Autologous antibodies to human bladder cancer

The autologous serologic reactivity of 13 patients with bladder cancer was evaluated using cell lines derived from each individual's own tumor as targets. Protein A and immune adherence assays were employed to determine antibody binding to the tumor targets at varying passage numbers. Autologous reactivity was found in 6 of the 13 cell lines tested. However, the titer was usually low regardless of the passage number. Seven autologous serum/cell line combinations were tested using both low and high passage cells as targets. In six of these combinations, the degree of antibody binding was similar with both low and high passage target cells. The incidence of autologous reactivity in the 12 patients with urothelial tumors was 50%.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46855/1/262_2004_Article_BF00199940.pd

Stellar Lyman-alpha Emission Lines in the Hubble Space Telescope Archive: Intrinsic Line Fluxes and Absorption from the Heliosphere and Astrospheres

We search the Hubble Space Telescope (HST) archive for previously unanalyzed observations of stellar H I Lyman-alpha emission lines, our primary purpose being to look for new detections of Lyman-alpha absorption from the outer heliosphere, and to also search for analogous absorption from the astrospheres surrounding the observed stars. The astrospheric absorption is of particular interest because it can be used to study solar-like stellar winds that are otherwise undetectable. We find and analyze 33 HST Lyman-alpha spectra in the archive. All the spectra were taken with the E140M grating of the Space Telescope Imaging Spectrograph (STIS) instrument on board HST. The HST/STIS spectra yield 4 new detections of heliospheric absorption (70 Oph, Xi Boo, 61 Vir, and HD 165185) and 7 new detections of astrospheric absorption (EV Lac, 70 Oph, Xi Boo, 61 Vir, Delta Eri, HD 128987, and DK UMa), doubling the previous number of heliospheric and astrospheric detections. When combined with previous results, 10 of 17 lines of sight within 10 pc yield detections of astrospheric absorption. This high detection fraction implies that most of the ISM within 10 pc must be at least partially neutral, since the presence of H I within the ISM surrounding the observed star is necessary for an astrospheric detection. In contrast, the detection percentage is only 9.7% (3 out of 31) for stars beyond 10 pc. Our Lyman-alpha analyses provide measurements of ISM H I and D I column densities for all 33 lines of sight, and we discuss some implications of these results. Finally, we measure chromospheric Lyman-alpha fluxes from the observed stars. We use these fluxes to determine how Lyman-alpha flux correlates with coronal X-ray and chromospheric Mg II emission, and we also study how Lyman-alpha emission depends on stellar rotation.Comment: 56 pages, 15 figures; AASTEX v5.0 plus EPSF extensions in mkfig.sty; accepted by ApJ

Biocarbon ureterostomy device for urinary diversion Multicenter clinical trial

The bioCarbon ureterostomy device is a stomal prosthesis for upper tract urinary diversion that has had preliminary successes in animal and human trials in Europe and Peru. Implantation of a pure carbon stomal prosthesis offers the potential advantages of high biocompatibility, lack of encrustation, and elimination of stomal stenosis which is frequently associated with cutaneous ureterostomy. Nine bioCarbon ureterostomy devices were implanted from August, 1984 through July, 1985. Although successful implantation was achieved in 2 patients, the complication rate was high. The bioCarbon ureterostomy device has potential as an alternative form of urinary diversion. However, significant problems need to be remedied before it can be recommended for routine clinical application.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/28101/1/0000548.pd

BioTIME: A database of biodiversity time series for the Anthropocene.

MotivationThe BioTIME database contains raw data on species identities and abundances in ecological assemblages through time. These data enable users to calculate temporal trends in biodiversity within and amongst assemblages using a broad range of metrics. BioTIME is being developed as a community-led open-source database of biodiversity time series. Our goal is to accelerate and facilitate quantitative analysis of temporal patterns of biodiversity in the Anthropocene.Main types of variables includedThe database contains 8,777,413 species abundance records, from assemblages consistently sampled for a minimum of 2 years, which need not necessarily be consecutive. In addition, the database contains metadata relating to sampling methodology and contextual information about each record.Spatial location and grainBioTIME is a global database of 547,161 unique sampling locations spanning the marine, freshwater and terrestrial realms. Grain size varies across datasets from 0.0000000158 km2 (158 cm2) to 100 km2 (1,000,000,000,000 cm2).Time period and grainBioTIME records span from 1874 to 2016. The minimal temporal grain across all datasets in BioTIME is a year.Major taxa and level of measurementBioTIME includes data from 44,440 species across the plant and animal kingdoms, ranging from plants, plankton and terrestrial invertebrates to small and large vertebrates.Software format.csv and .SQL

The Stock Market Evaluation of IPO-Firm Takeovers

We conduct an event study to assess the stock market evaluation of public takeover announcements. Unlike the majority of previous research, we specifically focus on acquisitions targeted at newly public IPO-firms and show that the stock market positively evaluates these M&As as R&D. However, bidders' abnormal announcement returns are significantly lower for takeovers directed at targets with critical intangible assets and innovative capabilities inalienably bound to their initial owners than for those that have internally accumulated respective resources and capabilities. We explain these findings with the acquirer's post-acquisition dependence on continued access to the IPO-firm founders' target-specific human capital. Our results contribute to literature in that they show that the stock market perceives these potential impediments to successful exploitation of acquired strategic resources and thus identify a potential cause for heretofore mostly inconsistent evidence on bidder abnormal returns in corporate takeovers found in previous research

Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility

Systemic lupus erythematosus (SLE), a complex polygenic autoimmune disease, is associated with increased complement activation. Variants of genes encoding complement regulator factor H (CFH) and five CFH-related proteins (CFHR1-CFHR5) within the chromosome 1q32 locus linked to SLE, have been associated with multiple human diseases and may contribute to dysregulated complement activation predisposing to SLE. We assessed 60 SNPs covering the CFH-CFHRs region for association with SLE in 15,864 case-control subjects derived from four ethnic groups. Significant allelic associations with SLE were detected in European Americans (EA) and African Americans (AA), which could be attributed to an intronic CFH SNP (rs6677604, in intron 11, Pmeta = 6.6×10-8, OR = 1.18) and an intergenic SNP between CFHR1 and CFHR4 (rs16840639, Pmeta = 2.9×10-7, OR = 1.17) rather than to previously identified disease-associated CFH exonic SNPs, including I62V, Y402H, A474A, and D936E. In addition, allelic association of rs6677604 with SLE was subsequently confirmed in Asians (AS). Haplotype analysis revealed that the underlying causal variant, tagged by rs6677604 and rs16840639, was localized to a ~146 kb block extending from intron 9 of CFH to downstream of CFHR1. Within this block, the deletion of CFHR3 and CFHR1 (CFHR3-1Δ), a likely causal variant measured using multiplex ligation-dependent probe amplification, was tagged by rs6677604 in EA and AS and rs16840639 in AA, respectively. Deduced from genotypic associations of tag SNPs in EA, AA, and AS, homozygous deletion of CFHR3-1Δ (Pmeta = 3.2×10-7, OR = 1.47) conferred a higher risk of SLE than heterozygous deletion (Pmeta = 3.5×10-4, OR = 1.14). These results suggested that the CFHR3-1Δ deletion within the SLE-associated block, but not the previously described exonic SNPs of CFH, might contribute to the development of SLE in EA, AA, and AS, providing new insights into the role of complement regulators in the pathogenesis of SLE