Research to Practice: Leveraging Concept Inventories in Statics Instruction

There are many common challenges with classroom assessment, especially in first-year large enrollment courses, including managing high quality assessment within time constraints, and promoting effective study strategies. This paper presents two studies: 1) using the CATS instrument to validate multiple-choice format exams for classroom assessment, and 2) using the CATS instrument as a measure of metacognitive growth over time. The first study focused on validation of instructor generated multiple choice exams because they are easier to administer, grade, and return for timely feedback, especially for large enrollment classes. The limitation of multiple choice exams, however, is that it is very difficult to construct questions to measure higher order content knowledge beyond recalling facts. A correlational study was used to compare multiple choice exam scores with relevant portions of the CATS assessment (taken within a week of one another). The results indicated a strong relationship between student performance on the CATS assessment and instructor generated exams, which infers that both assessments were measuring similar content areas. The second study focused on a metacognition, more specifically, on students’ ability to self-assess the extent of their own knowledge. In this study students were asked to rank their confidence for each CATS item on a 1 (not at all confident) to 4 (very confident) Likert-type scale. With the 4-point scale, there was no neutral option provided; students were forced to identify some degree of confident or not confident. A regression analysis was used to compare the relationship between performance and confidence for pre, post, and delayed-post assessments. Results suggested that the students’ self-knowledge of their performance improved over time

Visualizing Multivariate Hierarchic Data Using Enhanced Radial Space-Filling Layout

Currently, visualization tools for large ontologies (e.g., pathway and gene ontologies) result in a very flat wide tree that is difficult to fit on a single display. This paper develops the concept of using an enhanced radial space-filling (ERSF) layout to show biological ontologies efficiently. The ERSF technique represents ontology terms as circular regions in 3D. Orbital connections in a third dimension correspond to non-tree edges in the ontology that exist when an ontology term belongs to multiple categories. Biologists can use the ERSF layout to identify highly activated pathway or gene ontology categories by mapping experimental statistics such as coefficient of variation and overrepresentation values onto the visualization. This paper illustrates the use of the ERSF layout to explore pathway and gene ontologies using a gene expression dataset from E. coli

Organizational and Leadership Implications for Transformational Development

Transformational development is a concept of change that originated in the Christian context but has now become generally used in the work of both secular and faith-based organizations. The growing use of the concept by organizations that are fundamentally different has naturally led to some confusion about what the concept means and what it takes to effectively implement it. In this article, we describe the key features of the concept and how they are important in determining the organizational requirements for its effective implementation. Drawing on a few cases, the paper highlights the centrality of faith in transformational development work

Quantum-critical dynamics of the Skyrmion lattice

Near to filling fraction nu=1, the quantum Hall ferromagnet contains multiple Skyrmion spin excitations. This multi-Skyrmion system has a tremendously rich quantum-critical structure. This is simplified when Skyrmions are pinned by disorder. We calculate the nuclear relaxation rate in this case and compare the result with experiment. We discuss how such measurements may be used to further probe the quantum-critical structure of the multi-Skyrmion system

Plasticity in bilateral superior temporal cortex: effects of deafness and cochlear implantation on auditory and visual speech processing

While many individuals can benefit substantially from cochlear implantation, the ability to perceive and understand auditory speech with a cochlear implant (CI) remains highly variable amongst adult recipients. Importantly, auditory performance with a CI cannot be reliably predicted based solely on routinely obtained information regarding clinical characteristics of the CI candidate. This review argues that central factors, notably cortical function and plasticity, should also be considered as important contributors to the observed individual variability in CI outcome. Superior temporal cortex (STC), including auditory association areas, plays a crucial role in the processing of auditory and visual speech information. The current review considers evidence of cortical plasticity within bilateral STC, and how these effects may explain variability in CI outcome. Furthermore, evidence of audio-visual interactions in temporal and occipital cortices is examined, and relation to CI outcome is discussed. To date, longitudinal examination of changes in cortical function and plasticity over the period of rehabilitation with a CI has been restricted by methodological challenges. The application of functional near-infrared spectroscopy (fNIRS) in studying cortical function in CI users is becoming increasingly recognised as a potential solution to these problems. Here we suggest that fNIRS offers a powerful neuroimaging tool to elucidate the relationship between audio-visual interactions, cortical plasticity during deafness and following cochlear implantation, and individual variability in auditory performance with a CI

