Photometry and astrometry with JWST -- II. NIRCam distortion correction

In preparation to make the most of our own planned James Webb Space Telescope investigations, we take advantage of publicly available calibration and early-science observations to independently derive and test a geometric-distortion solution for NIRCam detectors. Our solution is able to correct the distortion to better than ~0.2 mas. Current data indicate that the solution is stable and constant over the investigated filters, temporal coverage, and even over the available filter combinations. We successfully tested our geometric-distortion solution in three cases: (i) field-object decontamination of M 92 field; (ii) estimate of internal proper motions of M 92; and (iii) measurement of the internal proper motions of the Large Magellanic Cloud system. To our knowledge, the here-derived geometric-distortion solution for NIRCam is the best available and we publicly release it, as many other investigations could potentially benefit from it. Along with our geometric-distortion solution, we also release a Python tool to convert the raw-pixels coordinates of each detector into distortion-free positions, and also to put all the ten detectors of NIRCam into a common reference system.Comment: 13 pages, 12 figures (6 in low resolution), 3 tables. Accepted for publication on February 21st, 2023, by Astronomische Nachrichten (Astronomical Notes). Distortion correction software available at https://web.oapd.inaf.it/bedin/files/PAPERs_eMATERIALs/JWST/Paper_02/Python

The broadening of the main sequence in the open cluster M38

Our recent multi-band photometric study of the colour width of the lower main sequence of the open cluster M37 has revealed the presence of a sizeable initial chemical composition spread in the cluster. If initial chemical composition spreads are common amongst open clusters, this would have major implications for cluster formation models and the foundation of the chemical tagging technique. Here we present a study of the unevolved main sequence of the open cluster M38, employing Gaia DR3 photometry and astrometry, together with newly acquired Sloan photometry. We have analysed the distribution of the cluster's lower main sequence stars with a differential colour-colour diagram made of combinations of Gaia and Sloan magnitudes, like in the study of M37. We employed synthetic stellar populations to reproduce the observed trend of M38 stars in this diagram, and found that the observed colour spreads can be explained simply by the combined effect of differential reddening across the face of the cluster and the presence of unresolved binaries. There is no need to include in the synthetic sample a spread of initial chemical composition as instead necessary to explain the main sequence of M37. Further photometric investigations like ours, as well as accurate differential spectroscopic analyses on large samples of open clusters, are necessary to understand whether chemical abundance spreads are common among the open cluster population.Comment: 8 pages, 10 figures. Accepted for publication in MNRAS on 2023, June 0

Signature of a chemical spread in the open cluster M37

Recent Gaia photometry of the open cluster M37 have disclosed the existence of an extended main-sequence turn off -- like in Magellanic clusters younger than about 2 Gyr -- and a main sequence that is broadened in colour beyond what is expected from the photometric errors, at magnitudes well below the region of the extended turn off, where neither age differences nor rotation rates (the candidates to explain the extended turn off phenomenon) are expected to play a role. Moreover, not even the contribution of unresolved binaries can fully explain the observed broadening. We investigated the reasons behind this broadening by making use of synthetic stellar populations and differential colour-colour diagrams using a combination of Gaia and Sloan filters. From our analysis we have concluded that the observed colour spread in the Gaia colour-magnitude diagram can be reproduced by a combination of either a metallicity spread Delta[Fe/H] ~ 0.15 plus a differential reddening across the face of the cluster spanning a total range DeltaE (B - V) ~ 0.06, or a spread of the initial helium mass fraction DeltaY ~ 0.10 plus a smaller range of reddening DeltaE (B - V) ~ 0.03. High-resolution differential abundance determinations of a sizeable sample of cluster stars are necessary to confirm or exclude the presence of a metal abundance spread. Our results raise the possibility that also individual open clusters, like globular clusters and massive star clusters, host stars born with different initial chemical compositions.Comment: 10 pages, 10 figures. Accepted for publication in MNRAS on 2022, August 31, manuscript ID. MN-22-2637-M

Photometry and astrometry with JWST -- III. A NIRCam-Gaia DR3 analysis of the open cluster NGC 2506

