus demonstrates resiliency to a variety of attacks; and (b) an intelligent attacker can significantly outperform its naive counterpart

Пренатальная диагностика мышечной дистрофии и спинальной мышечной атрофии за последние 4 года и эффективности существующей методологии пренатальной диагностики в Республике Молдова

IMSP Institutul Mamei şi Copilului Centrul de Sănătate a Reproducerii şi Genetică MedicalăIntroduction. The severity of hereditary diseases is already well known throughout the world. The monitoring and prevention of hereditary diseases are the current tasks of medical genetics and health. Prenatal diagnosis (PD) is one of the methods proposed to prevent the birth of children with congenital malformations incorrigible, monogenic and chromosomal pathologies. Muscular dystrophy Duchenne / Becker and spinal muscular atrophies are neuromuscular hereditary X-linked and respectively autosomal recessive disorders and that are frequently encountered in Moldova and can be detected through prenatal diagnosis. Materials and methods. The research was held in the scientific department of the Centre for Reproductive Health and Medical Genetics, Laboratory of Human Molecular Genetics. After medico-genetic consultation pregnant women who are at risk of having a pregnancy affected by a hereditary disease, namely Duchenne and Becker muscular dystrophy (DMD/B) and spinal muscular atrophy (SMA) undergo prenatal diagnosis (PD), which Moldova is achieved by methods such as multiplex PCR, PCR / RFLP, the primer sets specific and polymorphic sites. Purpose. The purpose of the work is to present data of prenatal diagnosis of neuromuscular disorders with high frequency in Moldova during the last four years. Results. In total were performed 14 prenatal diagnoses: 9 - DMD/B and 5 for SMA during 2011-2014. Making the prenatal diagnosis of DMD/B and SMA has allowed the direct analysis of deletions or RFLP test and were detected 4 affected fetuses, 3 of them were with DMD / B and 1 with SMA. Have been analyzed the strategies for prenatal diagnosis of these diseases in different countries and their methods. Conclusions. Prenatal diagnosis is an important strategy and an effective way to prevent the birth of children with hereditary monogenic diseases in families at risk. This strategy applies to all populations, but with different methodologies. The methods of modern molecular genetic prenatal diagnosis raise the efficiency and precision to 98%. The efficiency of prenatal diagnosis in Moldova is 71,4%. Analyzing different diagnostic methods used in the world was proposed as the method which will be better implemented in Moldova.Введение. Тяжесть наследственных заболеваний хорошо известна во всем мире. Лечебно-диагностические стратегии и методы анализируются и затем ставятся акценты в их развитии. Ключевой особенностью является неравномерного их распределение. Мониторинг и предотвращение наследственных заболеваний являются текущими задачами медицинской генетики. Пренатальная диагностика (ПД) является главным методом предотвращения рождения детей с моногенной и хромосомной патологии. Миодистрофия Дюшенна / Беккера и спинальная мышечная атрофия являются наследственными нервно-мышечными болезнями, которые часто встречаются в Р. Молдова и проведение ПД этих заболеваний возможно в нашей стране. Материалы и методы. Исследования проводились в научном отделе Центра Репродуктивного Здоровья и Медицинской Генетики, в лаборатории молекулярной генетики человека. После медико-генетического консультирования беременных женщин с высоким риском наследственных болезней, а именно МДД/Б и СМА проводится ПД. Мультиплексная ПЦР и анализ сцепления (ПЦР- ПДРФ) используются в Республике Молдова. Цель. Анализ результатов пренатальной диагностики, проведенных за последние четыре года в Лаборатории молекулярной генетики человека и оценка эффективности ПД в РМ. Результаты. В течение 2011-2014г. было сделано 14 пренатальных диагностических тестов: 9ПД на МДД/Б и 5 на СМА. Используя прямой поиск протяженных делеций методом МПЦР и анализ сцепления (ПЦР- ПДРФ) позволило выявить 4 плода с наследственными болезнями: 3 плода с МДД/Б и одного c СМА. Проанализировано стратегии и методы ПД, использующиеся в разных странах в настоящее время и проведен анализ эффективности применения существующих методов ПД в РМ. Эффективность составляет 71,4%. Выводы. Пренатальная диагностика является важной стратегией и эффективным способом предотвратить рождение детей с наследственными моногенными заболеваниями. Стратегия ПД применяется во многих популяциях, но с использованием различных методов. Применение молекулярно-генетических методов при современной ПД повышает эффективность и точность до 98% по данным литературы, но эффективность ПД в РМ составляет 71,4%. Предложены современные молекулярно-генетические методы ПД, которые повысят эффективность и точность ПД

