24 research outputs found
Assessment of coronary endothelial function using blood oxygenation level dependant cardiovascular magnetic resonance imaging (BOLD-CMR) in a canine model
2132 Assessment of myocardial oxygenation in the canine heart using blood oxygen level-dependent magnetic resonance imaging
1078 T1-weighted, navigator-gated HASTE for the monitoring of the early enhancement of myocardium
1142 A new approach towards improved visualization of myocardial edema using T2-weighted imaging
Characterization of myocardial T1 and partition coefficient as a function of time after gadolinium delivery in healthy subjects
Is hemorrhage in acute reperfused myocardial infarction a new marker for the severity of tissue injury?
Assessment of coronary endothelial function using blood oxygenation level dependant cardiovascular magnetic resonance imaging (BOLD-CMR) in a canine model
Oxygenation-sensitive CMR for assessing vasodilator-induced changes of myocardial oxygenation
<p>Abstract</p> <p>Background</p> <p>As myocardial oxygenation may serve as a marker for ischemia and microvascular dysfunction, it could be clinically useful to have a non-invasive measure of changes in myocardial oxygenation. However, the impact of induced blood flow changes on oxygenation is not well understood. We used oxygenation-sensitive CMR to assess the relations between myocardial oxygenation and coronary sinus blood oxygen saturation (SvO<sub>2</sub>) and coronary blood flow in a dog model in which hyperemia was induced by intracoronary administration of vasodilators.</p> <p>Results</p> <p>During administration of acetylcholine and adenosine, CMR signal intensity correlated linearly with simultaneously measured SvO<sub>2 </sub>(<it>r</it><sup>2 </sup>= 0.74, <it>P </it>< 0.001). Both SvO<sub>2 </sub>and CMR signal intensity were exponentially related to coronary blood flow, with SvO2 approaching 87%.</p> <p>Conclusions</p> <p>Myocardial oxygenation as assessed with oxygenation-sensitive CMR imaging is linearly related to SvO<sub>2 </sub>and is exponentially related to vasodilator-induced increases of blood flow. Oxygenation-sensitive CMR may be useful to assess ischemia and microvascular function in patients. Its clinical utility should be evaluated.</p