DIGITALIZATION AS A FACTOR OF DEVELOPMENT OF WORLD ECONOMY

This article analyzes digitalization as a factor of development of world economy. It has been established that conversion to the model of digital economy is accompanied by new qualitative modifications of social and economic relations both at the governmental level and at the level of business entities. This process is characterized by new capabilities and hazards. It has been revealed that the fraction of internet economy increases in gross domestic product, though, the digital transformation will deal with all sectors of most countries of the world. At the same time, in order to estimate the efficiency of digital economy, it is necessary to have common and unique procedures, which are currently unavailable. Therefore, the development strategy of digital economy cannot be established just to verify the new concept

Expression of GM3 synthase in human atherosclerotic lesions

10.1016/j.atherosclerosis.2005.04.019Atherosclerosis184163-7

Ru(III) complexes with lonidamine-modified ligands

A series of bifunctional Ru(III) complexes with lonidamine-modified ligands (lonidamine is a selective inhibitor of aerobic glycolysis in cancer cells) was described. Redox properties of Ru(III) complexes were characterized by cyclic voltammetry. An easy reduction suggested a perspective for these agents as their whole mechanism of action seems to be based on activation by metal atom reduction. New compounds demonstrated a more pronounced antiproliferative potency than the parental drug; individual new agents were more cytotoxic than cisplatin. Stability studies showed an increase in the stability of complexes along with the linker length. A similar trend was noted for antiproliferative activity, cellular uptake, apoptosis induction, and thioredoxin reductase inhibition. Finally, at concentrations that did not alter water solubility, the selected new complex evoked no acute toxicity in Balb/c mice. © 2021 by the authors. Licensee MDPI, Basel, Switzerland