Origen y evolución de las empresas Multilatinas

The study on the internationalization process of the company has traditionally focused on multinational companies from developed countries, with a minority study in the context of emerging countries. In this paper we analyze the origins and evolution of multinational companies from Latin America, called “Multilatinas”, as well as their special organizational and strategic features, as a consequence of a unique Latin American political, economic, social and cultural context.El estudio sobre el proceso de internacionalización de la empresa tradicionalmente se ha centrado en empresas multinacionales provenientes de países desarrollados, siendo minoritario su estudio en el contexto de países emergentes. En este trabajo analizamos los orígenes y evolución de las empresas multinacionales provenientes de América Latina, denominadas “Multilatinas”, así como los especiales rasgos organizativos y estratégicos de las mismas, fruto de un contexto político, económico, social y cultural único latinoamericano

Pre-ALMA observations of GRBs in the mm/submm range

GRBs generate an afterglow emission that can be detected from radio to X-rays during days, or even weeks after the initial explosion. The peak of this emission crosses the mm/submm range during the first hours to days, making their study in this range crucial for constraining the models. Observations have been limited until now due to the low sensitivity of the observatories in this range. We present observations of 10 GRB afterglows obtained from APEX and SMA, as well as the first detection of a GRB with ALMA, and put them into context with all the observations that have been published until now in the spectral range that will be covered by ALMA. The catalogue of mm/submm observations collected here is the largest to date and is composed of 102 GRBs, of which 88 had afterglow observations, whereas the rest are host galaxy searches. With our programmes, we contributed with data of 11 GRBs and the discovery of 2 submm counterparts. In total, the full sample, including data from the literature, has 22 afterglow detections with redshift ranging from 0.168 to 8.2. GRBs have been detected in mm/submm wavelengths with peak luminosities spanning 2.5 orders of magnitude, the most luminous reaching 10^33erg s^-1 Hz^-1. We observe a correlation between the X-ray brightness at 0.5 days and the mm/submm peak brightness. Finally we give a rough estimate of the distribution of peak flux densities of GRB afterglows, based on the current mm/submm sample. Observations in the mm/submm bands have been shown to be crucial for our understanding of the physics of GRBs, but have until now been limited by the sensitivity of the observatories. With the start of the operations at ALMA, the sensitivity will be increased by more than an order of magnitude. Our estimates predict that, once completed, ALMA will detect up to 98% of the afterglows if observed during the passage of the peak synchrotron emission.Comment: 23 pages, 14 figures, 5 tables (one big one!), Accepted for publication in A&A. Includes the first observation of a GRB afterglow with ALM

Construcción y despliegue de una metodología para el desarrollo de competencias de trabajo en equipo

La creciente importancia en los estudios universitarios de Grado y Máster de las competencias relacionadas con el trabajo en equipo plantea al profesorado la necesidad de adaptar sus metodologías docentes para facilitar el desarrollo de dicha competencia. Este proyecto reúne a un equipo de docentes de diferentes departamentos y facultades, que actualmente imparten asignaturas en las que se exige a los estudiantes trabajar en grupos. El interés del equipo por mejorar su labor docente a la hora de gestionar grupos de trabajo en el aula y fuera de ella motiva el presente proyecto de innovación docente

GRB110715A: Multifrequency study of the first gamma-ray burst observed with ALMA

GRB 110715A had a bright afterglow that was obscured by a high Galactic extinction. We discovered the submillimetre counterpart with APEX and followed it in radio with ATCA for over 2 months. Additional submillimetre observations were performed with ALMA as a test of the ToO procedures during commissioning. UV, optical and NIR observations were performed with UVOT/Swift and GROND at the 2.2 m telescope in La Silla and X-ray data was obtained by XRT/Swift. The dataset is complemented with spectroscopic data from the X-shooter spectrograph at the VLT. From a broadband model we derive a peculiar density profile in the environment of the progenitor, with a discontinuity that produces a break in the light curve at ∼ 1 day after the burst onset. The absorption features present in the intermediate resolution optical/nIR spectra reveal a redshift of 0.8224 and a host galaxy environment with low ionisation and no velocity components beyond 30 km s−1 . These preliminary results will be published elsewhere

