Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study

Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Therefore, we aimed to generate a novel measure of disease progression and to identify genetic markers associated with this progression measure

Search for long-lived, weakly interacting particles that decay to displaced hadronic jets in proton-proton collisions at root s=8 TeV with the ATLAS detector

A search for the decay of neutral, weakly interacting, long-lived particles using data collected by the ATLAS detector at the LHC is presented. This analysis uses the full data set recorded in 2012: 20.3 fb(-1) of proton-proton collision data at root s = 8 TeV. The search employs techniques for reconstructing decay vertices of long-lived particles decaying to jets in the inner tracking detector and muon spectrometer. Signal events require at least two reconstructed vertices. No significant excess of events over the expected background is found, and limits as a function of proper lifetime are reported for the decay of the Higgs boson and other scalar bosons to long-lived particles and for Hidden Valley Z' and Stealth SUSY benchmark models. The first search results for displaced decays in Z' and Stealth SUSY models are presented. The upper bounds of the excluded proper lifetimes are the most stringent to date

Search for squarks and gluinos in final states with jets and missing transverse momentum at root s=13 TeV with the ATLAS detector

A search for squarks and gluinos in final states containing hadronic jets, missing transverse momentum but no electrons or muons is presented. The data were recorded in 2015 by the ATLAS experiment in root s = 13 TeV proton-proton collisions at the Large Hadron Collider. No excess above the Standard Model background expectation was observed in 3.2 fb(-1) of analyzed data. Results are interpreted within simplified models that assume R-parity is conserved and the neutralino is the lightest supersymmetric particle. An exclusion limit at the 95 % confidence level on the mass of the gluino is set at 1.51 TeV for a simplified model incorporating only a gluino octet and the lightest neutralino, assuming the lightest neutralino is massless. For a simplified model involving the strong production of mass-degenerate first- and second-generation squarks, squark masses below 1.03 TeV are excluded for a massless lightest neutralino. These limits substantially extend the region of supersymmetric parameter space excluded by previous measurements with the ATLAS detector

Search for flavour-changing neutral current top-quark decays to q Z in pp collision data collected with the ATLAS detector at root s=8 TeV

A search for the flavour-changing neutral-current decay is presented. Data collected by the ATLAS detector during 2012 from proton-proton collisions at the Large Hadron Collider at a centre-of-mass energy of root s = 8 TeV, corresponding to an integrated luminosity of 20.3 fb(-1), are analysed. Top-quark pair-production events with one top quark decaying through the t -> qZ (q = u,c) channel and the other through the dominant Standard Model mode t -> bW are considered as signal. Only the decays of the Z boson to charged leptons and leptonic W boson decays are used. No evidence for a signal is found and an observed (expected) upper limit on the t -> qZ branching ratio of 7 x 10(-4) (8 x 10(-4)) is set at the 95 % confidence level