Asymptotic safety in the dark

We explore the Renormalization Group flow of massive uncharged fermions -- a candidate for dark matter -- coupled to a scalar field through a Higgs portal. We find that fermionic fluctuations can lower the bound on the scalar mass that arises from vacuum stability. Further, we discuss that despite the perturbative nonrenormalizability of the model, it could be ultraviolet complete at an asymptotically safe fixed point. In our approximation, this simple model exhibits two mechanisms for asymptotic safety: a balance of fermionic and bosonic fluctuations generates a fixed point in the scalar self-interaction; asymptotic safety in the portal coupling is triggered through a balance of canonical scaling and quantum fluctuations. As a consequence of asymptotic safety in the dark sector, the low-energy value of the portal coupling could become a function of the dark fermion mass and the scalar mass, thereby reducing the viable parameter space of the model.Comment: 16 pages plus appendix; 5 figure

Bottomonium suppression in an open quantum system using the quantum trajectories method

We solve the Lindblad equation describing the Brownian motion of a Coulombic heavy quark-antiquark pair in a strongly coupled quark-gluon plasma using the highly efficient Monte Carlo wave-function method. The Lindblad equation has been derived in the framework of pNRQCD and fully accounts for the quantum and non-Abelian nature of the system. The hydrodynamics of the plasma is realistically implemented through a 3+1D dissipative hydrodynamics code. We compute the bottomonium nuclear modification factor and compare with the most recent LHC data. The computation does not rely on any free parameter, as it depends on two transport coefficients that have been evaluated independently in lattice QCD. Our final results, which include late-time feed down of excited states, agree well with the available data from LHC 5.02 TeV PbPb collisions.Comment: 42 pages, 18 figure

Heavy quarkonium dynamics at next-to-leading order in the binding energy over temperature

Using the potential non-relativistic quantum chromodynamics (pNRQCD) effective field theory, we derive a Lindblad equation for the evolution of the heavy-quarkonium reduced density matrix that is accurate to next-to-leading order (NLO) in the ratio of the binding energy of the state to the temperature of the medium. The resulting NLO Lindblad equation can be used to more reliably describe heavy-quarkonium evolution in the quark-gluon plasma at low temperatures compared to the leading-order truncation. For phenomenological application, we numerically solve the resulting NLO Lindblad equation using the quantum trajectories algorithm. To achieve this, we map the solution of the three-dimensional Lindblad equation to the solution of an ensemble of one-dimensional Schr\"odinger evolutions with Monte-Carlo sampled quantum jumps. Averaging over the Monte-Carlo sampled quantum jumps, we obtain the solution to the NLO Lindblad equation without truncation in the angular momentum quantum number of the states considered. We also consider the evolution of the system using only the complex effective Hamiltonian without stochastic jumps and find that this provides a reliable approximation for the ground state survival probability at LO and NLO. Finally, we make comparisons with our prior leading-order pNRQCD results and experimental data available from the ATLAS, ALICE, and CMS collaborations.Comment: 40 pages, 8 figure

CXCR4 Expression in Prostate Cancer Progenitor Cells

Tumor progenitor cells represent a population of drug-resistant cells that can survive conventional chemotherapy and lead to tumor relapse. However, little is known of the role of tumor progenitors in prostate cancer metastasis. The studies reported herein show that the CXCR4/CXCL12 axis, a key regulator of tumor dissemination, plays a role in the maintenance of prostate cancer stem-like cells. The CXCL4/CXCR12 pathway is activated in the CD44+/CD133+ prostate progenitor population and affects differentiation potential, cell adhesion, clonal growth and tumorigenicity. Furthermore, prostate tumor xenograft studies in mice showed that a combination of the CXCR4 receptor antagonist AMD3100, which targets prostate cancer stem-like cells, and the conventional chemotherapeutic drug Taxotere, which targets the bulk tumor, is significantly more effective in eradicating tumors as compared to monotherapy

Role of genetic testing for inherited prostate cancer risk: Philadelphia prostate cancer consensus conference 2017

Purpose: Guidelines are limited for genetic testing for prostate cancer (PCA). The goal of this conference was to develop an expert consensus-dri

Bottomonium observables in an open quantum system using the quantum trajectories method

We solve the Lindblad equation describing the Brownian motion of a Coulombic heavy quark-antiquark pair in a strongly coupled quark gluon plasma using the Monte Carlo wave function method. The Lindblad equation has been derived in the framework of pNRQCD and fully accounts for the quantum and non-Abelian nature of the system. The hydrodynamics of the plasma is realistically implemented through a 3+1D dissipative hydrodynamics code. We compute the bottomonium nuclear modification factor and elliptic flow and compare with the most recent LHC data. The computation does not rely on any free parameter, as it depends on two transport coefficients that have been evaluated independently in lattice QCD. Our final results, which include late-time feed down of excited states, agree well with the available data from LHC 5.02 TeV PbPb collisions

Transport coefficients from in-medium quarkonium dynamics

The in-medium dynamics of heavy particles are governed by transport coefficients. The heavy quark momentum diffusion coefficient, kappa, is an object of special interest in the literature, but one which has proven notoriously difficult to estimate, despite the fact that it has been computed by weak-coupling methods at next-to-leading order accuracy, and by lattice simulations of the pure SU(3) gauge theory. Another coefficient, gamma, has been recently identified. It can be understood as the dispersive counterpart of kappa. Little is known about gamma. Both kappa and gamma arc, however, of foremost importance in heavy quarkonium physics as they entirely determine the in and out of equilibrium dynamics of quarkonium in a medium, if the evolution of the density matrix is Markovian, and the motion, quantum Brownian; the medium could be a strongly or weakly coupled plasma. In this paper, using the relation between kappa, gamma and the quarkonium in-medium width and mass shift respectively, we evaluate the two coefficients from existing 2 + 1 flavor lattice QCD data. The resulting range for kappa is consistent with earlier determinations, the one for gamma is the first nonperturbative determination of this quantity.peerReviewe