Projekt Herbizide: Die Problematik von Wirkungsschwellenwerten in Pharmakologie und Toxikologie

Copy held by FIZ Karlsruhe; available from UB/TIB Hannover / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Kombinationswirkungen von Schadstoffen. Toxizitaet binaerer Kombinationen von Pestiziden und Tensiden im Algenbiotest. T. 1

Combined effects of 137 binary mixtures of 14 pesticides and 5 surfactants have been studied using an algal biotest. Concentration response relationships were statistically estimated and the suitability of different models and concepts for the assessment of combined effects in aquatic biotests was evaluated. Depending on the model there were differences concerning the assessment of combined effects at different effect levels, the sensitivity to detect synergism or antagonism, and the biometrical requirements. The observed mixture toxicities were in almost all cases stronger than what could be expected from the most potent component alone. On the basis of the concept of concentration addition, mixture toxicities were generally well predictable. Independent of the mode of action of the components of the various mixtures, the differences between predicted and observed mixture toxicities were less than factor 1.6 in 80% of the evaluated cases. (orig.)SIGLEAvailable from TIB Hannover: RN 8908(95-065,1) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Umwelt, Naturschutz und Reaktorsicherheit, Bonn (Germany)DEGerman

Kombinationswirkungen von Schadstoffen. Toxizitaet binaerer Kombinationen von Pestiziden und Tensiden im Algenbiotest. T. 2 Materialienband

Combined effects of 137 binary mixtures 14 pesticides and 5 surfactants have been studied using an algal biotest. Concentration response relationships were statistically estimated and the suitability of different models and concepts for the assessment of combined effects in aquatic biotests was evaluated. Depending on the model there were differences concerning the assessment of combined effects at different effect levels, the sensitivity to detect synergism or antagonism, and the biometrical requirements. The observed mixture toxicities were in almost all cases stronger than what could be expected from the most potent component alone. On the basis of the concept of concentration addition, mixture toxicities were generally well predictable. Independent of the mode of action of the components of the various mixtures, the differences between predicted and observed mixture toxicities were less than 1.6 in 80% of the evaluated cases. (orig.)SIGLEAvailable from TIB Hannover: RN 8908(95-065,2) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Umwelt, Naturschutz und Reaktorsicherheit, Bonn (Germany)DEGerman

Vorhersagbarkeit und Beurteilung der aquatischen Toxizitaet von Stoffgemischen. Multiple Kombinationen von unaehnlich wirkenden Substanzen in niedrigen Konzentrationen

SIGLEAvailable from TIB Hannover: RR 6252(1998,25) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Bildung, Wissenschaft, Forschung und Technologie, Bonn (Germany)DEGerman