54 research outputs found
Role of Calcitonin Gene-Related Peptide in Bone Repair after Cyclic Fatigue Loading
Calcitonin gene related peptide (CGRP) is a neuropeptide that is abundant in the sensory neurons which innervate bone. The effects of CGRP on isolated bone cells have been widely studied, and CGRP is currently considered to be an osteoanabolic peptide that has effects on both osteoclasts and osteoblasts. However, relatively little is known about the physiological role of CGRP in-vivo in the skeletal responses to bone loading, particularly fatigue loading.We used the rat ulna end-loading model to induce fatigue damage in the ulna unilaterally during cyclic loading. We postulated that CGRP would influence skeletal responses to cyclic fatigue loading. Rats were fatigue loaded and groups of rats were infused systemically with 0.9% saline, CGRP, or the receptor antagonist, CGRP(8-37), for a 10 day study period. Ten days after fatigue loading, bone and serum CGRP concentrations, serum tartrate-resistant acid phosphatase 5b (TRAP5b) concentrations, and fatigue-induced skeletal responses were quantified. We found that cyclic fatigue loading led to increased CGRP concentrations in both loaded and contralateral ulnae. Administration of CGRP(8-37) was associated with increased targeted remodeling in the fatigue-loaded ulna. Administration of CGRP or CGRP(8-37) both increased reparative bone formation over the study period. Plasma concentration of TRAP5b was not significantly influenced by either CGRP or CGRP(8-37) administration.CGRP signaling modulates targeted remodeling of microdamage and reparative new bone formation after bone fatigue, and may be part of a neuronal signaling pathway which has regulatory effects on load-induced repair responses within the skeleton
Relationship between body mass index and perceived insufficient sleep among U.S. adults: an analysis of 2008 BRFSS data
[L’effet de l’affinité pour l’oxygène et du poids moléculaire des TOBH sur l’oxygé-nation et la tension artérielle chez les rats]
Ambulatory Office Visits and Medical Comorbidities Associated with Obstructive Sleep Apnea
Higher Baseline BMI is Associated with Greater Reduction of Apnea-Hypopnea Index After Bariatric Surgery
Intimal hyperplasia: The permeation of serum-derived substance into the arterial autovein graft under abnormal blood flow
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