Educational Psychology in the Virtual World: A Small Study on Practice Adaptations During the COVID-19 Pandemic and Potential Benefits for Future Services

Educational psychologists (EPs) have made significant adaptations to their practice during the COVID-19 pandemic due to educational and practice restrictions in England. These adaptations, whilst facing many challenges, have also presented opportunities for growth within the profession. The current study gained a small group of EPs’ views of their experiences of working remotely through the completion of an online questionnaire. Subsequent data analysis found that EPs increased their confidence working remotely and using technology during the pandemic. The main changes reported by the participating EPs related to how they accessed clients and adapted their practice to suit remote working. Personal and professional successes were identified, and many EPs indicated it would be useful to continue some elements of remote working following the pandemic. An important area for future exploration would be to further investigate the benefits of remote working and gain the views of other stakeholders regarding their experiences of remote EP practice

ITS 1.5 Reference Manual

This reference manual consists of two parts. The first (sections 1 through 6) is intended for those who are either interested in the ITS 1.5 time sharing monitor for its own sake or who wish to write machine language programs to run under it. Some knowledge of PDP-6 (or PDP-10) machine language is useful in reading this part. The second part (sections 7, 8, and 9) describes three programs that run under ITS. The first program (DDT) is a modified machine language debugging program that also replaces the "monitor command" level (where the user is typing directly at the monitor) present in most time-sharing systems. The remaining two (PEEK and LOCK) are a status display and a miscellaneous utility program. It should be remembered that the McCulloch Laboratory PDP-6 and PDP-10 installation is undergoing continuous software and hardware development which may rapidly outdate this manual

Applying real-world data from expanded-access (“compassionate use”) patients to drug development

Our drug development process has produced many life-saving medications, but patients experiencing rare diseases and similar conditions often are left with limited options for treatment. For an approved treatment to be developed, research on a new candidate or existing drug must validate safety and efficacy based on contemporary research expectations. Randomized clinical trials are conducted for this purpose, but they are also costly, laborious, and time-consuming. For this reason, The 21st Century Cures Act mandates that the US Food and Drug Administration look for alternative methods for approving drugs, in particular exploring the uses of real-world data and evidence. Expanded access (“compassionate use”) is a pathway for the clinical treatment of patients using drugs that are not yet approved for prescribing in the United States. Using real-world evidence generated from expanded-access patients presents an opportunity to provide critical data on patient outcomes that can serve regulatory approval in conjunction with other observational datasets or clinical trials, and in limited circumstances may be the best data available for regulatory review. In doing so, we may also support and encourage patient-centered care and a personalized medicine approach to drug development

Coriolis Effect on Dynamic Stall in a Vertical Axis Wind Turbine at Moderate Reynolds Number

The immersed boundary method is used to simulate the flow around a two-dimensional rotating NACA 0018 airfoil at sub-scale Reynolds number in order to investigate the separated flow occurring on a vertical-axis wind turbine. The influence of dynamic stall on the forces is characterized as a function of tip-speed ratio. The influence of the Coriolis effect is also investigated by comparing the rotating airfoil to one undergoing a equivalent planar motion, which is composed of surging and pitching motions that produce an equivalent speed and angle-of-attack variation over the cycle. When the angle of attack of a rotating airfoil starts to decrease in the upwind half cycle, the Coriolis force leads to a wake-capturing phenomenon of a vortex pair at low tip-speed ratio. This effects occurs at a slightly different phase in each cycle and leads to a significant decrease in the average lift during the downstroke phase. Moreover, the wake-capturing is only observed when the combination of surging, pitching, and Coriolis force are present. Finally, an actuator model is placed at an appropriate location on the suction side of the airfoil surface to control the wake-capturing phenomenon. Based on preliminary simulations, a momentum coefficient above 0.02 was able to increase the average lift by more than 70% over the upwind-half cycle

Valence state of Mn in Ca-doped LaMnO3 studied by high-resolution Mn K ß emission spectroscopy

Mn K ß x-ray emission spectra provide a direct method to probe the effective spin state and charge density on the Mn atom and is used in an experimental study of a class of Mn oxides. Specifically, the Mn K ß line positions and detailed spectral shapes depend on the oxidation and the spin state of the Mn sites as well as the degree of d covalency/itinerancy. Theoretical calculations including atomic charge and multiplet effects, as well as crystal-field splittings and covalency effects, are used as a guide to the experimental results. Direct comparison of the ionic system MnF2 and the covalent system MnO reveals significant changes due to the degree of covalency of Mn within atomic-type Mn K ß simulations. Moreover, comparisons of measurement with calculations support the assumed high spin state of Mn in all of the systems studied. The detailed shape and energy shift of the spectra for the perovskite compounds, LaMnO3 and CaMnO3, are, respectively, found to be very similar to the covalent Mn^(3+)-Mn2O3 and Mn^(4+)-MnO2 compounds thereby supporting the identical Mn-state assignments. Comparison to the theoretical modeling emphasizes the strong covalency in these materials. Detailed Mn K b x-ray emission results on the La1_xCaxMnO3 system can be well fit by linear superpositions of the end member spectra, consistent with a mixed-valent character for the intermediate compositions. However, an arrested Mn-valence response to the doping in the x<0.3 range is found. No evidence for Mn^2+ is observed at any x values seemingly ruling out proposals regarding Mn^3+ disproportionation

