Role of membrane lipids in the regulation of erythrocytic oxygen-transport function in cardiovascular diseases

The composition and condition of membrane lipids, the morphology of erythrocytes, and hemoglobin distribution were explored with the help of laser interference microscopy (LIM) and Raman spectroscopy. It is shown that patients with cardiovascular diseases (CVD) have significant changes in the composition of their phospholipids and the fatty acids of membrane lipids. Furthermore, the microviscosity of the membranes and morphology of the erythrocytes are altered causing disordered oxygen transport by hemoglobin. Basic therapy carried out with the use of antiaggregants, statins, antianginals, beta-blockers, and calcium antagonists does not help to recover themorphofunctional properties of erythrocytes. Based on the results the authors assume that, for the relief of the ischemic crisis and further therapeutic treatment, it is necessary to include, in addition to cardiovascular disease medicines, medication that increases the ability of erythrocytes’ hemoglobin to transport oxygen to the tissues. We assume that the use of LIM and Raman spectroscopy is advisable for early diagnosis of changes in the structure and functional state of erythrocytes when cardiovascular diseases develop

One or many project offices in educational organization of tertiary education: advantages and disadvantages

The article is devoted to the creating and management expediency of several project offices in an educational organization of tertiary education (hereinafter – OTE). The topic relevance is due to the growing number and types of ongoing projects that require proper organization and management and, consequently, governance of project management offices. The article presents the features of educational projects and the role of the project management office in the OTE system. The main types of project management offices at universities and their functions and tasks are described. Common elements of successful project management offices from around the world are highlighted based on a global study conducted by the Project Management Institute (PMI) together with PricewaterhouseCoopers (PwC) in 2021. The advantages and disadvantages of creating a single system of several project offices of different orientation and a single project management office at the university are discussed. Based on the information from the scientific literature and the conducted research, the authors conclude that in order to use all the advantages of the project office in full, it is necessary to create one project office in OTE. However, the authors also claim the need for further research to assess the feasibility of the practical implementation of their proposed solution

2-aminoaethanesulfonic acid compounds possess protective property in reperfusion-induced heart jnjury

The study aim was to explore pharmacological effects of 2-aminoaethansulfonic acid compounds in reperfusion-induced heart injury. The study was performed on rats and dogs of both sexes, isolated rats’ hearts. Two compounds of 2-aminoethanesulfonic acid, magnesium-containing (LBK-527) and phenylacetamide-containing (LKhT-317) were investigate

Regional Aspects of Nosocomial Infection As a Medical and Social Problem

Prevention of nosocomial infection (NI) is an important medical and socioeconomic problem. And though certain organizational and practical measures are implemented in Russia every year to reduce NIs, the problem is still relevant from medical and social points of view. The risk of infection are both for patients and medical workers. In Russia, the minimum economic damage caused by NIs is 2.5–5 billion rubles annually. According to the Office of the Federal Service for Supervision of Consumer Rights Protection and Human Welfare in the Republic of Mordovia, the total incidence of NI in the region is at a low level. The incidence rate was 0.01 per 1000 patients in hospitals. The dynamics of the last five years demonstrates a decrease in hospital-acquired infections. In the dynamics of the last five years, incidence rates of purulent-septic infections of newborns and postpartum women, postoperative purulent-septic complications and post-injection complications had an unstable downward trend. Thus, purulent-septic infections of newborns and postpartum women and postoperative infections are dominated in the structure of nosocomial infections. Analysis of dynamics of morbidity in recent years in the Republic of Mordovia suggests that the measures taken to prevent NI are quite effective and are manifested with consistently low rates

Magnetospheric convection from Cluster EDI measurements compared with the ground-based ionospheric convection model IZMEM

Cluster/EDI electron drift observations above the Northern and Southern polar cap areas for more than seven and a half years (2001–2008) have been used to derive a statistical model of the high-latitude electric potential distribution for summer conditions. Based on potential pattern for different orientations of the interplanetary magnetic field (IMF) in the GSM y-z-plane, basic convection pattern (BCP) were derived, that represent the main characteristics of the electric potential distribution in dependence on the IMF. The BCPs comprise the IMF-independent potential distribution as well as patterns, which describe the dependence on positive and negative IMF<I>B<sub>z</sub></I> and IMF<I>B<sub>y</sub></I> variations. The full set of BCPs allows to describe the spatial and temporal variation of the high-latitude electric potential (ionospheric convection) for any solar wind IMF condition near the Earth's magnetopause within reasonable ranges. The comparison of the Cluster/EDI model with the IZMEM ionospheric convection model, which was derived from ground-based magnetometer observations, shows a good agreement of the basic patterns and its variation with the IMF. According to the statistical models, there is a two-cell antisunward convection within the polar cap for northward IMF<I>B<sub>z</sub></I>+≤2 nT, while for increasing northward IMF<I>B<sub>z</sub></I>+ there appears a region of sunward convection within the high-latitude daytime sector, which assumes the form of two additional cells with sunward convection between them for IMF<I>B<sub>z</sub></I>+≈4–5 nT. This results in a four-cell convection pattern of the high-latitude convection. In dependence of the ±IMF<I>B<sub>y</sub></I> contribution during sufficiently strong northward IMF<I>B<sub>z</sub></I> conditions, a transformation to three-cell convection patterns takes place

Concerning effective and safe dosages of vitamin D3: mega-analysis of clinically effective studies as a basis for actual evidence

The negative effects of hypovitaminosis D3 and vitamin D3 deficiency in 80% of Russians make eliminating vitamin D deficiency an issue of state concern. Hundreds of effective clinical studies showed realistic opportunities of vitamin D3 to help patients with disorders of carbohydrate and lipid metabolism, high levels of nonspecific inflammation, tuberculosis, and women with a higher risk of complications and pregnancy losses. Vitamin D3 supplements are essential for the prevention and treatment of a wide range of “bone” and “extraosseous” diseases. One of the most important aspects of the clinical uses of vitamin D3 is the dosage and dosage regimen of the vitamin. This paper presents the results of a “mega-analysis” of 3965 clinical studies of vitamin D3 in terms of the effectiveness of different dosages in achieving different clinical outcomes. It was shown that dosages of 2000 IU/day and 4000 IU/day correspond to the peak values of the effectiveness index, regardless of the diagnoses studied (mega-analysis of 420 randomized trials). Some effectiveness in the treatment of rickets, gestational diabetes, calcium metabolism disorders, disorders of bone density and structure, diseases of the musculoskeletal system and connective tissue can be achieved using weekly dosages of 50,000 IU/week (mega-analysis of 196 studies). It has been shown that dosages of 100,000-1,000,000 IU, intended for a single dose once a month, are almost always found only among studies with a negative result (mega-analysis of 368 studies)