Visual and Chemical Prey Cues as Complementary Predator Attractants in a Tropical Stream Fish Assemblage

To date, little attention has been devoted to possible complementary effects of multiple forms of public information similar information on the foraging behaviour of predators. In order to examine how predators may incorporate multiple information sources, we conducted a series of predator attraction trials in the Lower Aripo River, Trinidad. Four combinations of visual (present or absent) and chemical cues (present or absent) from each of two prey species were presented. The occurrences of three locally abundant predatory species present within a 1 m radius of cue introduction sites were recorded. The relative attractiveness of cue type to each predator was directly related to their primary foraging modes, with visual ambush predators demonstrating an attraction to visual cues, benthivores to chemical cues, and active social foragers demonstrating complementary responses to paired cues. Predator species-pair counts were greatest in response to cues from the more abundant prey species, indicating that individuals may adopt riskier foraging strategies when presented with more familiar prey cues. These differences in predator attraction patterns demonstrate complementary effects of multiple sensory cues on the short-term habitat use and foraging behaviour of predators under fully natural conditions

Nonconsumptive Effects of Predation and Impaired Chemosensory Risk Assessment on an Aquatic Prey Species

Weak levels of acidity impair chemosensory risk assessment by aquatic species which may result in increased predator mortalities in the absence of compensatory avoidance mechanisms. Using replicate populations of wild juvenile Atlantic salmon (Salmo salar) in neutral and acidic streams, we conducted a series of observational studies and experiments to identify differences in behaviours that may compensate for the loss of chemosensory information on predation risk. Comparing the behavioural strategies of fish between neutral and acidic streams may elucidate the influence of environmental degradation on nonconsumptive effects (NCEs) of predation. Salmon in acidic streams are more active during the day than their counterparts in neutral streams, and are more likely to avoid occupying territories offering fewer physical refugia from predators. Captive cross-population transplant experiments indicate that at equal densities, salmon in acidic streams do not demonstrate relative decreases in growth rate as a result of their different behavioural strategies. Instead, altering diel activity patterns to maximize visual information use and occupying relatively safer territories appear sufficient to offset increased predation risk in acidic streams. Additional strategies such as elevated foraging rates during active periods or adopting riskier foraging tactics are necessary to account for the observed similarities in growth rates

Gamma-Rays from Single Lobe Supernova Explosions

Multi-dimensional simulations of the neutrino-driven mechanism behind core-collapse supernovae have long shown that the explosions from this mechanism would be asymmetric. Recently, detailed core-collapse simulations have shown that the explosion may be strongest in a single direction. We present a suite of simulations modeling these ``single-lobe'' supernova explosions of a 15 solar mass red supergiant star, focusing on the effect these asymmetries have on the gamma-ray emission and the mixing in the explosion. We discuss how asymmetries in the explosion mechanism might explain many of the observed ``asymmetries'' of supernovae, focusing on features of both supernova 1987A and the Cas A supernova remnant. In particular, we show that single-lobe explosions provide a promising solution to the redshifted iron lines of supernova 1987A. We also show that the extent of mixing for explosive burning products depends sensitively on the angular profile of the velocity asymmetry and can be much more extensive than previously assumed.Comment: 39 pages, 18 figures, submitted to ApJ Version with high resolution figures can be found at http://qso.lanl.gov/~cl

Representation of multimorbidity and frailty in the development and validation of kidney failure prognostic prediction models:a systematic review