In the third paper of this series aimed at developing the tools for analysing resolved stellar populations using the cameras on board of the James Webb Space Telescope (JWST), we present a detailed multi-band study of the 2 Gyr Galactic open cluster NGC 2506. We employ public calibration data-sets collected in multiple filters to: (i) derive improved effective Point Spread Functions (ePSFs) for ten NIRCam filters; (ii) extract high-precision photometry and astrometry for stars in the cluster, approaching the main-sequence (MS) lower mass of ~0.1 Msun; and (iii) take advantage of the synergy between JWST and Gaia DR3 to perform a comprehensive analysis of the cluster's global and local properties. We derived a MS binary fraction of ~57.5 %, extending the Gaia limit (~0.8 Msun) to lower masses (~0.4 Msun) with JWST. We conducted a study on the mass functions (MFs) of NGC 2506, mapping the mass segregation with Gaia data, and extending MFs to lower masses with the JWST field. We also combined information on the derived MFs to infer an estimate of the cluster present-day total mass. Lastly, we investigated the presence of white dwarfs (WDs) and identified a strong candidate. However, to firmly establish its cluster membership, as well as that of four other WD candidates and of the majority of faint low-mass MS stars, further JWST equally deep observations will be required. We make publicly available catalogues, atlases, and the improved ePSFs.Comment: 20 pages, 17 figures (5 in low resolution), 4 tables. Accepted for publication in MNRAS on August 5, 2023. PSF models, catalogs and stacked images are publicly available at https://web.oapd.inaf.it/bedin/files/PAPERs_eMATERIALs/JWST/Paper_03

Exploring the origin of the extended main sequence turn off in M37 through the white dwarf cooling sequence

We use new observations from the Canada-France-Hawaii Telescope to study the white dwarf cooling sequence of the open cluster M37, a cluster that displays an extended main sequence turn-off and, according to a recent photometric analysis, also a spread of initial chemical composition. By taking advantage of a first epoch collected in 1999 with the same telescope, we have been able to calculate proper motions for sources as faint as g ~ 26 (about ~ 6 magnitudes fainter than the Gaia limit), allowing us to separate cluster members from field stars. This has enabled us to isolate a sample of the white dwarf population of M37, reaching the end of the cooling sequence (at g ~ 23.5). The here-derived atlas and calibrated catalogue of the sources in the field of view is publicly released as supplementary on-line material. Finally, we present an exhaustive comparison of the white dwarf luminosity function with theoretical models, which has allowed us to exclude the age-spread scenario as the main responsible for the extended turnoff seen in the cluster colour-magnitude-diagram.Comment: 10 pages, 13 figures. Accepted for publication in MNRAS on 2023, June 1

Impact of immune parameters and immune dysfunctions on the prognosis of patients with chronic lymphocytic leukemia

SIMPLE SUMMARY: In chronic lymphocytic leukemia (CLL), immune alterations—affecting both the innate and adaptive immunity—are very common. As a clinical consequence, patients with CLL frequently present with autoimmune phenomena, increased risk of infections and second malignancies. The aim of this review article is to present available data on CLL-associated alterations of immune parameters that correlate with known prognostic markers and with clinical outcome. Also, data on the impact of immune-related clinical manifestations on the prognosis of patients with CLL will be discussed. ABSTRACT: Chronic lymphocytic leukemia (CLL) is characterized by a wide spectrum of immune alterations, affecting both the innate and adaptive immunity. These immune dysfunctions strongly impact the immune surveillance, facilitate tumor progression and eventually affect the disease course. Quantitative and functional alterations involving conventional T cells, γδ T cells, regulatory T cells, NK and NKT cells, and myeloid cells, together with hypogammaglobulinemia, aberrations in the complement pathways and altered cytokine signature have been reported in patients with CLL. Some of these immune parameters have been shown to associate with other CLL-related characteristics with a known prognostic relevance or to correlate with disease prognosis. Also, in CLL, the complex immune response dysfunctions eventually translate in clinical manifestations, including autoimmune phenomena, increased risk of infections and second malignancies. These clinical issues are overall the most common complications that affect the course and management of CLL, and they also may impact overall disease prognosis

Impact of immune parameters and immune dysfunctions on the prognosis of patients with chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) is characterized by a wide spectrum of immune alterations, affecting both the innate and adaptive immunity. These immune dysfunctions strongly impact the immune surveillance, facilitate tumor progression and eventually affect the disease course. Quantitative and functional alterations involving conventional T cells, γδ T cells, regulatory T cells, NK and NKT cells, and myeloid cells, together with hypogammaglobulinemia, aberrations in the complement pathways and altered cytokine signature have been reported in patients with CLL. Some of these immune parameters have been shown to associate with other CLL‐related characteristics with a known prognostic relevance or to correlate with disease prognosis. Also, in CLL, the complex immune response dysfunctions eventually translate in clinical manifestations, including autoimmune phenomena, increased risk of infections and second malignancies. These clinical issues are overall the most common complications that affect the course and management of CLL, and they also may impact overall disease prognosis

