2,449 research outputs found

    350 Micron Observations of Ultraluminous Infrared Galaxies at Intermediate Redshifts

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    We present 350micron observations of 36 ultraluminous infrared galaxies (ULIRGs) at intermediate redshifts (0.089 <= z <= 0.926) using the Submillimeter High Angular Resolution Camera II (SHARC-II) on the Caltech Submillimeter Observatory (CSO). In total, 28 sources are detected at S/N >= 3, providing the first flux measurements longward of 100micron for a statistically significant sample of ULIRGs in the redshift range of 0.1 < z < 1.0. Combining our 350micron flux measurements with the existing IRAS 60 and 100micron data, we fit a single-temperature model to the spectral energy distribution (SED), and thereby estimate dust temperatures and far-IR luminosities. Assuming an emissivity index of beta = 1.5, we find a median dust temperature and far-IR luminosity of Td = 42.8+-7.1K and log(Lfir/Lsolar) = 12.2+-0.5, respectively. The far-IR/radio correlation observed in local star-forming galaxies is found to hold for ULIRGs in the redshift range 0.1 < z < 0.5, suggesting that the dust in these sources is predominantly heated by starbursts. We compare the far-IR luminosities and dust temperatures derived for dusty galaxy samples at low and high redshifts with our sample of ULIRGs at intermediate redshift. A general Lfir-Td relation is observed, albeit with significant scatter, due to differing selection effects and variations in dust mass and grain properties. The relatively high dust temperatures observed for our sample compared to that of high-z submillimeter-selected starbursts with similar far-IR luminosities suggest that the dominant star formation in ULIRGs at moderate redshifts takes place on smaller spatial scales than at higher redshifts.Comment: (24 pages in preprint format, 1 table, 7 figures, accepted for publication in ApJ

    Determining the optimal length of regulatory guarantee: A Length-of-Contract Auction

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    One of the biggest challenges in the area of infrastructure investment is the provision of funding to finance activities. This paper presents an auction design which can reduce the financing cost of infrastructure investments by allowing the length of the regulatory funding period to be determined via an auction. The auction allows bidders to submit bids against a payment for periods of varying length. Thus instead of, for example, a fixed 20-year contract period, some bidders might want to bid for financing over a longer period, say 25 or 30 years. This can be desirable in terms of securing more favourable terms in the financial markets. Our auction design can secure efficiency and lower financing costs. Our auction is motivated by the auctions currently being undertaken by the UK energy regulator (Ofgem) for financing offshore transmission assets. Although the auction was designed with electricity transmission in mind, the auction could be used in other areas of infrastructure investment

    Safety of the SQ tree sublingual immunotherapy tablet: Pooled safety analysis of clinical trials

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    Background The standardized quality (SQ) tree sublingual immunotherapy (SLIT)-tablet has recently been approved for treatment of tree pollen allergy. Healthcare workers should be provided with detailed safety data for clinical use. Objective To assess the tolerability and safety of the SQ tree SLIT-tablet (12 SQ-Bet) in adults and adolescents. Methods Safety data were pooled from three double-blinded, randomized, placebo-controlled trials (2 phase-II/1 phase-III) including adults and adolescents 12-65 years with allergic rhinitis and/or conjunctivitis treated before and during one pollen season once-daily with 12 SQ-Bet (n = 471) or placebo (n = 458): EudraCT no: 2012-000031-59; NCT02481856; EudraCT 2015-004821-15. Results The most frequently reported investigational medicinal product (IMP)-related AEs with 12 SQ-Bet were oral pruritis (39% of subjects) and throat irritation (29%). IMP-related AEs were mainly mild or moderate in severity, and the majority resolved without treatment and did not lead to treatment interruption/discontinuation. With 12 SQ-Bet, oral pruritus was more frequent among subjects with pollen food syndrome (PFS) (45%) than without PFS (29%). The 12 SQ-Bet did not seem to induce an increased risk of asthma: 7 events were reported in 7 subjects with 12 SQ-Bet and 11 in 10 subjects with placebo. No differences were seen in the risk of moderate-to-severe IMP-related AEs regardless of age, PFS status and asthma medical history. Conclusions The 12 SQ tree SLIT-tablet was well tolerated in tree pollen allergic subjects with no major safety concerns detected. This safety profile supports daily at-home sublingual administration once the first dose is tolerated when administered under medical supervision.Peer reviewe
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