Corrigendum to "Cullen numbers with the Lehmer Property"

In this note, we correct an oversight from the paper mentioned in the title

Iterative design of dynamic experiments in modeling for optimization of innovative bioprocesses

Finding optimal operating conditions fast with a scarce budget of experimental runs is a key problem to speed up the development and scaling up of innovative bioprocesses. In this paper, a novel iterative methodology for the model-based design of dynamic experiments in modeling for optimization is developed and successfully applied to the optimization of a fed-batch bioreactor related to the production of r-interleukin-11 (rIL-11) whose DNA sequence has been cloned in an Escherichia coli strain. At each iteration, the proposed methodology resorts to a library of tendency models to increasingly bias bioreactor operating conditions towards an optimum. By selecting the ‘most informative’ tendency model in the sequel, the next dynamic experiment is defined by re-optimizing the input policy and calculating optimal sampling times. Model selection is based on minimizing an error measure which distinguishes between parametric and structural uncertainty to selectively bias data gathering towards improved operating conditions. The parametric uncertainty of tendency models is iteratively reduced using Global Sensitivity Analysis (GSA) to pinpoint which parameters are keys for estimating the objective function. Results obtained after just a few iterations are very promising.Fil: Cristaldi, Mariano Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo y Diseño. Universidad Tecnológica Nacional. Facultad Regional Santa Fe. Instituto de Desarrollo y Diseño; ArgentinaFil: Grau, Ricardo José Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Martínez, Ernesto Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo y Diseño. Universidad Tecnológica Nacional. Facultad Regional Santa Fe. Instituto de Desarrollo y Diseño; Argentin

Codoñer House - Alcàsser, Valencia. Spain

[EN] Codoñer house is a Family House project, the result of a close dialogue and work with the client, a family of four members. The idea is simple, to enclose a courtyard with a stonewall on which it rests, two abstract pieces of rigorous geometry built in concrete. This courtyard is the main element of the house, one more inhabited space, a roofless room in charge of making the formal and functional arrangement of the rest of the spaces. And it is by virtue of natural light, formal expression of time, how these spaces come to life and acquire meaning. It is the spring that qualifies and makes them habitable.[ES] La casa Codoñer es un proyecto de Casa Familiar, resultado del estrecho diálogo y trabajo conjunto con el cliente, una familia de cuatro miembros. La idea es sencilla, encerrar un patio con un muro perimetral de piedra sobre el que descansan apoyadas, dos piezas abstractas de rigurosa geometría construidas en hormigón. Es este patio el elemento principal de la casa, un espacio habitado más, una estancia sin techo y el encargado de realizar la disposición formal y funcional del resto de los espacios de la vivienda. Y es, en virtud de la luz natural, expresión formal del tiempo, como estos espacios cobran vida y adquieren significado. Es el resorte que los cualifica hasta hacerlos habitables.Grau Fernández, J. (2020). Casa Codoñer - Alcàsser, Valencia. España. En IX Congreso Internacional Arquitectura Blanca. Editorial Universitat Politècnica de València. https://doi.org/10.4995/CIAB9.2020.10660OC