Expanding on Leadership and Professional Skills for a Girls Build Summer Academy

The construction industry has historically been male-dominated. Despite efforts by organizations and companies to encourage women to join the industry, there has been little progress in encouraging more women to enter the industry and getting them to stay. The construction management program at California Polytechnic State University in San Luis Obispo is developing and hosting a Girls Build Summer Academy to familiarize and encourage high school girls to explore construction as a career path. One segment of this boot camp includes leadership modules that will give the girls confidence and the skills they need to be successful leaders in construction. Through research, surveys, and interviews the three top categories to teach young girls to be successful in construction were decided. The boot camp will focus on exposure to role models and career paths in construction, education on the importance of mentorship, and show them the importance of effective communication

Ultrastructural Cytochemistry of the Tegumental Surface Membrane of Paragonimus Kellicotti

Paper by Francis M. Gress and Richard D. Lumsde

Archaean and Proterozoic diamond growth from contrasting styles of large-scale magmatism

Precise dating of diamond growth is required to understand the interior workings of the early Earth and the deep carbon cycle. Here we report Sm-Nd isotope data from 26 individual garnet inclusions from 26 harzburgitic diamonds from Venetia, South Africa. Garnet inclusions and host diamonds comprise two compositional suites formed under markedly different conditions and define two isochrons, one Archaean (2.95 Ga) and one Proterozoic (1.15 Ga). The Archaean diamond suite formed from relatively cool fluid-dominated metasomatism during rifting of the southern shelf of the Zimbabwe Craton. The 1.8 billion years younger Proterozoic diamond suite formed by melt-dominated metasomatism related to the 1.1 Ga Umkondo Large Igneous Province. The results demonstrate that resolving the time of diamond growth events requires dating of individual inclusions, and that there was a major change in the magmatic processes responsible for harzburgitic diamond formation beneath Venetia from the Archaean to the Proterozoic

Лечение артериальной гипертензии в преклонном возрасте: от отрицания до признания необходимости

Представлен анализ результатов клинических исследований антигипертензивной терапии у пожилых пациентов, позволяющий сделать заключение о целесообразности ее проведения даже после достижения 80−летнего возраста.The analysis of the findings of clinical research of antihypertensive therapy in elderly patients, which allowed to conclude about the necessity about the expediency of its administration even in patients over 80, is presented

Comprehensive Analysis of Cellular Galectin-3 Reveals No Consistent Oncogenic Function in Pancreatic Cancer Cells

Galectin-3 (Gal-3), a 31 kDa member of the family of beta-galactoside-binding proteins, has been implicated in the progression of different human cancers. However, the proposed roles differ widely, ranging from tumor-promoting cellular functions and negative impact on patient prognosis to tumor-suppressive properties and positive prognostic impact. We and others have previously identified Gal-3 as overexpressed in pancreatic cancer as compared to chronic pancreatitis and normal pancreatic tissue. The purpose of this study was thus the comprehensive analysis of putative cellular functions of Gal-3 by transient as well as stable silencing or overexpression of Gal-3 in a panel of 6 well-established pancreatic cancer cell lines. Our results confirm that galectin-3 is upregulated at the mRNA level in pancreatic cancer and strongly expressed in the majority of pancreatic cancer cell lines. In individual cell lines, transient knockdown of Gal-3 expression resulted in moderate inhibitory effects on proliferation, migration or anchorage-independent growth of the cells, but these effects were not consistent across the spectrum of analyzed cell lines. Moreover, functional effects of the modulation of Gal-3 expression were not observed in stable knockdown or overexpression approaches in vitro and did not alter the growth characteristics of nude mouse xenograft tumors in vivo. Our data thus do not support a direct functional role of Gal-3 in the malignant transformation of pancreatic epithelial cells, although paracrine or systemic effects of Gal-3 expression are not excluded