Relevance of blood tumor markers in inpatients with significant involuntary weight loss and elevated levels of inflammation biomarkers

International audiencePurpose To assess the diagnostic performance of a panel of standard tumor markers (TMs) in patients hospitalized with significant involuntary weight loss (IWL) and elevated levels of inflammation biomarkers, and a combination of the TM panel and the finding of the computed tomography (CT) scan. Methods We conducted a retrospective study in the internal medicine department at Amiens-Picardie University Medical Center (Amiens, France) between January 1st, 2015, and November 1st, 2021. The inclusion criteria were age 18 or over, significant IWL (≥ 5 kg over 6 months), elevated inflammation biomarkers (e.g. C-reactive protein), and assay data on two or more standard TMs (carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 19 − 9, CA 15 − 3, CA 125, neuron-specific enolase (NSE), alpha-fetoprotein (AFP), calcitonin, and prostate-specific antigen (PSA)). The result of each TM assay was interpreted qualitatively (as positive or negative), according to our central laboratory’s usual thresholds. Results Cancer was diagnosed in 50 (37.0%) of the 135 patients included. Positivity for one or more TMs had a positive predictive value (PPV) of 0.55 [0.43–0.66], and a negative predictive value (NPV) of 0.84 [0.75–0.93] for cancer diagnosis. When combined with the presence of suspicious CT findings (e.g. a mass, enlarged lymph nodes and/or effusion), positivity for one or more TMs had a PPV of 0.92 [0.08–0.30]. In the absence of suspicious CT findings, a fully negative TM panel had an NPV of 0.96 [0.89-1.00]. Conclusion A negative TM panel argues against the presence of a cancer, especially in the absence of suspicious CT findings

Entre terre et mer, le site précolombien de Folle Anse (Grand-Bourg, Marie Galante). Enjeux scientifiques et méthodologie d’approche

International audienceThe pre-Columbian site of Folle Anse (Grand-Bourg) on the island of Marie-Galante was discovered and excavated in the 1960s by R.P. Barbotin. Further research was carried out by R. Chenorkian at the end of the last century. This work uncovered traces of pre-Columbian occupation spanning some 1,500 years. One of the original features of the site is the presence of two stratigraphically distinct occupations linked to the Early Ceramic period. The first has been assigned to the Huecan saladoid sub-series, the second to the early phase of the Cedrosan saladoid sub-series. In addition, the deposit is located on a beach that has undergone significant retreat in recent decades. In March 2024, we resumed investigations at the site with a coordinated systematic coring and test pits campaign at sea and on land. The objectives of this work, carried out by a multidisciplinary team, were multiple. The first was to investigate the nature of cultural diversity in the West Indies during the Early Ceramic period. Secondly, a global geoarchaeological approach to the site (both on land and at sea) was to explore long-term sedimentary dynamics and, above all, the possibility of the underwater conservation of terrigenous sedimentary layers linked to the Amerindian occupation of the site. Finally, the aim was to develop a global view of the evolution of sea level and coastline in the area of the site. The present communication, a few days after the end of the first campaign carried out on the site, will focus on the issues at stake in the project, the original methodological approach developed in the field and the initial results obtained.Le site précolombien de Folle Anse (Grand-Bourg) dans l’île de Marie-Galante a été découvert et fouillé dès les années 1960 par le R.P. Barbotin. D’autres recherches y ont été ensuite menées par R. Chenorkian à la fin du siècle dernier. Ces travaux ont permis de mettre au jour les traces d’une occupation précolombienne s’étendant de façon discontinue sur environ 1500 ans. L’une des originalités du site est de présenter deux occupations stratigraphiquement distinctes rattachées au Céramique Ancien. La première a été rattachée à la sous-série saladoïde huecane, la seconde à la phase ancienne de la sous-série saladoïde cedrosane. Par ailleurs, le gisement est localisé sur une plage ayant connu un important recul au cours des dernières décennies. En mars 2024, nous avons repris les investigations sur le site au travers d’une opération coordonnée en mer et à terre de carottage et de sondage. Les objectifs de ces travaux menés par une équipe pluridisciplinaire étaient multiples. Il s’agissait dans un premier temps d’interroger la nature de la diversité culturelle dans les Antilles au cours du Céramique Ancien. Dans un second temps, une approche géoarchéologique globale du gisement (tant à terre qu’en mer) devait explorer les dynamiques sédimentaires dans le temps long et surtout la possibilité de la conservation sous-marine de couches sédimentaires terrigènes en lien avec l’occupation amérindienne du gisement. Enfin, il s’agissait de développer une réflexion globale de l’évolution du niveau marin et du trait de côte dans le secteur du site. La présente communication, quelques jours après la fin de la première campagne menée sur le site, se concentrera sur les enjeux problématiques du projet, l’approche méthodologique originale développée sur le terrain et les premiers résultats obtenus

Entre terre et mer, le site précolombien de Folle Anse (Grand-Bourg, Marie Galante). Enjeux scientifiques et méthodologie d’approche

