Primjena frakcijske plinske analize za određivanje sadržaja oksidnih i dušičnih faza u ALNICO legurama

Fractional gas analysis procedure for estimating the contents of oxide and nitride inclusions in Alnico alloys produced from wastes of production is developed. The effect of the temperature and time of melt holding before pouring on the content of impurity oxide and nitride inclusions is considered. The content of SiO2 inclusions in Alnico mainly depends on the holding time before pouring and decreases with increasing holding time, whereas the content of Al2O3 inclusions decreases with increasing both temperature and time of holding. The content of TiN inclusions decreases with increasing holding time. As the holding temperature increases, the content of nitride inclusions decreases only with increasing holding time.Razrađena je metoda frakcijske plinske analize za vrednovanje oksidnih i dušičnih uključaka u ALNICO legurama, dobijenih iz gospodarskih otpada. Posmatran je utjecaj temperature i vremena zadržavanja kupke prije lijevanja. Sadržaj uključaka SiO2 uglavnom ovisi od vremena zadrške prije lijevanja i snižava se povećanjem tog vremena, istodobno se sadržaj uključaka Al2O3 smanjuje s povećavanjem i temperature i vremena zadrške. Sadržaj uključaka TiN smanjuje se povećavanjem vremena zadrške. S povećanjem temperature sadržaj dušičnih uključaka smanjuje se samo pri povećanju vremena zadrške prije lijevanja

Применение интеллектуальной системы криминального анализа в реальном времени (ricas) для аналитического сопровождения оперативно-розыскной деятельности и досудебного расследования

Uzlov, D.Y., Strukov, V.M., Grigorovich, A.B., Petrusenko, A.I. and Doskalenko, S.N. (2015), “Use of Real-time Intellectual criminal analytics system (RICAS) for analytical support of operative and search activities and pre-trial investigation” [“Primenenie intellektual’noj sistemy kriminal’nogo analiza v real’nom vremeni (RICAS) dlja analiticheskogo soprovozhdenija operativno-rozysknoj dejatel’nosti i dosudebnogo rassledovanija”], Pravo i Bezpeka, No. 2, pp. 132–139.Применение интеллектуальной системы криминального анализа в реальном времени (RICAS) для аналитического сопровождения оперативно-розыскной деятельности и досудебного расследования / Д. Ю. Узлов, В. М. Струков, А. Б. Григорович и др. // Право і безпека. - 2015. - № 2 (57). - С. 132–139.Досліджено проблему підвищення ефективності інформаційно-аналітичної роботи в органах внутрішніх справ шляхом створення інтелектуального технологічного інструментарію нового покоління. Проаналізовано сучасний стан інформаційно-аналітичного забезпечення органів внутрішніх справ України та сформульовано його характерні особливості. Виконано огляд зарубіжних автоматизованих засобів інформаційно-аналітичної роботи, виділено їхні переваги і недоліки. Як вирішення сформульованих проблем запропоновано використовувати геоінформаційну інтелектуальну систему кримінального аналізу в реальному часі – Real-time Intelligence crime analytics system (RICAS). Описано її призначення, функціональні можливості, методики виконання кримінального аналізу засобами системи, переваги в порівнянні з існуючими аналогами і новизну.The problem of improving the effectiveness of informational and analytical work within internal affairs agencies through the creation of intelligent technological tools of the new generation is studied in the article. The authors have analyzed the current state of informational and analytical support of Internal Affairs Agencies of Ukraine and have formulated its characteristic features. The overview of foreign automated means of information and analytical work is performed; their advantages and disadvantages are outlined. As a solution of the formulated problems the authors have offered to use geographic and information Real-time Intelligence crime analytics system (RICAS). Its purpose, functionality, methodical techniques of criminal analysis by the means of the system, advantages compared with existing analogues and novelty are described. The system has used methods and algorithms for clustering and classification of Text Mining technology to isolate criminally relevant information together with the technology of Visual Mining in real time, ensuring the ability to perform analytical work on the prevention and investigation of crimes in the automated mode on a qualitatively new level. The RICAS allows us to perform the analysis, processing and presentation of data on a new technological basis; it is designed as an add (shell) of the existing integrated information and search system of Internal Affairs Agencies of Ukraine; and that is essential, it allows while its implementation do not delete the old system or suspend its operation, but simply and painless significantly improve its functionality and efficiency. The RICAS – is the first intelligence system of criminal analysis of data, which brings together in one space the main and the most advanced methods and techniques of criminal analysis and analytical search in real time that can significantly increase the efficiency and effectiveness of solving crimes without delay and previously unsolved crimes.Исследована проблема повышения эффективности информационно-аналитической работы в органах внутренних дел путём создания интеллектуального технологического инструментария нового поколения. Проанализировано современное состояние информационноаналитического обеспечения органов внутренних дел Украины и сформулированы его характерные особенности. Выполнен обзор зарубежных автоматизированных средств информационно-аналитической работы, выделены их достоинства и недостатки. В качестве решения сформулированных проблем предложено использовать геоинформационную интеллектуальную систему криминального анализа в реальном времени – Real-time Intelligence crime analytics system (RICAS). Описаны её назначение, функциональные возможности, методики выполнения криминального анализа средствами системы, преимущества по сравнению с существующими аналогами и новизна

