Distance learning material for adult education: The case of the Open University of Cyprus

The paper analyses distance learning material used in the 'Continuing Education & Lifelong Learning' (CELL) and the 'Applied Educational Research' (AER) module of the Masters in Education at the Open University of Cyprus with the aim to unveil the sort of pedagogical practices promoted within the two modules. To this end, the Bernsteinian concept of framing, involving instructional rules was used. Results of the analysis reveal that the CELL module is largely oriented towards definite arrangement of instructional rules, by introducing strong framing in the educational process, while the AER module establishes a generally weak framing. Moreover, the findings disclose tensions between the principles of distance and adult education, with the former implying explicit and rather 'close' direction of study, and the latter advocating flexibility in adult learning. © Common Ground, Vasilia Christidou, Maria N. Gravani, Vassilia Hatzinikita, All Rights Reserved

The effect of TRV027 on coagulation in COVID 19: A pilot randomized, placebo-controlled controlled trial.

COVID-19 causes significant thrombosis and coagulopathy, with elevated D-dimer a predictor of adverse outcome. The precise mechanism of this coagulopathy remains unclear, one hypothesis is that loss of Angiotensin Converting Enzyme 2 activity during viral endocytosis leads to pro-inflammatory angiotensin II accumulation, loss of angiotensin-1-7 and subsequent vascular endothelial activation. We undertook a double blind randomised, placebo controlled experimental medicine study to assess the effect of TRV027, a synthetic angiotensin-1-7 analogue on D-dimer in 30 patients admitted to hospital with COVID-19 (REC ref. 20/HRA/3414), Clinical Trial No. NCT04419610. The study showed a similar rate of adverse events in TRV027 and control groups. There was a numerical decrease in D-dimer in the TRV027 group and increase in D-dimer in the placebo group, however, this did not reach statistical significance (p=0.15). A Bayesian analysis demonstrated there was a 92% probability that this change represented a true drug effect

The effect of TRV027 on coagulation in COVID 19: A pilot randomized, placebo-controlled controlled trial

COVID-19 causes significant thrombosis and coagulopathy, with elevated D-dimer a predictor of adverse outcome. The precise mechanism of this coagulopathy remains unclear, one hypothesis is that loss of Angiotensin Converting Enzyme 2 activity during viral endocytosis leads to pro-inflammatory angiotensin II accumulation, loss of angiotensin-1-7 and subsequent vascular endothelial activation. We undertook a double blind randomised, placebo controlled experimental medicine study to assess the effect of TRV027, a synthetic angiotensin-1-7 analogue on D-dimer in 30 patients admitted to hospital with COVID-19 (REC ref. 20/HRA/3414), Clinical Trial No. NCT04419610. The study showed a similar rate of adverse events in TRV027 and control groups. There was a numerical decrease in D-dimer in the TRV027 group and increase in D-dimer in the placebo group, however, this did not reach statistical significance (p=0.15). A Bayesian analysis demonstrated there was a 92% probability that this change represented a true drug effect