An Efficient Approximate Model for Elastic Wave Scattering in Plates

The objective of this work is to develop a fast method for modeling time-domain ultrasonic wave scattering in plates. Due to the possible excitation of multiple plate modes and dispersive behavior of these waves, the scattered signal can be very complicated. The model that is presented in the following, can be valuable tool in real-time inspection or development of new inspection techniques for the aircraft safety inspection. Inspection of the structural integrity of an aircraft involves, in part, the inspection of rivots for existence of cracks. Rivots can be checked using eddy-current probes or regular contact ultrasonic transducers. However, for inspection of rivots that are hidden by a top layer (e.g. lap-joints), a better technique may be to excite a guided ultrasonic wave which can travel in the plate under the joint and interrogates the hidden rivot. The scattered signal can be picked up by the same transducer in the pulse-echo mode.</p

Theoretical Aspects of Transient Electromagnetic Field in Finite Sized Conducting Media

It is generally accepted that electromagnetic disturbances diffuse into the bulk region of highly conducting media instead of propagating with wave-like characteristics [1]. This can be explained based on the fact that the high frequency components of the electromagnetic field decay rapidly, leaving the electromagnetic state in the bulk material quasistatic. For the application of this phenomena to practical testing, Ross et al. developed a formalism describing the diffusion of electromagnetic field in a finite thickness conductor and demonstrated the effect of thickness on the time rate of damping of field amplitude [2]

Wave reflection and cut-off frequencies in coupled FE-peridynamic grids

International Journal for Numerical Methods in Engineering Published by John Wiley & Sons, Ltd. Reflections are typically observed when pulses propagate across interfaces. Accordingly, spurious reflections might occur at the interfaces between different models used to simulate the same medium. Examples of such coupled models include classical continuum descriptions with molecular dynamics or peridynamic (PD) grids. In this work, three different coupling approaches are implemented to couple bond-based PDs with finite element (FE) solvers for solid mechanics. It is observed that incorporation of an overlapping zone, over which the coupling between FE and PD occurs, can lead to minimization of the reflected energy compared to a standard force coupling at the FE domain/PD grid interface. However, coupling with other existing methodologies, like the addition of ghost particles, achieves comparable accuracy at lower computational cost. Furthermore, the prudent selection of the discretization parameters is of pivotal importance as they control the high frequency cut-off limit. Mismatch between the cut-off frequencies of the different descriptions can lead to unrealistic results

Transient Lamb Wave Velocity Determination Using Holographic Mapping of Spatial Feautres of Propagating Waves

Measurement of surface displacements resulting from acoustic wave propagation in solids has been used extensively in determining elastic properties of materials [1],[2]. Additionally, examination of acoustic wave propagation in materials has been used as a nondestructive tool in testing the integrity of structures, evaluating the size and position of bulk material defects, determining material dimensions, and in general, characterizing a number of material or structural parameters [3]</p

Histone deacetylases as new therapy targets for platinum-resistant epithelial ovarian cancer

Introduction: In developed countries, ovarian cancer is the fourth most common cancer in women. Due to the nonspecific symptomatology associated with the disease many patients with ovarian cancer are diagnosed late, which leads to significantly poorer prognosis. Apart from surgery and radiotherapy, a substantial number of ovarian cancer patients will undergo chemotherapy and platinum based agents are the mainstream first-line therapy for this disease. Despite the initial efficacy of these therapies, many women relapse; therefore, strategies for second-line therapies are required. Regulation of DNA transcription is crucial for tumour progression, metastasis and chemoresistance which offers potential for novel drug targets. Methods: We have reviewed the existing literature on the role of histone deacetylases, nuclear enzymes regulating gene transcription. Results and conclusion: Analysis of available data suggests that a signifant proportion of drug resistance stems from abberant gene expression, therefore HDAC inhibitors are amongst the most promising therapeutic targets for cancer treatment. Together with genetic testing, they may have a potential to serve as base for patient-adapted therapies

Expression analysis of E-cadherin, Slug and GSK3β in invasive ductal carcinoma of breast

<p>Abstract</p> <p>Background</p> <p>Cancer progression is linked to a partially dedifferentiated epithelial cell phenotype. The signaling pathways Wnt, Hedgehog, TGF-β and Notch have been implicated in experimental and developmental epithelial mesenchymal transition (EMT). Recent findings from our laboratory confirm that active Wnt/β-catenin signaling is critically involved in invasive ductal carcinomas (IDCs) of breast.</p> <p>Methods</p> <p>In the current study, we analyzed the expression patterns and relationships between the key Wnt/β-catenin signaling components- E-cadherin, Slug and GSK3β in IDCs of breast.</p> <p>Results</p> <p>Of the 98 IDCs analyzed, 53 (54%) showed loss/or reduced membranous staining of E-cadherin in tumor cells. Nuclear accumulation of Slug was observed in 33 (34%) IDCs examined. Loss or reduced level of cytoplasmic GSK3β expression was observed in 52/98 (53%) cases; while 34/98 (35%) tumors showed nuclear accumulation of GSK3β. Statistical analysis revealed associations of nuclear Slug expression with loss of membranous E-cadherin (p = 0.001); nuclear β-catenin (p = 0.001), and cytoplasmic β-catenin (p = 0.005), suggesting Slug mediated E-cadherin suppression via the activation of Wnt/β-catenin signaling pathway in IDCs. Our study also demonstrated significant correlation between GSK3β nuclear localization and tumor grade (p = 0.02), suggesting its association with tumor progression.</p> <p>Conclusion</p> <p>The present study for the first time provided the clinical evidence in support of Wnt/β-catenin signaling upregulation in IDCs and key components of this pathway - E-cadherin, Slug and GSK3β with β-catenin in implementing EMT in these cells.</p