Păstorul Martir: Liviu Galaction Munteanu (1898-1961). Preocupările biblice și relevanța lor în cadrul teologiei pastorale românești

After the establishment of the communist regime in Romania, between State and Church held a deaf war and personality of priest professor Dr. Liviu Galaction Munteanu was essential in terms of counteraction the Marxist-Leninist ideology. As an officiating priest and refined theologian, "time and timeless" (2 Tim. 4, 2), father professor was an testimony by word and deed, always remaining believers that they shepherded and students, by the great role that is keeping the Orthodox faith: "Theology must be aware of the great role they should play in people`s life". He emphasised the importance of theological training of priest as witnesses, in an age in which the Church should be more present among people, to the "œroller" totalitarian communist, aiming at creating "œnew man" through propaganda scientific-materialistic, atheistic. In this context, the only solution was establishment of a program of catechesis, working through priests in every parish. Catechesis has not been done, Father intention being considered "œhostile" by the state bodies. His entire life was dedicated word, that ministered to Christ, the divine Logos incarnate. By his exhortations clergy aware of the importance of the mission given to each priest an solidarity with the faithful. His actions also presents itself as a real priest who was aware of his mission responsibility

The Serine/Threonine Protein Kinase (Akt)/ Protein Kinase B (PkB) Signaling Pathway in Breast Cancer

According to statistical data published in 2019, breast cancer is among the leading causes of death in women worldwide. The serine/threonine kinase (AKT) or protein kinase B (PkB) signaling pathway is activated by phosphorylation processes, which further is associated with cell growth, proliferation, and survival, but also with activation of glucose metabolism. Mutations of the AKT signaling pathway components (especially PI3KCA and PTEN) have been observed in breast cancer patients, which are associated with resistance to hormonal treatment. Many clinical trials are testing the effect of AKT inhibition in order to block the growth and proliferation of breast cancer cells. The purpose of this review is to present the incidence of this neoplastic disease, to describe AKT signaling pathways activation, mutations that occur at its level, and inhibitors that can block this protein kinase

The Serine/Threonine Protein Kinase (Akt)/ Protein Kinase B (PkB) Signaling Pathway in Breast Cancer

According to statistical data published in 2019, breast cancer is among the leading causes of death in women worldwide. The serine/threonine kinase (AKT) or protein kinase B (PkB) signaling pathway is activated by phosphorylation processes, which further is associated with cell growth, proliferation, and survival, but also with activation of glucose metabolism. Mutations of the AKT signaling pathway components (especially PI3KCA and PTEN) have been observed in breast cancer patients, which are associated with resistance to hormonal treatment. Many clinical trials are testing the effect of AKT inhibition in order to block the growth and proliferation of breast cancer cells. The purpose of this review is to present the incidence of this neoplastic disease, to describe AKT signaling pathways activation, mutations that occur at its level, and inhibitors that can block this protein kinase

ADIPOSE TISSUE BIOMARKERS AND SYSTEMIC HEALTH

Adipose tissue consists primarily of adipocytes, being responsible for storing the body's energy reserves. Adipokines secreted by adipose tissue play important roles in the human body. The purpose of this review is to present the most important adipokines and their involvement in the physiological processes but also in the pathogenesis of numerous systemic diseases commonly associated with obesity

HYPERLEPTINEMIA AND CARDIOVASCULAR SYSTEM

Leptin is the satiety hormone, synthesized in the adipose tissue that reduces food intake, being involved in glucose and lipid metabolism. Hyperleptinemia correlates with obesity and represents a risk factor in the pathology of the cardiovascular system. Increased concentrations of leptin have been observed in patients with hypertension or atherosclerosis. In vitro studies suggest the angiogenic role of leptin. The purpose of this review is to present the metabolic effects of hyperleptinemia in the cardiovascular system

OBESITY INDUCES DNA DAMAGE

A diet rich in saturated lipids, refined carbohydrates associated with a sedentary lifestyle leads to obesity in both adults and children. Obesity is associated with the existence of a chronic inflammatory process, that will further lead to systemic oxidative stress and DNA oxidative damage. There is currently a positive correlation between obesity and cancer due to nuclear but also mitochondrial DNA injury. Obesity is a risk factor for the development of several types of cancer such as breast, prostate or colorectal. The purpose of this review is to present the effects of obesity on human body, by describing the chronic inflammatory process, oxidative stress, and the molecular mechanisms involved in cancer progression

Mineralogical and Microstructural Characteristics of Two Dental Pulp Capping Materials

This paper aims to investigate the composition, surface, and microstructural characteristics, and bioactivity of two commercially available pulp capping materials known as TheraCal LC and BIO MTA+. The materials were prepared as cylindrical samples and assessed by X-ray diffraction (XRD) and complex thermal analysis for mineralogical characterization, and by scanning electron microscopy (SEM) coupled with energy dispersive of X-ray (EDX), Fourier-Transformed Infrared Spectroscopy (FT-IR), and atomic force microscopy (AFM) for microstructural and surface characteristics. The in vitro bioactivity was highlighted by surface mineralization throughout SEM coupled with EDX and FT-IR analysis. XRD analysis performed on both materials showed calcium silicate phases and different radiopacifying compounds. AFM measurements indicated a smoother and more homogenous surface with a lower average roughness for TheraCal LC due to the resin matrix from its composition. FT-IR analysis displayed bands for several compounds in both materials. Both materials exhibited bioactive properties showing surface mineralization after being immersed in solution similar to the human physiological environment. However, the MTA cement showed a better mineralization due to the anhydrous and hydrated phases