32,503 research outputs found
Adaptive Bayesian decision feedback equalizer for dispersive mobile radio channels
The paper investigates adaptive equalization of time dispersive mobile ratio fading channels and develops a robust high performance Bayesian decision feedback equalizer (DFE). The characteristics and implementation aspects of this Bayesian DFE are analyzed, and its performance is compared with those of the conventional symbol or fractional spaced DFE and the maximum likelihood sequence estimator (MLSE). In terms of computational complexity, the adaptive Bayesian DFE is slightly more complex than the conventional DFE but is much simpler than the adaptive MLSE. In terms of error rate in symbol detection, the adaptive Bayesian DFE outperforms the conventional DFE dramatically. Moreover, for severely fading multipath channels, the adaptive MLSE exhibits significant degradation from the theoretical optimal performance and becomes inferior to the adaptive Bayesian DFE
Collective Spin-Density-Wave Response Perpendicular to the Chains of the Quasi One-Dimensional Conductor (TMTSF)2PF6
Microwave experiments along all three directions of the spin-density-wave
model compound (TMTSF)PF reveal that the pinned mode resonance is
present along the and axes. The collective transport is
considered to be the fingerprint of the condensate. In contrast to common quasi
one-dimensional models, the density wave also slides in the perpendicular
direction. The collective response is absent along the least
conducting direction.Comment: 3 pages, 4 figure
Neonatal weight loss in breast and formula-fed infants
We have observed an increase in the number of breast fed babies presenting with dehydration and/or failure to thrive because of lactation failure and non-recognition of feeding problems. Recent reports1,2 support this experience and recommend monitoring of the weight of infants through the neonatal period. However, these reports acknowledge uncertainty as to what actually constitutes normal neonatal weight loss. Maisels and colleagues published two studies which have been quoted as giving guidance on normal loss. Both studies were designed primarily to study factors that influence breast milk jaundice. The first3 reported a mean weight loss of about 6% in 100 unselected well babies during the first 3 days. The subsequent study4 reported a mean weight loss of 6.86% in 186 infants. The timescale over which babies were weighed was not clearly indicated, although it may have only been 2-3 days. The sample was neither population based nor randomly selected, being largely preselected because of the presence of more pronounced jaundice. The distribution of data points for early neonatal weight loss are likely to be skewed, yet both studies reported the results as mean (SD). Owing to the design and method of data presentation, these studies cannot reliably inform the debate as to what constitutes the norm. Marchini and colleagues published reports also designed primarily to study other issues. One5 indicated a mean early weight loss of 5.7%. Measurements were recorded over a three day period, and no indication is given of the skewness of the data. Another study6 reported a median weight loss of about 6% recorded over a four day period. At least one baby lost > 15% of his/her birth weight during this time, but there is no clear information as to the frequency with which more extreme degrees of weight loss are observed
Sequence-Based Analysis of Thermal Adaptation and Protein Energy Landscapes in an Invasive Blue Mussel (Mytilus galloprovincialis).
