Plastic response by dislocation glide in solid helium under dc strain rate loading

We develop a model for the gliding of dislocations and plasticity in solid He-4. This model takes into account the Peierls barrier, multiplication and interaction of dislocations, as well as classical thermally and mechanically activated processes leading to dislocation glide. We specifically examine the dc stress-strain curve and how it is affected by temperature, strain rate, and dislocation density. As a function of temperature and shear strain, we observe plastic deformation and discuss how this may be related to the experimental observation of elastic anomalies in solid hcp He-4 that have been discussed in connection with the possibility of supersolidity or giant plasticity. Our theory gives several predictions for the dc stress strain curves, for example, the yield point and the change in the work-hardening rate and plastic dissipation peak, that can be compared directly to constant strain rate experiments and thus provide bounds on model parameters.Comment: 10 pages, 8 figures; minor revisions of accepted versio

Dislocation induced anomalous softening of solid helium

The classical motion of gliding dislocation lines in slip planes of crystalline solid helium leads to plastic deformation even at temperatures far below the Debye temperature and can affect elastic properties. In this work we argue that the gliding of dislocations and plasticity may be the origin of many observed elastic anomalies in solid He-4, which have been argued to be connected to supersolidity. We present a dislocation motion model that describes the stress-strain $\tau$-$\epsilon$ curves and work hardening rate $d\tau/d\epsilon$ of a shear experiment performed at constant strain rate $\dot{\epsilon}$ in solid helium. The calculated $d\tau/d\epsilon$ exhibits strong softening with increasing temperature due to the motion of dislocations, which mimics anomalous softening of the elastic shear modulus $\mu$. In the same temperature region the motion of dislocations causes dissipation with a prominent peak.Comment: 15 double-spaced pages, 4 figures; revised model parameters to account for low experimental yield stress, otherwise unchange

"Die 'Frau' oder den 'Mann' gibt es realiter überhaupt nicht"

"Dr. Paula-Irene Villa ist begeisterte Tango-Tänzerin, MTV-/ VIVA-Konsumentin und Club-Gängerin. Als Assistentin an der Universität Hannover beschäftigt sie sich mit Körper- und Geschlechtersoziologie, Sozialkonstruktivismus und sozialer Ungleichheit. Im Gespräch für das soz:mag gibt sie einen Vorgeschmack auf das inter-universitäre Kolloquium zum Thema Körpersoziologie (siehe Kasten auf S. 42), welches Ende November in Bern stattfindet. In welcher Beziehung steht der Körper und das Soziale? Inwiefern lassen sich die beiden Sphären überhaupt trennen? Und wer vollzieht diese Trennung? Paula-Irene Villa über die Bedeutung des Körpers in der Soziologie, die Konstruktion von Geschlechterdifferenzen und den ideologischen Kampf gegen 'dicke' Menschen." (Autorenreferat

Plastic Response of Dislocation Glide in Solid Helium under DC Strain-Rate Loading

We develop a model for the gliding of dislocations and plasticity in solid 4He. This model takes into account the Peierls barrier, multiplication and interaction of dislocations, as well as classical thermally and mechanically activated processes leading to dislocation glide. We specifically examine the dc stress-strain curve and how it is affected by temperature, strain rate, and dislocation density. As a function of temperature and shear strain, we observe plastic deformation and discuss how this may be related to the experimental observation of elastic anomalies in solid hcp 4He that have been discussed in connection with the possibility of supersolidity or giant plasticity. Our theory gives several predictions for the dc stress strain curves, for example, the yield point and the change in the work-hardening rate and plastic dissipation peak, that can be compared directly to constant strain-rate experiments and thus provide bounds on model parameters

Dopaminergic and opioidergic regulation during anticipation and consumption of social and nonsocial rewards

The observation of animal orofacial and behavioral reactions has played a fundamental role in research on reward but is seldom assessed in humans. Healthy volunteers (N = 131) received 400 mg of the dopaminergic antagonist amisulpride, 50 mg of the opioidergic antagonist naltrexone, or placebo. Subjective ratings, physical effort, and facial reactions to matched primary social (affective touch) and nonsocial (food) rewards were assessed. Both drugs resulted in lower physical effort and greater negative facial reactions during reward anticipation, especially of food rewards. Only opioidergic manipulation through naltrexone led to a reduction in positive facial reactions to liked rewards during reward consumption. Subjective ratings of wanting and liking were not modulated by either drug. Results suggest that facial reactions during anticipated and experienced pleasure rely on partly different neurochemical systems, and also that the neurochemical bases for food and touch rewards are not identical

