Beyond the pill: New medication delivery options for ADHD

Successful treatment of pediatric disorders has necessitated the development of alternative medication formulations, as children may prefer alternative dosage forms to tablets or capsules. This is especially true for attention-deficit/hyperactivity disorder (ADHD), which is one of the most common chronic pediatric conditions and often involves children with a variety of overlapping physical, psychological, or neurodevelopmental disorders. A special challenge for developing alternative dosage forms for ADHD treatment is the incorporation of a once-daily long-acting formulation. Traditional ADHD medication formulations have been limited, and issues surrounding prescribed dosing regimens—including poor medication adherence, difficulty swallowing, and the lack of dosing titration options—persist in ADHD treatment. In other disease areas, the development of alternative formulations has provided options for patients who have issues with consuming solid dosage forms, particularly children and individuals with developmental disorders. In the light of these new developments, several alternative formulations for ADHD medications are under development or have recently become available. This article reviews the various strategies for developing alternative dosage forms in other disease areas and discusses the application of these strategies in ADHD treatment. Alternative dosage forms may increase medication adherence, compliance, and patient preference and, therefore, improve the overall treatment for ADHD.</jats:p

INTRODUCTION

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Chern-Simons Gauge Theory and the AdS(3)/CFT(2) Correspondence

The bulk partition function of pure Chern-Simons theory on a three-manifold is a state in the space of conformal blocks of the dual boundary RCFT, and therefore transforms non-trivially under the boundary modular group. In contrast the bulk partition function of AdS(3) string theory is the modular-invariant partition function of the dual CFT on the boundary. This is a puzzle because AdS(3) string theory formally reduces to pure Chern-Simons theory at long distances. We study this puzzle in the context of massive Chern-Simons theory. We show that the puzzle is resolved in this context by the appearance of a chiral "spectator boson" in the boundary CFT which restores modular invariance. It couples to the conformal metric but not to the gauge field on the boundary. Consequently, we find a generalization of the standard Chern-Simons/RCFT correspondence involving "nonholomorphic conformal blocks" and nonrational boundary CFTs. These generalizations appear in the long-distance limit of AdS(3) string theory, where the role of the spectator boson is played by other degrees of freedom in the theory.Comment: 43 pages, harvma