International audienceThe pre-Columbian site of Folle Anse (Grand-Bourg) on the island of Marie-Galante was discovered and excavated in the 1960s by R.P. Barbotin. Further research was carried out by R. Chenorkian at the end of the last century. This work uncovered traces of pre-Columbian occupation spanning some 1,500 years. One of the original features of the site is the presence of two stratigraphically distinct occupations linked to the Early Ceramic period. The first has been assigned to the Huecan saladoid sub-series, the second to the early phase of the Cedrosan saladoid sub-series. In addition, the deposit is located on a beach that has undergone significant retreat in recent decades. In March 2024, we resumed investigations at the site with a coordinated systematic coring and test pits campaign at sea and on land. The objectives of this work, carried out by a multidisciplinary team, were multiple. The first was to investigate the nature of cultural diversity in the West Indies during the Early Ceramic period. Secondly, a global geoarchaeological approach to the site (both on land and at sea) was to explore long-term sedimentary dynamics and, above all, the possibility of the underwater conservation of terrigenous sedimentary layers linked to the Amerindian occupation of the site. Finally, the aim was to develop a global view of the evolution of sea level and coastline in the area of the site. The present communication, a few days after the end of the first campaign carried out on the site, will focus on the issues at stake in the project, the original methodological approach developed in the field and the initial results obtained.Le site précolombien de Folle Anse (Grand-Bourg) dans l’île de Marie-Galante a été découvert et fouillé dès les années 1960 par le R.P. Barbotin. D’autres recherches y ont été ensuite menées par R. Chenorkian à la fin du siècle dernier. Ces travaux ont permis de mettre au jour les traces d’une occupation précolombienne s’étendant de façon discontinue sur environ 1500 ans. L’une des originalités du site est de présenter deux occupations stratigraphiquement distinctes rattachées au Céramique Ancien. La première a été rattachée à la sous-série saladoïde huecane, la seconde à la phase ancienne de la sous-série saladoïde cedrosane. Par ailleurs, le gisement est localisé sur une plage ayant connu un important recul au cours des dernières décennies. En mars 2024, nous avons repris les investigations sur le site au travers d’une opération coordonnée en mer et à terre de carottage et de sondage. Les objectifs de ces travaux menés par une équipe pluridisciplinaire étaient multiples. Il s’agissait dans un premier temps d’interroger la nature de la diversité culturelle dans les Antilles au cours du Céramique Ancien. Dans un second temps, une approche géoarchéologique globale du gisement (tant à terre qu’en mer) devait explorer les dynamiques sédimentaires dans le temps long et surtout la possibilité de la conservation sous-marine de couches sédimentaires terrigènes en lien avec l’occupation amérindienne du gisement. Enfin, il s’agissait de développer une réflexion globale de l’évolution du niveau marin et du trait de côte dans le secteur du site. La présente communication, quelques jours après la fin de la première campagne menée sur le site, se concentrera sur les enjeux problématiques du projet, l’approche méthodologique originale développée sur le terrain et les premiers résultats obtenus

Climate change and archaeological heritage: beyond the logic of urgency.The pre-Columbian site of Folle Anse (Grand-Bourg, Marie Galante)

International audienceThe pre-Columbian site of Folle Anse (Grand-Bourg) on the island of Marie-Galante was discovered and excavated in the 1960s by R.P. Barbotin. Further research was carried out by M. Grandguillote and then by R. Chenorkian at the end of the last century. This work revealed traces of pre-Columbian occupation dating back some 2000 years. One of the original features of the site is the presence of two stratigraphically distinct occupations related to the Early Ceramic Period. The first has been assigned to the Huecan Saladoid sub-series, the second to the early phase of the Cedrosan Saladoid sub-series. In addition, the deposit is located on a beach that has undergone significant retreat in recent decades.In March 2024, we resumed investigations at the site with a coordinated coring and drilling campaign at sea and on land. The first goal was to investigate the nature of cultural diversity in the West Indies during the Early Ceramic Period. Second, a global geoarchaeological approach to the site (both on land and at sea) was designed to explore the long-term sedimentary dynamics and, in particular, the possibility of underwater preservation of terrigenous sedimentary layers associated with the Amerindian occupation of the site. Finally, it aimed to develop a global approach to the evolution of sea levels and coastlines in the area of the site. In this way, we see this operation as a form of response, free from the logic of urgency, to the programmed disappearance of a large part of the pre-Columbian archaeological heritage of the West Indies in the coming decades

Additional file 1 of Relevance of blood tumor markers in inpatients with significant involuntary weight loss and elevated levels of inflammation biomarkers

Supplementary Material

A novel pathogenic variant in MRAP2 in an obese patient with successful outcome of bariatric surgery

International audienceAbstract Mutations in genes encoding proteins located in the leptin/melanocortin pathway have been identified in the rare cases of genetic obesities. Heterozygous variants of MRAP2, encoding a G coupled-protein receptor accessory protein implicated in energy control notably via the melanocortin-4 receptor, have been recently identified. A 24-year-old patient with early-onset severe obesity (body mass index [BMI]: 64 kg/m2) associated with hypertension, respiratory complications, nonalcoholic fatty liver disease, and type 2 diabetes was referred to our department. Sleeve gastrectomy was successful. A new heterozygous variant in MRAP2 (NM_138409.4: c.154G>C/p.G52R) variant was identified in the patient DNA. Functional assessment confirmed that this new variant was pathogenic. We report a new pathogenic loss-of-function mutation in MRAP2 in a patient suffering from a severe multicomplicated obesity. This confirms the metabolic phenotype in patients with this monogenic form of obesity. Longer follow-up will be necessary. Our finding will allow a personalized medicine

Temps et espaces de l’occupation céramique ancienne de la Martinique

International audienc

Temps et espaces de l’occupation céramique ancienne de la Martinique

International audienc

Temps et espaces de l’occupation céramique ancienne de la Martinique

International audienc

Temps et espaces de l’occupation céramique ancienne de la Martinique

International audienc