β–Lactam TRPM8 Antagonist RGM8-51 Displays Antinociceptive Activity in Different Animal Models

Transient receptor potential melastatin subtype 8 (TRPM8) is a cation channel extensively expressed in sensory neurons and implicated in different painful states. However, the effectiveness of TRPM8 modulators for pain relief is still a matter of discussion, since structurally diverse modulators lead to different results, depending on the animal pain model. In this work, we described the antinociceptive activity of a β–lactam derivative, RGM8-51, showing good TRPM8 antagonist activity, and selectivity against related thermoTRP channels and other pain-mediating receptors. In primary cultures of rat dorsal root ganglion (DRG) neurons, RGM8-51 potently reduced menthol-evoked neuronal firing without affecting the major ion conductances responsible for action potential generation. This compound has in vivo antinociceptive activity in response to cold, in a mouse model of oxaliplatin-induced peripheral neuropathy. In addition, it reduces cold, mechanical and heat hypersensitivity in a rat model of neuropathic pain arising after chronic constriction of the sciatic nerve. Furthermore, RGM8-51 exhibits mechanical hypersensitivity-relieving activity, in a mouse model of NTG-induced hyperesthesia. Taken together, these preclinical results substantiate that this TRPM8 antagonist is a promising pharmacological tool to study TRPM8-related diseases

Mapping the risk of exposure to Crimean-Congo haemorrhagic fever virus in the Iberian Peninsula using Eurasian wild boar (Sus scrofa) as a model

Crimean-Congo haemorrhagic fever (CCHF) virus (CCHFV) is a tick-borne zoonotic pathogen that can cause a lethal haemorrhagic disease in humans. Although the virus appears to be endemically established in the Iberian Peninsula, CCHF is an emerging disease in Spain. Clinical signs of CCHFV infection are mainly manifested in humans, but the virus replicates in several animal species. Understanding the determinants of CCHFV exposure risk from animal models is essential to predicting high-risk exposure hotspots for public health action. With this objective in mind, we designed a cross-sectional study of Eurasian wild boar (Sus scrofa) in Spain and Portugal. The study analysed 5,291 sera collected between 2006 and 2022 from 90 wild boar populations with a specific double-antigen ELISA to estimate CCHFV serum prevalence and identify the main determinants of exposure probability. To do so, we statistically modelled exposure risk with host- and environment-related predictors and spatially projected it at a 10 × 10 km square resolution at the scale of the Iberian Peninsula to map foci of infection risk. Fifty-seven (63.3 %) of the 90 populations had at least one seropositive animal, with seroprevalence ranging from 0.0 to 88.2 %. Anti-CCHFV antibodies were found in 1,026 of 5,291 wild boar (19.4 %; 95 % confidence interval: 18.3–20.5 %), with highest exposure rates in southwestern Iberia. The most relevant predictors of virus exposure risk were wild boar abundance, local rainfall regime, shrub cover, winter air temperature and soil temperature variation. The spatial projection of the best-fit model identified high-risk foci as occurring in most of western and southwestern Iberia and identified recently confirmed risk foci in eastern Spain. The results of the study demonstrate that serological surveys of CCHFV vector hosts are a powerful, robust and highly informative tool for public health authorities to take action to prevent human cases of CCHF in enzootic and emergency settings.This study was funded by the regional Government of Castilla-La Mancha (JCCM) and the EU-European Social Fund (ESF) through project SBPLY/19/180501/000321 and by MCIN/AEI/10.13039/501100011033 and the European Regional Development Fund (EU-ERDF) through project CGL2017–89866-R. We also acknowledge funding by MCIN/AEI/10.13039/501100011033 and by the European Union "Next Generation EU"/PRTR Recovery, Transformation and Resilience Plan-Next Generation EU” through the TED2021–132599B-C21/22 project, by EU-ERDF (POPE 2014–2020) project LifeWATCH INDALO-Scientific Infrastructures for Global Change Monitoring and Adaptation in Andalusia (LIFEWATCH-2019–04-AMA-01) and by “Instituto de Salud Carlos III”, MCIN/AEI/10.13039/501100011033 and EU-Next Generation EU funds through “CIBER-Consorcio Centro de Investigación Biomédica en Red (CB 2021/13/00083)”. SB-F and CH acknowledge funding by JCCM and EU-ESF contracts PREJCCM2019/11 and SUPLY/19/180501/000487, respectively. AP-M was funded by the University of Castilla-La Mancha (UCLM) and EU-ERDF through 2019-PREDUCLM-10932 contract whereas RC-M received funding from MCIN, EU-ERDF and UCLM at PRE2018–083801 contract. DJ-M holds a PhD contract granted by the Own Research Plan of the University of Cordoba and SC-S is supported by an FPU grant from the Spanish Ministry of Universities (FPU19/06,026). This study has been partially funded by the Department of Economic Development and Infrastructures of the Basque Government. AC was supported by a ‘Ramón y Cajal’ post-doctoral grant RYC2021–033084-I funded by MCIN/AEI/10.13039/501,100,011,033 and by European Union NextGenerationEU/PRTR. RM is supported by a postdoctoral contract Margarita Salas Reference MS-23 (University of Extremadura) from the Program of Requalification of the Spanish University System (Spanish Ministry of Universities) financed by the European Union-NextGenerationEU.Peer reviewe