Mcl-1 is a key regulator of the ovarian reserve

A majority of ovarian follicles are lost to natural death, but the disruption of factors involved in maintenance of the oocyte pool results in a further untimely follicular depletion known as premature ovarian failure. The anti-apoptotic B-cell lymphoma 2 (Bcl-2) family member myeloid cell leukemia-1 (MCL-1) has a pro-survival role in various cell types; however, its contribution to oocyte survival is unconfirmed. We present a phenotypic characterization of oocytes deficient in Mcl-1, and establish its role in maintenance of the primordial follicle (PMF) pool, growing oocyte survival and oocyte quality. Mcl-1 depletion resulted in the premature exhaustion of the ovarian reserve, characterized by early PMF loss because of activation of apoptosis. The increasingly diminished surviving cohort of growing oocytes displayed elevated markers of autophagy and mitochondrial dysfunction. Mcl-1-deficient ovulated oocytes demonstrated an increased susceptibility to cellular fragmentation with activation of the apoptotic cascade. Concomitant deletion of the pro-apoptotic Bcl-2 member Bcl-2-associated X protein (Bax) rescued the PMF phenotype and ovulated oocyte death, but did not prevent the mitochondrial dysfunction associated with Mcl-1 deficiency and could not rescue long-term breeding performance. We thus recognize MCL-1 as the essential survival factor required for conservation of the postnatal PMF pool, growing follicle survival and effective oocyte mitochondrial function

Withdrawal-induced delirium associated with a benzodiazepine switch: a case report

<p>Abstract</p> <p>Introduction</p> <p>Introduced in the early 1960s, diazepam remains among the most frequently prescribed benzodiazepine-type sedatives and hypnotics. Patients with chronic use of short-acting benzodiazepines are frequently switched to diazepam because the accumulating, long-acting metabolite, N-desmethyl-diazepam, prevents benzodiazepine-associated withdrawal symptoms, which can occur during trough plasma levels of short-acting benzodiazepines. Although mild to moderate withdrawal symptoms are frequently observed during benzodiazepine switching to diazepam, severe medical complications associated with this treatment approach have thus far not been reported.</p> <p>Case presentation</p> <p>A 64-year-old female Caucasian with major depression, alcohol dependence and benzodiazepine dependence was successfully treated for depression and, after lorazepam-assisted alcohol detoxification, was switched from lorazepam to diazepam to facilitate benzodiazepine discontinuation. Subsequent to the benzodiazepine switch, our patient unexpectedly developed an acute delirious state, which quickly remitted after re-administration of lorazepam. A newly diagnosed early form of mixed dementia, combining both vascular and Alzheimer-type lesions, was found as a likely contributing factor for the observed vulnerability to benzodiazepine-induced withdrawal symptoms.</p> <p>Conclusion</p> <p>Chronic use of benzodiazepines is common in the elderly and a switch to diazepam often precedes benzodiazepine discontinuation trials. However, contrary to common clinical practice, benzodiazepine switching to diazepam may require cross-titration with slow tapering of the first benzodiazepine to allow for the build-up of N-desmethyl-diazepam, in order to safely prevent severe withdrawal symptoms. Alternatively, long-term treatment with low doses of benzodiazepines may be considered, especially in elderly patients with chronic use of benzodiazepines and proven vulnerability to benzodiazepine-associated withdrawal symptoms.</p

Dynamic separation on a pitching and surging airfoil as a model for flow over vertical axis wind turbine blades

Vertical axis wind turbine (VAWT) blades undergo dynamic separation due to the large angle of attack variation they experience during a turbine rotation. The flow over a single blade was modeled using a sinusoidally pitching and surging airfoil in a constant free stream flow at a mean chord Reynolds number of 10^5. Two-dimensional, time resolved velocity fields were acquired using particle image velocimetry (PIV). Vorticity contours were used to visualize shear layer and vortex activity. A low order model of dynamic separation was developed using Dynamic Mode Decomposition (DMD). A primary and secondary dynamic separation mode were identified as the critical drivers for the unsteady flow field

Lifeworld Inc. : and what to do about it

Can we detect changes in the way that the world turns up as they turn up? This paper makes such an attempt. The first part of the paper argues that a wide-ranging change is occurring in the ontological preconditions of Euro-American cultures, based in reworking what and how an event is produced. Driven by the security – entertainment complex, the aim is to mass produce phenomenological encounter: Lifeworld Inc as I call it. Swimming in a sea of data, such an aim requires the construction of just enough authenticity over and over again. In the second part of the paper, I go on to argue that this new world requires a different kind of social science, one that is experimental in its orientation—just as Lifeworld Inc is—but with a mission to provoke awareness in untoward ways in order to produce new means of association. Only thus, or so I argue, can social science add to the world we are now beginning to live in