Adaptive responses to thermal stress in poikilotherms plays an important role in determining competitive ability and species distributions. Amino acid substitutions that affect protein stability and modify the thermal optima of orthologous proteins may be particularly important in this context. Here, we examine a set of 2,770 protein-coding genes to determine if proteins in a highly invasive heat tolerant blue mussel (Mytilus galloprovincialis) contain signals of adaptive increases in protein stability relative to orthologs in a more cold tolerant M. trossulus. Such thermal adaptations might help to explain, mechanistically, the success with which the invasive marine mussel M. galloprovincialis has displaced native species in contact zones in the eastern (California) and western (Japan) Pacific. We tested for stabilizing amino acid substitutions in warm tolerant M. galloprovincialis relative to cold tolerant M. trossulus with a generalized linear model that compares in silico estimates of recent changes in protein stability among closely related congeners. Fixed substitutions in M. galloprovincialis were 3,180.0 calories per mol per substitution more stabilizing at genes with both elevated dN/dS ratios and transcriptional responses to heat stress, and 705.8 calories per mol per substitution more stabilizing across all 2,770 loci investigated. Amino acid substitutions concentrated in a small number of genes were more stabilizing in M. galloprovincialis compared with cold tolerant M. trossulus. We also tested for, but did not find, enrichment of a priori GO terms in genes with elevated dN/dS ratios in M. galloprovincialis. This might indicate that selection for thermodynamic stability is generic across all lineages, and suggests that the high change in estimated protein stability that we observed in M. galloprovincialis is driven by selection for extra stabilizing substitutions, rather than by higher incidence of selection in a greater number of genes in this lineage. Nonetheless, our finding of more stabilizing amino acid changes in the warm adapted lineage is important because it suggests that adaption for thermal stability has contributed to M. galloprovincialis' superior tolerance to heat stress, and that pairing tests for positive selection and tests for transcriptional response to heat stress can identify candidates of protein stability adaptation
Confined compression of collagen hydrogels
Reconstituted collagen hydrogels are often used for in vitro studies of cell-matrix interaction and as scaffolds for tissue engineering. Understanding the mechanical and transport behaviours of collagen hydrogels is therefore extremely important, albeit difficult due to their very high water content (typically > 99.5%). In the present study the mechanical behaviour of collagen hydrogels in confined compression was investigated using biphasic theory (J. Biomech. Eng. 102 (1980) 73), to ascertain whether the technique is sufficiently sensitive to determine differences in the characteristics of hydrogels of between 0.2% and 0.4% collagen. Peak stress, equilibrium stress, aggregate modulus and hydraulic permeability of the hydrogels exhibited sensitivity to collagen content, demonstrating that the technique is clearly able to discriminate between hydrogels with small differences in collagen content and may also be sensitive to factors that affect matrix remodelling. The results also offer additional insight into the deformation-dependent permeability of collagen hydrogels. This study suggests that confined compression, together with biphasic theory, is a suitable technique for assessing the mechanical properties of collagen hydrogels
Genetic alterations and cancer formation in a European flatfish at sites of different contamination burdens
Fish diseases are an indicator for marine ecosystem health since they provide a biological end-point of historical exposure to stressors. Liver cancer has been used to monitor the effects of exposure to anthropogenic pollution in flatfish for many years. The prevalence of liver cancer can exceed 20%. Despite the high prevalence and the opportunity of using flatfish to study environmentally induced cancer, the genetic and environmental factors driving tumor prevalence across sites are poorly understood. This study aims to define the link between genetic deterioration, liver disease progression, and anthropogenic contaminant exposures in the flatfish dab (Limanda limanda). We assessed genetic changes in a conserved cancer gene, Retinoblastoma (Rb), in association with histological diagnosis of normal, pretumor, and tumor pathologies in the livers of 165 fish from six sites in the North Sea and English Channel. The highest concentrations of metals (especially cadmium) and organic chemicals correlated with the presence of tumor pathology and with defined genetic profiles of the Rb gene, from these sites. Different Rb genetic profiles were found in liver tissue near each tumor phenotype, giving insight into the mechanistic molecular-level cause of the liver pathologies. Different Rb profiles were also found at sampling sites of differing contaminant burdens. Additionally, profiles indicated that histological “normal” fish from Dogger sampling locations possessed Rb profiles associated with pretumor disease. This study highlights an association between Rb and specific contaminants (especially cadmium) in the molecular etiology of dab liver tumorigenesis
Time dependent diffusion in a disordered medium with partially absorbing walls: A perturbative approach
We present an analytical study of the time dependent diffusion coefficient in
a dilute suspension of spheres with partially absorbing boundary condition.
Following Kirkpatrick (J. Chem. Phys. 76, 4255) we obtain a perturbative
expansion for the time dependent particle density using volume fraction of
spheres as an expansion parameter. The exact single particle -operator for
partially absorbing boundary condition is used to obtain a closed form
time-dependent diffusion coefficient accurate to first order in the
volume fraction . Short and long time limits of are checked against
the known short-time results for partially or fully absorbing boundary
conditions and long-time results for reflecting boundary conditions. For fully
absorbing boundary condition the long time diffusion coefficient is found to be
, to the first order of
perturbation theory. Here is small but non-zero, the diffusion
coefficient in the absence of spheres, and the radius of the spheres. The
validity of this perturbative result is discussed
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