Background: Prognostic models that identify individuals with chronic kidney disease (CKD) at greatest risk of developing kidney failure help clinicians to make decisions and deliver precision medicine. It is recognised that people with CKD usually have multiple long-term health conditions (multimorbidity) and often experience frailty. We undertook a systematic review to evaluate the representation and consideration of multimorbidity and frailty within CKD cohorts used to develop and/or validate prognostic models assessing the risk of kidney failure. Methods: We identified studies that described derivation, validation or update of kidney failure prognostic models in MEDLINE, CINAHL Plus and the Cochrane Library – CENTRAL. The primary outcome was representation of multimorbidity or frailty. The secondary outcome was predictive accuracy of identified models in relation to presence of multimorbidity or frailty.Results: Ninety-seven studies reporting 121 different kidney failure prognostic models were identified. Two studies reported prevalence of multimorbidity and a single study reported prevalence of frailty. The rates of specific comorbidities were reported in a greater proportion of studies: 67.0% reported baseline data on diabetes, 54.6% reported hypertension and 39.2% reported cardiovascular disease. No studies included frailty in model development, and only one study considered multimorbidity as a predictor variable. No studies assessed model performance in populations in relation to multimorbidity. A single study assessed associations between frailty and the risks of kidney failure and death.Conclusions: There is a paucity of kidney failure risk prediction models that consider the impact of multimorbidity and/or frailty, resulting in a lack of clear evidence-based practice for multimorbid or frail individuals. These knowledge gaps should be explored to help clinicians know whether these models can be used for CKD patients who experience multimorbidity and/or frailty

Fate of an Infectious ERV in Wild and Domestic Cats

Endogenous retroviruses (ERVs) of domestic cats (ERV-DCs) are one of the youngest feline ERV groups in domestic cats (Felis silvestris catus); some members are replication competent (ERV-DC10, ERV-DC18, and ERV-DC14), produce the antiretroviral soluble factor Refrex-1 (ERV-DC7 and ERV-DC16), or can generate recombinant feline leukemia virus (FeLV). Here, we investigated ERV-DC in European wildcats (Felis silvestris silvestris) and detected four loci: ERV-DC6, ERV-DC7, ERV-DC14, and ERV-DC16. ERV-DC14 was detected at a high frequency in European wildcats; however, it was replication defective due to a single G → A nucleotide substitution, resulting in an E148K substitution in the ERV-DC14 envelope (Env). This mutation results in a cleavage-defective Env that is not incorporated into viral particles. Introduction of the same mutation into feline and murine infectious gammaretroviruses resulted in a similar Env dysfunction. Interestingly, the same mutation was found in an FeLV isolate from naturally occurring thymic lymphoma and a mouse ERV, suggesting a common mechanism of virus inactivation. Refrex-1 was present in European wildcats; however, ERV-DC16, but not ERV-DC7, was unfixed in European wildcats. Thus, Refrex-1 has had an antiviral role throughout the evolution of the genus Felis, predating cat exposure to feline retroviruses. ERV-DC sequence diversity was present across wild and domestic cats but was locus dependent. In conclusion, ERVs have evolved species-specific phenotypes through the interplay between ERVs and their hosts. The mechanism of viral inactivation may be similar irrespective of the evolutionary history of retroviruses. The tracking of ancestral retroviruses can shed light on their roles in pathogenesis and host-virus evolution

Provenance and threat-sensitive predator avoidance patterns in wild-caught Trinidadian guppies

The antipredator behaviour of prey organisms is shaped by a series of threat-sensitive trade-offs between the benefits associated with successful predator avoidance and a suite of other fitness-related behaviours such as foraging, mating and territorial defence. Recent research has shown that the overall intensity of antipredator response and the pattern of threat-sensitive trade-offs are influenced by current conditions, including variability in predation risk over a period of days to weeks. Here, we tested the hypothesis that long-term predation pressure will likewise have shaped the nature of the threat-sensitive antipredator behaviour of wild-caught Trinidadian guppies (Poecilia reticulata). Female guppies were collected two populations that have evolved under high- and low-predation pressure, respectively, in the Aripo River, Northern Mountain Range, Trinidad. Under laboratory conditions, we exposed shoals of three guppies to varying concentrations of conspecific damage-released chemical alarm cues. Lower Aripo (high-predation) guppies exhibited the strongest antipredator response when exposed to the highest alarm cue concentration and a graded decline in response intensity with decreasing concentrations of alarm cue. Upper Aripo (low-predation) guppies, however, exhibited a nongraded (hypersensitive) response pattern. Our results suggest that long-term predation pressure shapes not only the overall intensity of antipredator responses of Trinidadian guppies, but also their threat-sensitive behavioural response patterns

B cell sub-types following acute malaria and associations with clinical immunity.