The Ursinus Weekly, October 15, 1951

Henning W. Prentis slated as speaker at Founders\u27 Day program, October 24 • Chaplain first Forum speaker on October 31 • Curtain Club adds sixty new members at annual party • New preceptress in charge of 646 Main • 300 books added to Library collection • Piano recital date moved to Nov. 8 • Cub and Key honor given to Jay Kern • Y plans weekend trip, arranges fireside chats • Date announced for civil service exam • WAA to sell socks, Christmas cards • Soph class plans year; Informal dance Nov. 3 • French Club discusses plans • Rev. Creager to speak • Juniors to sponsor G. E. House of Magic • German Club schedules trips and welcomes Inge Rudloff • 12 students become psychology majors • Spirit Committee fans campus enthusiasm • Editorials: No complaints; British voters go to polls; McCarthy vs. free speech • Letter to the editor • Dorm initiations give jokers a release • So the frosh love customs? Scribes of 1955 reveal all • Dr. Miller\u27s family hits high spots in European tour • Four teams open intradorm football • Hockey and soccer are overshadowed, but fortunately have excellent leaders • Dickinson hands Ursinus season\u27s second defeat • Dr. Roelofs keeps athletes in shape • Garnet eleven will play host to Bears Saturday • Alumnae team is undefeated; Faces Owlettes on Saturday • Harry Spangler succeeds Gerry Seeders as head coach of Ursinus court team • Bears defeated by Stevens Tech • Rittenhouse, Feldt to manage girls intramural program • Beardwood Chemical Society hears lecture on narcotics • Lit reading givenhttps://digitalcommons.ursinus.edu/weekly/1523/thumbnail.jp

The Ursinus Weekly, May 21, 1951

Dr. Allan L. Rice confers with Senator E. Kefauver • Awards given to athletes at WAA banquet • Reading Railroad president to address Newcomen group here • WSGA installs new officers at banquet • Curtain Club elects Roberts • Bowens join honorary debating frat, Tau Kappa • Lantern issue due • Y picnic held • Dean Harry A. Cochran to address senior class • MSGA gives out concessions for 1951-52 year • Ruby to arrive shortly; Seniors plan class gift • Various campus groups hold annual elections, installations • Editorials: Backward glance • World escapism attacked; News awareness asked • Poll reveals students\u27 plans • Seniors review elements in their past, grow maudlin as graduation approaches • Scheduling problems plague students, faculty; Difficulties cause practice teachers to groan • Softball team scores two more victories • Dickinson loses to Ursinus nine • Ursinus girls beat East Stroudsburg squad in tennis • Luckless Bruins lose to Lehigh track team • Garnet team halts Millermen\u27s streak; LaSalle defeated, 5-4, to close season • Curtis I crowned softball champs • Cindermen place sixth in Middle Atlantics • Penn girls defeat Ursinus in tennis • Hal Henning\u27s circuit blast beats Drew; Wild pitch defeats Delaware in eleventh • Zeta Chi takes inter-frat track • Health, welfare council meets at Ursinus; Elect new officers • Note of thankshttps://digitalcommons.ursinus.edu/weekly/1570/thumbnail.jp

Genomic Biomarkers and Genome-Wide Loss-of-Heterozygosity Scores in Metastatic Prostate Cancer Following Progression on Androgen-Targeting Therapies

