OTC analgesics and drug interactions: clinical implications

The risk of drug interactions with concurrent use of multiple medications is a clinically relevant issue. Many patients are unaware that over-the-counter (OTC) analgesics can cause potentially serious adverse effects when used in combination with other common medications such as anticoagulants, corticosteroids, or antihypertensive agents. Of particular significance is the increased risk of upper abdominal gastrointestinal adverse events in patients who take traditional nonsteroidal anti-inflammatory drugs (NSAIDs). This risk is dose dependent and further increased in patients who take more than one NSAID or use NSAIDs in combination with certain other medications. Some NSAIDs may also mitigate the antiplatelet benefits of aspirin and may increase blood pressure in patients with hypertension. Clinicians should be aware of potential drug interactions with OTC analgesics when prescribing new medications. Additionally, patients should be properly counseled on the appropriate and safe use of OTC analgesics

Loop Current Spin-off Eddies, Slope Currents and Dispersal of Reef Fish Larvae from The Flower Gardens National Marine Sanctuary and The Florida Middle Grounds

Large energetic spin—off eddies from Loop Current intrusions into the Gulf of Mexico play a major role in water exchange between the continental shelf and the deep basin in the northern Gulf. Reef fish larvae, spawned on the outer shelf and planktonic during their early life history, are broadly dispersed by this mechanism, but may be lost to the cohort by transport away from suitable settlement habitat. In this study, satellite altimeter data—assimilative ocean model currents (HYCOM) from 2003—2015 are used to calculate kinetic energy of the mixed layer over the upper continental slope (200 m —1000 m) due to eddy interactions with the shelf and to track the dispersal of larvae spawned during core summer (June—August) season. Over the 13 year model period, dispersal into the deep basin from the Flower Gardens National Marine Sanctuary averaged 63.5%, with a high of 90.8% and a low of 34.6%. Dispersal from the Florida Middle Grounds averaged 9.5%, with a high of 23.1% and a low of 0.6%. Temporal dispersal of larvae was associated with trends in turbulent kinetic energy and mean kinetic energy over the continental slope, and varied with the North Atlantic Oscillation Index. Between 2010 and 2011, mean kinetic energy replaced turbulent kinetic energy as the dominant dispersal mechanism

Influence of Some Selected Supplementary Cementitious Materials on Workability and Compressive Strength of Concrete – A Review

Premature deterioration of our nation’s concrete structures has been a persistent and frustrating problem to those responsible for maintaining them as well as to the public. One of the ways to minimize these problems is to make the concrete less permeable by densifying the cementitious paste. This densification is achieved by using a lower water-cement ratio and supplementary cementitious materials (SCMs). Many researchers have successfully provided a rundown of the current facts about the favorable use of supplementary cementitious materials. These summaries contain a limited number of SCMs considered. This paper reviews the influence of twelve (12) selected supplementary cementitious materials, which are; Cupola Furnace Slag Powder (CFSP), Blast Furnace Slag Powder (BFSP), Silica Fume (SF), Fly Ash (FA), Rice Husk Ash (RHA), Metakaolin (MK), Coconut Husk Ash (CHA), Palm Oil Fuel Ash (POFA), Wood Waste Ash (WWA), Sugar Cane Bagasse Ash (SCBA), Corn Cob Ash (CCA), Bamboo Leaf Ash (BLA), workability and compressive strength of concrete, thus providing a larger database of the current facts about the favorable use of industrial and agricultural byproducts in the concrete industry. Review of literature and careful observation of results were used in generating the useful information provided in this paper. This review considered the compressive strength and workability of concrete containing partial substitute of ordinary Portland cement by the aforementioned supplementary cementitious materials. The chemical compositions of each of these selected supplementary cementitious materials were also reported. This study revealed that the incorporation of these twelve SCMs significantly improves the strength and workability of concrete. It is therefore recommended that arrangements be made by those interested in this paper for processing of these SCMs into commercial cement rather than being disposed of as wastes

Use of industrial by-products and natural media to adsorb nutrients, metals and organic carbon from drinking water

• The use of waste media in the water sector results in a robust, sustainable option. • Fly ash and Bayer residue successfully adsorb TOC, nutrients and Cu. • Granular blast furnace slag and pyritic fill have good adsorption potential. • pH adjustment is not necessary for optimal adsorption of contaminants. • Kinetic studies show that at least 60% of adsorption had taken place after 8 h. a b s t r a c t a r t i c l e i n f o Filtration technology is well established in the water sector but is limited by inability to remove targeted contaminants, found in surface and groundwater, which can be damaging to human health. This study optimises the design of filters by examining the efficacy of seven media (fly ash, bottom ash, Bayer residue, granular blast furnace slag (GBS), pyritic fill, granular activated carbon (GAC) and zeolite), to adsorb nitrate, ammonium, total organic carbon (TOC), aluminium, copper (Cu) and phosphorus. Each medium and contaminant was modelled to a Langmuir, Freundlich or Temkin adsorption isotherm, and the impact of pH and temperature (ranging from 10°C to 29°C) on their performance was quantified. As retention time within water filters is important in contaminant removal, kinetic studies were carried out to observe the adsorption behaviour over a 24 h period. Fly ash and Bayer residue had good TOC, nutrient and Cu adsorption capacity. Granular blast furnace slag and pyritic fill, previously un-investigated in water treatment, showed adsorption potential for all contaminants. In general, pH or temperature adjustment was not necessary to achieve effective adsorption. Kinetic studies showed that at least 60% of adsorption had occurred after 8 h for all media. These media show potential for use in a multifunctional water treatment unit for the targeted treatment of specific contaminants

Diagnostic technologies in practice: gay men's narratives of acute or recent HIV infection diagnosis.

Diagnosing HIV-positive gay men through enhanced testing technologies that detect acute HIV infection (AHI) or recent HIV infection provides opportunities for individual and population health benefits. We recruited 25 men in British Columbia who received an acute (n = 13) or recent (n = 12) HIV diagnosis to engage in a longitudinal multiple-methods study over one year or longer. Our thematic analysis of baseline qualitative interviews revealed insights within men's accounts of technologically mediated processes of HIV discovery and diagnosis. Our analysis illuminated the dialectic of new HIV technologies in practice by considering the relationship between advances in diagnostics (e.g., nucleic acid amplification tests) and the users of these medical technologies in clinical settings (e.g., clients and practitioners). Technological innovations and testing protocols have shifted experiences of learning of one's HIV-positive status; these innovations have created new diagnostic categories that require successful interpretation and translation to be rendered meaningful, to alleviate uncertainty, and to support public health objectives

The Effects of a Prescribed Burn on Small Mammals in an Ohio Tallgrass Prairie

Prescribed burning is used on prairies for increased prairie health and to manage the communities of organisms that rely on the prairie’s natural resources. Small mammals are also affected by the burning of prairies. Previous research by Chance in 1986 and Cook in 1950 has established that burning decreases the small mammal capture rates in the burned area because of the habitat loss and rapid change of habitat post-burn that stresses the animals and leads to lower reproductive levels (Chance, 1986). Other studies by Francl and Small also showed that small mammal populations did not return to pre-burn numbers even after 16 months of evaluation (Francl, K. E., & Small, C. J., 2013). We hypothesize that small mammal populations will decrease in the prairie after burning because of a lack of habitat and food source and that they will emigrate from the burning site to nearby prairie or similar habitat. We will use baited Sherman live traps placed at 25 meter intervals in order to estimate the various small mammal populations in each of the observed habitats. We will plot the capture locations on a map of the area in order to track how stress affects the shift of population density