Propranolol for Treatment of Infantile Hemangioma: Efficacy and Effect on Pediatric Growth and Development

Purpose. Propranolol has been successful in treating problematic infantile hemangiomas (IH) but concerns regarding its effect on normal growth and development have been raised. This study examines physical growth, developmental milestones, and human growth hormone (hGH) levels in infants receiving propranolol for problematic IH. Method. Monthly heights and weights of children undergoing propranolol therapy for IH were prospectively collected and tabulated. Data analysis and comparison to World Health Organization (WHO) weight-for-age and weight-to-length z-scores was performed. Questionnaires regarding milestones, efficacy, and guardian satisfaction were performed, and a combination of both chart results and phone conducted surveys was tabulated. Serum from a small representative cohort of age-matched children with IH treated and not treated with propranolol was collected. Results. A total of 185 children receiving propranolol therapy between 2008 and 2013 for IH were assigned to this study. The children were divided into two cohorts based on the presence of comorbidities or risk factors that may affect growth and development (n = 142 no comorbidities, n = 43 with comorbidities). Neither cohort demonstrated deviation from normal weight in comparison to WHO normative data. There was a significant deviation for BMI-for-age and weight-for-age z-scores in our population, especially in patients on propranolol for more than 7 months. Based on data from participants, via either completed questionnaires or chart results, most children met their developmental milestones at or before target ages, regardless of the presence of comorbidities. Eighty percent of guardians noticed clinical improvement of the IH, with 91% either happy about or neutral to using the medication. hGH levels were higher in patients receiving propranolol therapy, but not significantly different. Conclusion. Propranolol therapy is effective and well tolerated in the treatment of infantile hemangiomas. This study suggests that propranolol does not impair growth and has no impact on normal pediatric development

Footnotes to Disciples History

From the mid 1950s through the 1990s, DCHS printed short publications to remind its readers about the importance of the past. The series included reprints as well as new historical studies. Footnotes to Disciples History collects this wide-ranging series into one volume. ⁃ Rice Haggard\u27s An Address to the Different Religious Societies, on the sacred import of the Christian Name (1804) ⁃ John M. Imbler\u27s Beyond Buffalo: Alexander Campbell on Education for Ministry (1992) ⁃ Report of the Proceedings of a General Meeting of Messengers from Thirteen Congregations (J.T. McVay and Alexander Campbell, 1834) ⁃ William A. Gerrards\u27s Christian Unity, Our Heritage (1986) ⁃ Alexander Campbell\u27s Lunenburg Letter (1837) ⁃ Eva Jean Wrather\u27s Alexander Campbell and His Relevance for Today (1959) ⁃ Perry Gresham\u27s The Broncho That Would Not Be Broken (1986)https://digitalcommons.acu.edu/acu_library_books/1011/thumbnail.jp

Cumulative and Differential Effects of Early Child Care and Middle Childhood Out-of-School Time on Adolescent Functioning.

Effects associated with early child care and out-of-school time (OST) during middle childhood were examined in a large sample of U.S. adolescents (N = 958). Both higher quality early child care AND more epochs of organized activities (afterschool programs and extracurricular activities) during middle childhood were linked to higher academic achievement at age 15. Differential associations were found in the behavioral domain. Higher quality early child care was associated with fewer externalizing problems, whereas more hours of early child care was linked to greater impulsivity. More epochs of organized activities was associated with greater social confidence. Relations between early child care and adolescent outcomes were not mediated or moderated by OST arrangements in middle childhood, consistent with independent, additive relations of these nonfamilial settings

Top A_FB at the Tevatron vs. charge asymmetry at the LHC in chiral U(1) flavor models with flavored Higgs doublets

We consider the top forward-backward (FB) asymmetry at the Tevatron and top charge asymmetry at the LHC within chiral U(1)^\prime models with flavor-dependent U(1)^\prime charges and flavored Higgs fields, which were introduced in the ref. [65]. The models could enhance not only the top forward-backward asymmetry at Tevatron, but also the top charge asymmetry at LHC, without too large same-sign top pair production rates. We identify parameter spaces for the U(1)^\prime gauge boson and (pseudo)scalar Higgs bosons where all the experimental data could be accommodated, including the case with about 125 GeV Higgs boson, as suggested recently by ATLAS and CMS.Comment: 11 pages, 6 figures, figures and discussion adde

Scalar-mediated ttˉt\bar t forward-backward asymmetry

A large forward-backward asymmetry in $t\bar t$ production, for large invariant mass of the $t\bar t$ system, has been recently observed by the CDF collaboration. Among the scalar mediated mechanisms that can explain such a large asymmetry, only the t-channel exchange of a color-singlet weak-doublet scalar is consistent with both differential and integrated $t\bar t$ cross section measurements. Constraints from flavor changing processes dictate a very specific structure for the Yukawa couplings of such a new scalar. No sizable deviation in the differential or integrated $t\bar t$ production cross section is expected at the LHC.Comment: 22 pages, 1 figure and 2 tables. v2: Corrected Eqs.(50,51,74), adapted Fig.1, Tab.1 and relevant discussions. Extended discussion of top decay and single to

Noether Symmetry Approach in "Cosmic Triad" Vector Field Scenario

To realize the accelerations in the early and late periods of our universe, we need to specify potentials for the dominant fields. In this paper, by using the Noether symmetry approach, we try to find suitable potentials in the "cosmic triad" vector field scenario. Because the equation of state parameter of dark energy has been constrained in the range of $-1.21\leq \omega\leq -0.89$ by observations, we derive the Noether conditions for the vector field in quintessence, phantom and quintom models, respectively. In the first two cases, constant potential solutions have been obtained. What is more, a fast decaying point-like solution with power-law potential is also found for the vector field in quintessence model. For the quintom case, we find an interesting constraint $\tilde{C}V_{p}'=-CV_{q}'$ on the field potentials, where $C$ and $\tilde{C}$ are constants related to the Noether symmetry.Comment: 15 pages, no figures, accepted by Classical and Quantum Gravity

Top quark forward-backward asymmetry in R-parity violating supersymmetry

The interaction of bottom squark-mediated top quark pair production, occurring in the R-parity violating minimal supersymmetric standard model (MSSM), is proposed as an explanation of the anomalously large $t\bar{t}$ forward-backward asymmetry (FBA) observed at the Tevatron. We find that this model can give a good fit to top quark data, both the inclusive and invariant mass-dependent asymmetries, while remaining consistent (at the 2-$\sigma$ level) with the total and differential production cross-sections. The scenario is challenged by strong constraints from atomic parity violation (APV), but we point out an extra diagram for the effective down quark-Z vertex, involving the same coupling constant as required for the FBA, which tends to weaken the APV constraint, and which can nullify it for reasonable values of the top squark masses and mixing angle. Large contributions to flavor-changing neutral currents can be avoided if only the third generation of sparticles is light.Comment: 24 pages, 7 figures. v3: included LHC top production cross section data; model still consistent at 2 sigma leve