HST astrometry of the closest Brown Dwarfs -- II. Improved parameters and constraints on a third body

Located at less than 2pc away, Luhman16AB (WISE.J104915.57-531906.1) is the closest pair of brown dwarfs and third closest `stellar' system to Earth. An exoplanet candidate in the Luhman16 binary system was reported in 2017 based on a weak astrometric signature in the analysis of 12 HST epochs. An additional epoch collected in 2018 and re-analysis of the data with more advanced methods further increased the significance level of the candidate, consistent with a Neptune-mass exoplanet orbiting one of the Luhman16 brown dwarf components. We report the joint analysis of these previous data together with two new astrometric HST epochs we obtained to confirm or disprove this astrometric signature. Our new analysis rules out presence of a planet orbiting one component of the Luhman16AB system for masses M > 1.5 M_Nep (Neptune masses) and periods between 400 and 5000 days. However, the presence of third bodies with masses M < 3 M_Nep and periods between 2 and 400 days (~1.1yrs) can not be excluded. Our measurements make significant improvements to the characterization of this sub-stellar binary, including its mass-ratio 0.8305+/-0.0006, individual component masses 35.4+/-0.2 M_Jup and 29.4+/-0.2 M_Jup (Jupiter masses), and parallax distance 1.9960pc +/- 50AU. Comparison of the masses and luminosities of Luhman16AB to several evolutionary models shows persistent discrepancies in the ages of the two components, but strengthens the case that this system is a member of the 510+/-95 Myr Oceanus Moving Group.Comment: 17 pages, 8+A1 figures. Accepted for publication on Astronomische Nachrichten on 10th January 2024 available https://onlinelibrary.wiley.com/doi/10.1002/asna.20230158 on-line supplementary material and animations https://web.oapd.inaf.it/bedin/files/PAPERs_eMATERIALs/Luh16AB_II

A new case manager for diabetic patients: a pilot observational study of the role of community pharmacists and pharmacy services in the case management of diabetic patients

The adherence of type 2 diabetes mellitus (DM2) patients with an individual care plan (ICP) is often not satisfactory, nor does it allow for a significant improvement in outcome, because of poor accessibility to services, poor integration of pathway articulations, poor reconciliation with the patient's life, or the lack of a constant reference person. The purpose of this study was to evaluate the contribution of community pharmacists and pharmacy services in improving adherence with periodic controls in DM2. The study was conducted at a rural pharmacy. A sample of 40 patients was calculated with respect to a historical cohort and subsequently enrolled. Clinical and personal data were collected in an electronic case report form. Pharmacists acting as a case manager followed patients carrying out their ICP developed by an attending physician. Some of the activities foreseen by the ICP, such as electrocardiogram, fundus examination, and self-analysis of blood and urine, were carried out directly in the pharmacy by the pharmacist through the use of telemedicine services and point of care units. Activities that could not be performed in the pharmacy were booked by the pharmacist at the accredited units. Examination results were electronically reported by the pharmacist to the attending physician. The primary endpoint was the variation in patient adherence with the ICP compared to a historical cohort. Secondary endpoints were variation in waiting time for the examinations, mean percentage change in glycated hemoglobin (HbA1c) and low-density lipoprotein (LDL) cholesterol levels and blood pressure, impact on healthcare-related costs, and perceived quality of care. Adherence to the ICP significantly increased. Waiting times were reduced and clinical outcomes improved with conceivable effects on costs. Patients appreciated the easier access to services. Community pharmacists and pharmacy services represent ideal actors and context that, integrated in the care network, can really favor ICP adherence and obtain daily morbidity reduction and cost savings through proper disease control and an early diagnosis of complications

Automatic Abstraction in SMT-Based Unbounded Software Model Checking

Software model checkers based on under-approximations and SMT solvers are very successful at verifying safety (i.e. reachability) properties. They combine two key ideas -- (a) "concreteness": a counterexample in an under-approximation is a counterexample in the original program as well, and (b) "generalization": a proof of safety of an under-approximation, produced by an SMT solver, are generalizable to proofs of safety of the original program. In this paper, we present a combination of "automatic abstraction" with the under-approximation-driven framework. We explore two iterative approaches for obtaining and refining abstractions -- "proof based" and "counterexample based" -- and show how they can be combined into a unified algorithm. To the best of our knowledge, this is the first application of Proof-Based Abstraction, primarily used to verify hardware, to Software Verification. We have implemented a prototype of the framework using Z3, and evaluate it on many benchmarks from the Software Verification Competition. We show experimentally that our combination is quite effective on hard instances.Comment: Extended version of a paper in the proceedings of CAV 201