Синдром хронической сердечной недостаточности вторичной Тетраде Фалло: клинические и диагностические аспекты на основе одного случая

Department of Pediatrics, Nicolae Testemitanu State Medical and Pharmaceutical University, Congresul III al Medicilor de Familie din Republica Moldova, 17–18 mai, 2012, Chişinău, Republica Moldova, Conferinţa Naţională „Maladii bronhoobstructive la copii”, consacrată profesorului universitar, doctor habilitat Victor Gheţeul, 27 aprilie, Chişinău, Republica MoldovaThe authors present a clinical case of a 17 year old boy, which in his clinical and paraclinical data highlighted the following diagnostic: Congenital heart failure; Tetralogy of Fallot; AV Block gr. III; Mitral valve insufficiency gr. IV; Tricuspid valve insufficiency gr. IV; Heart failure NYHA functional class gr. III-IV. The case focuses on complications that may occur in late cardio surgeries and the development of AV block gr. III disorders. If complications arose during the evolution of the disease, there would have been performed multiple pacemaker reimplantations. The article insists on the way how cardiovascular complications start as much as on the importance of prompt medical supervision to ensure the patient’s quality of life.В данной статье описан клинический случай ребёнка в возрасте 17 лет, у которого по клинико-инструментальным данным был установлен клинический диагноз – врожденный порок сердца, Tетрада Фалло, aтриовентрикулярная блокада III-ей степени. Имплантация исскуственного кардиостимулятора ритма сердца (1998, 2002, 2007). Недостаточность митрального клапана IV-ой степени. Недостаточность трикуспидального клапана IV-ой степени. НК IV NYHA

Поражение сердца при саркоидозе

Department of Cardiac Emergency and Rhythm Disorders, Institute of CardiologyCardiac sarcoidosis is a rare but potentially fatal condition that can mimic more common conditions. Recent advances in imaging technology that allow easier detection of cardiac involvement confirm that minimally symptomatic or asymptomatic cardiac involvement is far more prevalent than previously thought. Often the first manifestation of cardiac sarcoidosic is sudden death or a cardiac arrest. Because of the potential life-threatening complications and potential benefit of treatment, all patients diagnosed with sarcoidosis should be screened for cardiac involvement. We studied a 57 year old female patient with acute onset of this illness manifested by recurrent ventricular arrhythmias and progressive heart failure. We confirmed cardiac involvement by magnetic resonance imaging after discovering characteristic mediastinal lymphadenopathy at the high-resolution computed tomography. Corticosteroid treatment and the implantable cardioverter-defibrillator improved the long-term clinical condition. At the end of the 8th month of supervision the patient retained her asymptomatic clinical condition.Поражение сердца при саркоидозе редкое заболевание, но возможность смертельного заболевания могут имитировать частые заболевания. После первых проявлений поражения сердца при саркоидозе возникает внезапная смерть или остановка сердца. Так как это может быть опасным для жизни осложнением и потенциальным эффектом лечения, у всех пациентов с диагнозом саркоидоз может быть поражено и сердце. Возникновение клинических проявлений при поражении сердца в саркоидозе сопровождается неблагоприятным прогнозом. Представлен клинический случай пациентки, 57 лет, без сердечно-сосудистой патологии в анамнезе, с острым началом саркоидоза, проявленным тяжелым поражением сердца, с выраженной дисфункцией левого желудочка и с желудочковой тахиаритмией. Применение кортикостероидной терапии и имплантация дефибриллятора-кардиовертера улучшили состояние пациентки на длительный период времени

Electron-fluctuation interaction in a non-Fermi superconductor

We studied the influence of the amplitude fluctuations of a non-Fermi superconductor on the energy spectrum of the 2D Anderson non-Fermi system. The classical fluctuations give a temperature dependence in the pseudogap induced in the fermionic excitations.Comment: revtex fil