BACKGROUND: Repeated exposure to Plasmodium falciparum is associated with perturbations in B cell sub-set homeostasis, including expansion atypical memory B cells. However, B cell perturbations immediately following acute malaria infection have been poorly characterized, especially with regard to their relationship with immunity to malaria. METHODS: To better understand the kinetics of B cell sub-sets following malaria, the proportions of six B cell sub-sets were assessed at five time points following acute malaria in four to 5 years old children living in a high transmission region of Uganda. B cell sub-set kinetics were compared with measures of clinical immunity to malaria-lower parasite density at the time of malaria diagnosis and recent asymptomatic parasitaemia. RESULTS: Atypical memory B cell and transitional B cell proportions increased following malaria. In contrast, plasmablast proportions were highest at the time of malaria diagnosis and rapidly declined following treatment. Increased proportions of atypical memory B cells were associated with greater immunity to malaria, whereas increased proportions of transitional B cells were associated with evidence of less immunity to malaria. CONCLUSIONS: These findings highlight the dynamic changes in multiple B cell sub-sets following acute, uncomplicated malaria, and how these sub-sets are associated with developing immunity to malaria

Designing a complex intervention for dementia case management in primary care

Background: Community-based support will become increasingly important for people with dementia, but currently services are fragmented and the quality of care is variable. Case management is a popular approach to care co-ordination, but evidence to date on its effectiveness in dementia has been equivocal. Case management interventions need to be designed to overcome obstacles to care co-ordination and maximise benefit. A successful case management methodology was adapted from the United States (US) version for use in English primary care, with a view to a definitive trial. Medical Research Council guidance on the development of complex interventions was implemented in the adaptation process, to capture the skill sets, person characteristics and learning needs of primary care based case managers. Methods: Co-design of the case manager role in a single NHS provider organisation, with external peer review by professionals and carers, in an iterative technology development process. Results: The generic skills and personal attributes were described for practice nurses taking up the case manager role in their workplaces, and for social workers seconded to general practice teams, together with a method of assessing their learning needs. A manual of information material for people with dementia and their family carers was also created using the US intervention as its source. Conclusions: Co-design produces rich products that have face validity and map onto the complexities of dementia and of health and care services. The feasibility of the case manager role, as described and defined by this process, needs evaluation in ‘real life’ settings

Using the spatial population abundance dynamics engine for conservation management

1. An explicit spatial understanding of population dynamics is often critical for effective management of wild populations. Sophisticated approaches are available to simulate these dynamics, but are largely either spatially homogeneous or agentbased, and thus best suited to small spatial or temporal scales. These approaches also often ignore financial decisions crucial to choosing management approaches on the basis of cost-effectiveness. 2. We created a user-friendly and flexible modelling framework for simulating these population issues at large spatial scales – the Spatial Population Abundance Dynamics Engine (SPADE). SPADE is based on the STAR model (McMahon et al. 2010) and uses a reaction-diffusion approach to model population trajectories and a cost-benefit analysis technique to calculate optimal management strategies over long periods and across broad spatial scales. It expands on STAR by incorporating species interactions and multiple concurrent management strategies, and by allowing full user control of functional forms and parameters. 3. We used SPADE to simulate the eradication of feral domestic cats Felis catus on sub-Antarctic Marion Island (Bester et al. 2002) and compared modelled outputs to observed data. The parameters of the best-fitting model reflected the conditions of the management programme, and the model successfully simulated the observed movement of the cat population to the southern and eastern portion of the island under hunting pressure. We further demonstrated that none of the management strategies would likely have been successful within a reasonable timeframe if performed in isolation. 4. SPADE is applicable to a wide range of population management problems, and allows easy generation, modification and analysis of management scenarios. It is a useful tool for the planning, evaluation and optimisation of the management of wild populations, and can be used without specialised training.Appendix S1. SPADE manual.Appendix S2. Details of algorithms used in SPADE.Appendix S3. Details of statistical models.Appendix S4. Source code for SPADE package.Appendix S5. Description of potential issues in using STAR.The development of SPADE was aided extensively by input from the Australian Alps National Parks Cooperative Management Programme’s Feral Horse Working Group, including participants from Parks Victoria, the NSW National Parks and Wildlife Service, the ACT Parks and Conservation Service and Forestry Corporation NSW.http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)2041-210Xhb2017Mammal Research Institut