Genomic biomarkers; Prostate cancer; Targeting therapiesBiomarcadores genómicos; Cáncer de próstata; Terapias dirigidasBiomarcadors genòmics; Càncer de pròstata; Teràpies dirigidesPURPOSE To study the impact of standard-of-care hormonal therapies on metastatic prostate cancer (mPC) clinical genomic profiles in real-world practice, with a focus on homologous recombination-repair (HRR) genes. PATIENTS AND METHODS Targeted next-generation sequencing of 1,302 patients with mPC was pursued using the FoundationOne or FoundationOne CDx assays. Longitudinal clinical data for correlative analysis were curated via technology-enabled abstraction of electronic health records. Genomic biomarkers, including individual gene aberrations and genome-wide loss-of-heterozygosity (gLOH) scores, were compared according to biopsy location and time of sample acquisition (androgen deprivation therapy [ADT]-naïve, ADT-progression and post-ADT, and novel hormonal therapies [NHT]-progression), using chi-square and Wilcoxon rank-sum tests. Multivariable analysis used linear regression. False-discovery rate of 0.05 was applied to account for multiple comparisons. RESULTS Eight hundred forty (65%), 132 (10%), and 330 (25%) biopsies were ADT-naïve, ADT-progression, and NHT-progression, respectively. Later-stage samples were enriched for AR, MYC, TP53, PTEN, and RB1 aberrations (all adjusted P values < .05), but prevalence of HRR-related BRCA2, ATM, and CDK12 aberrations remained stable. Primary and metastatic ADT-naïve biopsies presented similar prevalence of TP53 (36% v 31%) and BRCA2 (8% v 7%) aberrations; 81% of ADT-naïve BRCA2-mutated samples presented BRCA2 biallelic loss. Higher gLOH scores were independently associated with HRR genes (BRCA2, PALB2, and FANCA), TP53, and RB1 aberrations, and with prior exposure to hormonal therapies in multivariable analysis. CONCLUSION Prevalence of HRR-gene aberrations remains stable along mPC progression, supporting the use of diagnostic biopsies to guide poly (ADP-ribose) polymerase inhibitor treatment in metastatic castration-resistant prostate cancer. gLOH scores increase with emerging resistance to hormonal therapies, independently of individual HRR gene mutations

The Ursinus Weekly, January 14, 1952

MSGA to enforce campus parking; new fines listed • Navy to send officer here for interviews • FTA hears lecture on visual aid subject • Dr. Phillips attends meeting of foreign student advisors • Forum speaker evaluates Middle East in address • May Queen petitions to go out Feb. 4; Pageant deadline set for February 27 • Rosicrucians add members; Tea is planned • Professors\u27 panel needs questions • Music Club picks Spring operetta • Interest lack hits debating society • Dolman to read • Music Club gives annual recital featuring students • Delta Pi Sigma pledges to work to improve campus • Re-election for Ruby business manager planned by Juniors • Editorials: Is it fair?; We still like heroes • Letters to the editor • English college rules differ from Ursinus\u27 • Engagement announced • Birth announced • Chess provides ground for exercise of mind\u27s caution, logic, memory • Projects planned for improvement of Y rec center • Boobies run acoustics in Bomberger • Bruins topple Haverford 76-59 for first league court victory • Wrestlers defeated by Lafayette team • Marguerite Spencer is chosen captain of 1952 girls\u27 basketball squad • Dorm squads battle for campus court crown • Mack assigned • Bruins register four pins to down Garnet matmen • New record set • Delaware beats Ursinus, 81-52 • Sorority members hold partieshttps://digitalcommons.ursinus.edu/weekly/1532/thumbnail.jp

The Ursinus Weekly, November 19, 1951

Four soloists for Messiah concert named • Fraternities give out bids; Plan parties next week • Student-faculty talents presented for benefit of Campus Chest fund • Kiszonas is new senior class prexy • Red Cross disbands • WSGA hears plans for Student Union • Forum speaker says religious belief implies skeptical aspect • Curtain rises on Private Lives act tomorrow night • Nominees listed for \u2753 yearbook positions • Curtain Club play set for 2-night run • Student tells of conditions in Russia • Senior ball set • Campus Chest campaign reaches half-way mark • Haverford College student panel to argue army conscription here • Editorials: Thanksgiving, 1951; East is world headache • Gigi, French play, opens at Philadelphia theater • Alumni • Letters to the editor • Dr. McClure delivers lecture on education • If Collegeville were in Korea, this could happen • Thanksgiving: Pre and Post • Messiah tradition came with Dr. Philip • Bruins to play benefit in York • East Stroudsburg handed initial defeat by Belles • Bears defeated in finale by unbeaten Susquehanna • Curtis Hall wins interdorm title • Women begin to play in intramural hockey • Susquehanna completes unbeaten, untied year • Band attacked for disinterest • Soccer squad closes its season by losing to Franklin & Marshall team • Nevison lectures to Chem society • Intercollegiate bridge tournament to begin • Pediatrics talk given pre-medders • Square dance enjoyedhttps://digitalcommons.ursinus.edu/weekly/1528/thumbnail.jp