Addressing the Black Box of AI – A Model and Research Agenda on the Co-Constitution of Aging and Artificial Intelligence

Algorithmic technologies and (large) data infrastructures, often referred to as Artificial Intelligence (AI), have received increasing attention from gerontological research in the last decade. While there is much literature that dissects and explores the development, application, and evaluation of AI relevant for gerontology, this article makes a novel contribution by critically engaging with the theorizing in this growing field of research. We observe that gerontology’s engagement with AI is shaped by an interventionist logic that situates AI as a black box for gerontological research. We demonstrate how this black box logic has neglected many aspects of AI as a research topic for gerontology and discuss three classical concepts in gerontology to show how they can be used to open various black boxes of aging and AI in the areas: a) the datafication of aging, b) the political economy of AI and aging, and c) everyday engagements and embodiments of AI in later life. In the final chapter, we propose a model of the co-constitution of aging and AI that makes theoretical propositions to study the relational terrain between aging and AI and hence aims to open the black box of AI in gerontology beyond an interventionist logic.Vera Gallistl’s work on this paper has been funded by the Vienna Science and Technology Fund (WWTF) and by the State of Lower Austria through project ICT20-055 (Grant-ID: 10.47379/ICT20055). Barbara Marshall’s work on this paper has been funded by the Social Science and Humanities Research Council of Canada (435-2017-1343) and the Canadian Institute for Health Research (155188). We acknowledge support by Open Access Publishing Fund of Karl Landsteiner University of Health Sciences, Krems, Austria

ART-XC: A Medium-energy X-ray Telescope System for the Spectrum-R-Gamma Mission

The ART-XC instrument is an X-ray grazing-incidence telescope system in an ABRIXAS-type optical configuration optimized for the survey observational mode of the Spectrum-RG astrophysical mission which is scheduled to be launched in 2011. ART-XC has two units, each equipped with four identical X-ray multi-shell mirror modules. The optical axes of the individual mirror modules are not parallel but are separated by several degrees to permit the four modules to share a single CCD focal plane detector, 1/4 of the area each. The 450-micron-thick pnCCD (similar to the adjacent eROSITA telescope detector) will allow detection of X-ray photons up to 15 keV. The field of view of the individual mirror module is about 18 x 18 arcminutes(exp 2) and the sensitivity of the ART-XC system for 4 years of survey will be better than 10(exp -12) erg s(exp -1) cm(exp -2) over the 4-12 keV energy band. This will allow the ART-XC instrument to discover several thousand new AGNs

Status of ART-XC/SRG Instrument

Spectrum Roentgen Gamma (SRG) is an X-ray astrophysical observatory, developed by Russia in collaboration with Germany. The mission will be launched in March 2016 from Baikonur, by a Zenit rocket with a Fregat booster and placed in a 6-month-period halo orbit around L2. The scientific payload consists of two independent telescopes - a soft-x-ray survey instrument, eROSITA, being provided by Germany and a medium-x-ray-energy survey instrument ART-XC being developed by Russia. ART-XC will consist of seven independent, but co-aligned, telescope modules. The NASA Marshall Space Flight Center (MSFC) is fabricating the flight mirror modules for the ART-XC/SRG. Each mirror module will be aligned with a focal plane CdTe double-sided strip detectors which will operate over the energy range of 6-30 keV, with an angular resolution of less than 1, a field of view of approximately 34 and an expected energy resolution of about 10 percent at 14 keV

Distribution pattern of TLR-2, TLR-4, CD68, CD45R0, interacting with the antigens parodontopatogens in the cells of mucosal gingival in patients with chronic generalized periodontitis