Vegetation and fire dynamics during the last 4000 years in the Cabañeros National Park (central Spain)

The Holocene vegetation dynamics of low- and mid-altitude areas of inland Iberia remain largely unknown, masking possible legacy effects of past land-use on current and future ecosystem trajectories. Here we present a 4000-year long palaeoecological record (pollen, spores, microscopic charcoal) from a mire located in the Cabañeros National Park (Toledo Mountains, central Spain), a region with key conservation challenges due to ongoing land-use changes. We reconstruct late Holocene vegetation history and assess the extent to which climate, land-use and disturbances played a role in the observed changes. Our results show that oak (Quercus) woodlands have been the main forested community of the Toledo Mountains over millennia, with deciduous Quercus pyrenaica and Quercus faginea more abundant than evergreen Quercus ilex and Quercus suber, particularly on the humid soils of the valley bottoms. Deciduous oak woodlands spread during drier periods replacing hygrophilous communities (Betula, Salix, hygrophilous Ericaceae) on the edges of the mire, and could cope with fire disturbance variability under dry conditions (e.g. ca. 3800–3000–1850–1050 BC- and 1300–100 cal BP–AD 650–1850-) as suggested by regional palaeoclimatic reconstructions. Pollen and coprophilous fungi data suggest that enhanced fire occurrence at ca. 1300–100 cal BP (AD 650–1850) was due to deliberate burning by local people to promote pastoral and arable farming at the expense of woodlands/shrublands under dry conditions. While historical archives date the onset of strong human impact on the vegetation of Cabañeros to the period at and after the Ecclesiastical Confiscation (ca. 150–100 cal BP, AD 1800–1850), our palaeoecological data reveal that land-use was already intense during the Arab period (ca. 1250–900 cal BP, AD 700–1050) and particularly marked during the subsequent City of Toledo's rule (ca. 700–150 cal BP, AD 1250–1800). Finally, we hypothesize that persistent groundwater discharge allowed the mires of the Toledo Mountains to act as interglacial hydrologic microrefugia for some hygrophilous woody plants (Betula, Myrica gale, Erica tetralix) during pronounced dry spells over the past millennia