Target-Normal Single Spin Asymmetries Measured with Positrons

Two-photon exchange and the larger class of hadronic box diagrams are difficult to calculate without a large degree of model-dependence. At the same time, these processes are significant radiative corrections in parity-violating electron scattering, in neutron decay, and may even be responsible for the proton's form factor ratio discrepancy. New kinds of experimental data are needed to help constrain models and guide future box-diagram calculations. The target-normal single spin asymmetry, $A_n$, formed with an unpolarized beam scattering from a target that is polarized normal to the scattering plane, is sensitive to the imaginary part of the two-photon exchange amplitude, and can provide a valuable constraint. A measurement with both electrons and positrons can reduce sources of experimental error, and distinguish between the effects of two-photon exchange and those of time-reversal symmetry violation. This article describes a proposed experiment in Hall A, using the new Super Big-Bite Spectrometer that can cover a momentum transfer range in the critical zone of uncertainty between where hadronic calculations and those based on partonic degrees of freedom are expected to be accurate.Comment: 7 pages, 4 figures. arXiv admin note: substantial text overlap with arXiv:2007.1508

A Direct Measurement of Hard Two-Photon Exchange with Electrons and Positrons at CLAS12

One of the most surprising discoveries made at Jefferson Lab has been the discrepancy in the determinations of the proton's form factor ratio $\mu_p G_E^p/G_M^p$ between unpolarized cross section measurements and the polarization transfer technique. Over two decades later, the discrepancy not only persists but has been confirmed at higher momentum transfers now accessible in the 12-GeV era. The leading hypothesis for the cause of this discrepancy, a non-negligible contribution from hard two-photon exchange, has neither been conclusively proven or disproven. This state of uncertainty not only clouds our knowledge of one-dimensional nucleon structure but also poses a major concern for our field's efforts to map out the three-dimensional nuclear structure. A better understanding of multi-photon exchange over a wide phase space is needed. We propose making comprehensive measurements of two-photon exchange over a wide range in momentum transfer and scattering angle using the CLAS12 detector. Specifically, we will measure the ratio of positron-proton to electron-proton elastic scattering cross sections, using the proposed positron beam upgrade for CEBAF. The experiment will use 2.2, 4.4, and 6.6 GeV lepton beams incident on the standard CLAS12 unpolarized hydrogen target. Data will be collected by the CLAS12 detector in its standard configuration, except for a modified trigger to allow the recording of events with beam leptons scattered into the CLAS12 central detector. The sign of the beam charge, as well as the polarity of the CLAS12 solenoid and toroid, will be reversed several times in order to suppress systematics associated with local detector efficiency and time-dependent detector performance. The proposed high-precision determination of two-photon effects will be...Comment: Experimental Proposal E12+23-008 submitted to Jefferson Lab PAC 51, 34 pages, 18 figure

The Two-Photon Exchange Experiment at DESY

We propose a new measurement of the ratio of positron-proton to electron-proton elastic scattering at DESY. The purpose is to determine the contributions beyond single-photon exchange, which are essential for the Quantum Electrodynamic (QED) description of the most fundamental process in hadronic physics. By utilizing a 20 cm long liquid hydrogen target in conjunction with the extracted beam from the DESY synchrotron, we can achieve an average luminosity of $2.12\times10^{35}$ cm$^{-2}\cdot$s$^{-1}\cdot$sr$^{-1}$ ($\approx200$ times the luminosity achieved by OLYMPUS). The proposed TPEX experiment entails a commissioning run at 2 GeV, followed by measurements at 3 GeV, thereby providing new data up to $Q^2=4.6$ (GeV/$c$)$^2$ (twice the range of current measurements). We present and discuss the proposed experimental setup, run plan, and expectations.Comment: 10 pages, 14 figures. arXiv admin note: substantial text overlap with arXiv:2301.0470

Species-Specific Expansion and Molecular Evolution of the 3-hydroxy-3-methylglutaryl Coenzyme A Reductase (HMGR) Gene Family in Plants

Kazakh dandelion (Taraxacum kok-saghyz, Tk) is a rubber-producing plant currently being investigated as a source of natural rubber for industrial applications. Like many other isoprenoids, rubber is a downstream product of the mevalonate pathway. The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) enzyme catalyzes the conversion of 3-hydroxy-3-methylglutaryl-CoA to mevalonic acid, a key regulatory step in the MVA pathway. Such regulated steps provide targets for increases in isoprenoid and rubber contents via genetic engineering to increase enzyme activities. In this study, we identify a TkHMGR1 gene that is highly expressed in the roots of Kazakh dandelion, the main tissue where rubber is synthesized and stored. This finding paves the way for further molecular and genetic studies of the TkHMGR1 gene, and its role in rubber biosynthesis in Tk and other rubber-producing plants

International Consensus Statement on Rhinology and Allergy: Rhinosinusitis

Background: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICAR‐RS‐2021 as well as updates to the original 140 topics. This executive summary consolidates the evidence‐based findings of the document. Methods: ICAR‐RS presents over 180 topics in the forms of evidence‐based reviews with recommendations (EBRRs), evidence‐based reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary. Results: ICAR‐RS‐2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidence‐based management algorithm is provided. Conclusion: This ICAR‐RS‐2021 executive summary provides a compilation of the evidence‐based recommendations for medical and surgical treatment of the most common forms of RS