The article analyzes the expression of TLR-2 and TLR-4 receptor of epithelial cells, the distribution of CD68 positive cells and CD45R0 positive T lymphocyte inflammatory infiltrate in the compartments of the gums of patients with chronic generalized periodontitis of medium severity on the background of the initial course of periodontal treatment. Treatment included pharmacological - machining of teeth, tooth roots, periodontal pockets, teaching oral hygiene using the ruler of 'ASEPTA', eliminating areas for retention of microbial plaque, temporary splinting and prosthetics. An expression is derived clinical benefit. Before treatment was determined by high expression of TLR-2 and TLR-4 on the surface of epithelial cells of the gums, and in the inflammatory infiltrate detected a large number of cells of the immune synapse of participants (CD45R0-T lymphocytes and CD68 + macrophages). After treatment significantly decreased expression of TLR-2 and TLR-4 on the surface of epithelial cells of the gums, while in his own plate of mucous membrane gums preserved population CD68 + macrophages, CD45R0 T lymphocytes, indicating the reduction of the barrier function of the epithelium and capable to run the aggravation of inflammation in the case of excessive growth parodontopatogenov in the area of periodontal pockets.В статье проведен анализ характера экспрессии TLR-2 и TLR-4 рецепторов зпителиоцитов, распределения CD68 позитивных клеток и CD45RO позитивных Т лимфоцитов воспалительного инфильтрата в компартментах десны больных хроническим генерализованным пародонтитом средней степени тяжести на фоне начального курса пародонтологического лечения. Лечение включало фармако - механическую обработку зубов, корней зубов, пародонтальных карманов, обучение гигиене полости рта с использованием линейки средств «АСЕПТА». устранения зон ретенции для микробного налета, временное шинирование и протезирование зубов. Получен выраженный клинический эффект. До лечения определялся высокий уровень экспрессии TLR-2 и TLR-4 на поверхности зпителиоцитов десны, а в воспалительном инфильтрате зафиксировано большое количество клеток участников иммунного синапса (С045Р0-Т-лимф0циты и CD68+ макрофаги). После лечения статистически значимо уменьшилась экспрессия TLR-2 и TLR-4 на поверхности эпителиоцитов десны, при этом в собственной пластинке слизистой оболочки десны сохранились популяции CD68+ макрофагов CD45RO Т лимфоцитов, свидетельствующие о снижение барьерной функции эпителия и способные запустить обострение воспаления в случае избыточного роста пародонтопатогенов в зоне пародонтальных карманов

The ART-XC telescope on board the SRG observatory

ART-XC (Astronomical Roentgen Telescope - X-ray Concentrator) is the hard X-ray instrument with grazing incidence imaging optics on board the Spektr-Roentgen-Gamma (SRG) observatory. The SRG observatory is the flagship astrophysical mission of the Russian Federal Space Program, which was successively launched into orbit around the second Lagrangian point (L2) of the Earth-Sun system with a Proton rocket from the Baikonur cosmodrome on 13 July 2019. The ART-XC telescope will provide the first ever true imaging all-sky survey performed with grazing incidence optics in the 4-30 keV energy band and will obtain the deepest and sharpest map of the sky in the energy range of 4-12 keV. Observations performed during the early calibration and performance verification phase as well as during the on-going all-sky survey that started on 12 Dec. 2019 have demonstrated that the in-flight characteristics of the ART-XC telescope are very close to expectations based on the results of ground calibrations. Upon completion of its 4-year all-sky survey, ART-XC is expected to detect ~5000 sources (~3000 active galactic nuclei, including heavily obscured ones, several hundred clusters of galaxies, ~1000 cataclysmic variables and other Galactic sources), and to provide a high-quality map of the Galactic background emission in the 4-12 keV energy band. ART-XC is also well suited for discovering transient X-ray sources. In this paper, we describe the telescope, results of its ground calibrations, major aspects of the mission, the in-flight performance of ART-XC and first scientific results.Comment: 19 pages, 30 figures, accepted for publication in Astronomy and Astrophysic

ART-XC Instrument on Board of the SRG Mission

No abstract availabl

AUG_hairpin: prediction of a downstream secondary structure influencing the recognition of a translation start site

<p>Abstract</p> <p>Background</p> <p>The translation start site plays an important role in the control of translation efficiency of eukaryotic mRNAs. The recognition of the start AUG codon by eukaryotic ribosomes is considered to depend on its nucleotide context. However, the fraction of eukaryotic mRNAs with the start codon in a suboptimal context is relatively large. It may be expected that mRNA should possess some features providing efficient translation, including the proper recognition of a translation start site. It has been experimentally shown that a downstream hairpin located in certain positions with respect to start codon can compensate in part for the suboptimal AUG context and also increases translation from non-AUG initiation codons. Prediction of such a compensatory hairpin may be useful in the evaluation of eukaryotic mRNA translation properties.</p> <p>Results</p> <p>We evaluated interdependency between the start codon context and mRNA secondary structure at the CDS beginning: it was found that a suboptimal start codon context significantly correlated with higher base pairing probabilities at positions 13 – 17 of CDS of human and mouse mRNAs. It is likely that the downstream hairpins are used to enhance translation of some mammalian mRNAs <it>in vivo</it>. Thus, we have developed a tool, <it>AUG_hairpin</it>, to predict local stem-loop structures located within the defined region at the beginning of mRNA coding part. The implemented algorithm is based on the available published experimental data on the CDS-located stem-loop structures influencing the recognition of upstream start codons.</p> <p>Conclusion</p> <p>An occurrence of a potential secondary structure downstream of start AUG codon in a suboptimal context (or downstream of a potential non-AUG start codon) may provide researchers with a testable assumption on the presence of additional regulatory signal influencing mRNA translation initiation rate and the start codon choice. <it>AUG_hairpin</it>, which has a convenient Web-interface with adjustable parameters, will make such an evaluation easy and efficient.</p