Regulation of phosphorylase kinase by low concentrations of Ca ions upon muscle contraction: the connection between metabolism and muscle contraction and the connection between muscle physiology and Ca-dependent signal transduction

It had long been one of the crucial questions in muscle physiology how glycogenolysis is regulated in connection with muscle contraction, when we found the answer to this question in the last half of the 1960s. By that time, the two principal currents of muscle physiology, namely, the metabolic flow starting from glycogen and the mechanisms of muscle contraction, had already been clarified at the molecular level thanks to our senior researchers. Thus, the final question we had to answer was how to connect these two currents. We found that low concentrations of Ca ions (10−7–10−4 M) released from the sarcoplasmic reticulum for the regulation of muscle contraction simultaneously reversibly activate phosphorylase kinase, the enzyme regulating glycogenolysis. Moreover, we found that adenosine 3′,5′-monophosphate (cyclic AMP), which is already known to activate muscle phosphorylase kinase, is not effective in the absence of such concentrations of Ca ions. Thus, cyclic AMP is not effective by itself alone and only modifies the activation process in the presence of Ca ions (at that time, cyclic AMP-dependent protein kinase had not yet been identified). After a while, it turned out that our works have not only provided the solution to the above problem on muscle physiology, but have also been considered as the first report of Ca-dependent protein phosphorylation, which is one of the central problems in current cell biology. Phosphorylase kinase is the first protein kinase to phosphorylate a protein resulting in the change in the function of the phosphorylated protein, as shown by Krebs and Fischer. Our works further showed that this protein kinase is regulated in a Ca-dependent manner. Accordingly, our works introduced the concept of low concentrations of Ca ions, which were first identified as the regulatory substance of muscle contraction, to the vast field of Ca biology including signal transduction

The impact of the metabotropic glutamate receptor and other gene family interaction networks on autism

Although multiple reports show that defective genetic networks underlie the aetiology of autism, few have translated into pharmacotherapeutic opportunities. Since drugs compete with endogenous small molecules for protein binding, many successful drugs target large gene families with multiple drug binding sites. Here we search for defective gene family interaction networks (GFINs) in 6,742 patients with the ASDs relative to 12,544 neurologically normal controls, to find potentially druggable genetic targets. We find significant enrichment of structural defects (P≤2.40E-09, 1.8-fold enrichment) in the metabotropic glutamate receptor (GRM) GFIN, previously observed to impact attention deficit hyperactivity disorder (ADHD) and schizophrenia. Also, the MXD-MYC-MAX network of genes, previously implicated in cancer, is significantly enriched (P≤3.83E-23, 2.5-fold enrichment), as is the calmodulin 1 (CALM1) gene interaction network (P≤4.16E-04, 14.4-fold enrichment), which regulates voltage-independent calcium-activated action potentials at the neuronal synapse. We find that multiple defective gene family interactions underlie autism, presenting new translational opportunities to explore for therapeutic interventions

Running the club for love: Challenges for identity, accountability and governance relationships

The current context of State sport governance and funding structures in the United Kingdom continue to challenge national, regional and local bodies and community clubs’ abilities to fulfil ambitions to support participation and competition at all levels. Notwithstanding sport clubs’ laudable intentions to support involvement and encourage participation (often with limited resources, guidance and communication from National Governing Bodies (NGB)), clubs face considerable practical, political and ideological constraints that adversely affect their day-to-day operations and ability to translate sport policy in ‘action’ in meaningful ways. Drawing on data from 21 athletic clubs in England, this paper examines how athletic clubs’ relations with the NGB, UK Athletics (UKA), raise questions about the clubs’ individual and collective identities, agendas, ideals and overall value to its members