Diagnosis and treatment of paraneoplastic neurological disorders

In about two thirds of cases, patients with paraneoplastic neurological disorders present to the neurologist without a known tumor. Due to the ongoing immune response, this tumor tends to stay biologically relatively benign, and therefore difficult to diagnose. In patients with a known tumor, the neurological symptoms often precede a tumor recurrence. In both scenarios, anti-neuronal antibodies are an invaluable diagnostic help to the clinician, and may be supplemented by other diagnostic tests such as MRI, CSF, and electrophysiology. Tumor therapy remains the mainstay of therapeutic options, although early immune therapy must be started in parallel. It is hoped that the recent fundamental advances in understanding the autoimmune pathology of these disorders, especially the role of cytotoxic T cells, will eventually lead to more effective treatment options

Push it to the limit: Local Group constraints on high-redshift stellar mass functions for Mstar > 10^5 Msun

We constrain the evolution of the galaxy stellar mass function from 2 < z < 5 for galaxies with stellar masses as low as 10^5 Msun by combining star formation histories of Milky Way satellite galaxies derived from deep Hubble Space Telescope observations with merger trees from the ELVIS suite of N-body simulations. This approach extends our understanding more than two orders of magnitude lower in stellar mass than is currently possible by direct imaging. We find the faint end slopes of the mass functions to be alpha= -1.42(+0.07/-0.05) at z = 2 and alpha = -1.57^(+0.06/-0.06) at z = 5, and show the slope only weakly evolves from z = 5 to z = 0. Our findings are in stark contrast to a number of direct detection studies that suggest slopes as steep as alpha = -1.9 at these epochs. Such a steep slope would result in an order of magnitude too many luminous Milky Way satellites in a mass regime that is observationally complete (Mstar > 2*10^5 Msun at z = 0). The most recent studies from ZFOURGE and CANDELS also suggest flatter faint end slopes that are consistent with our results, but with a lower degree of precision. This work illustrates the strong connections between low and high-z observations when viewed through the lens of LCDM numerical simulations

Gold catalyzed multicomponent reactions beyond A3 coupling

The preparation of complex architectures has inspired the search for new methods and new processes in organic synthesis. Multicomponent reactions have become an interesting approach to achieve such molecular diversity and complexity. This review intends to illustrate important gold-catalyzed examples for the past ten years leading to interesting skeletons involved in biologically active compounds

Adsorption geometry and electronic structure of iron phthalocyanine on Ag surfaces: A LEED and photoelectron momentum mapping study

We present a comprehensive study of the adsorption behavior of iron phthalocyanine on the low-index crystal faces of silver. By combining measurements of the reciprocal space by means of photoelectron momentum mapping and low energy electron diffraction, the real space adsorption geometries are reconstructed. At monolayer coverage ordered superstructures exist on all studied surfaces containing one molecule in the unit cell in case of Ag(100) and Ag(111), and two molecules per unit cell for Ag(110). The azimuthal tilt angle of the molecules against the high symmetry directions of the substrate is derived from the photoelectron momentum maps. A comparative analysis of the momentum patterns on the substrates with different symmetry indicates that both constituents of the twofold degenerate FePc lowest unoccupied molecular orbital are occupied by charge transfer from the substrate at the interface

TimeMachine: Timeline Generation for Knowledge-Base Entities

We present a method called TIMEMACHINE to generate a timeline of events and relations for entities in a knowledge base. For example for an actor, such a timeline should show the most important professional and personal milestones and relationships such as works, awards, collaborations, and family relationships. We develop three orthogonal timeline quality criteria that an ideal timeline should satisfy: (1) it shows events that are relevant to the entity; (2) it shows events that are temporally diverse, so they distribute along the time axis, avoiding visual crowding and allowing for easy user interaction, such as zooming in and out; and (3) it shows events that are content diverse, so they contain many different types of events (e.g., for an actor, it should show movies and marriages and awards, not just movies). We present an algorithm to generate such timelines for a given time period and screen size, based on submodular optimization and web-co-occurrence statistics with provable performance guarantees. A series of user studies using Mechanical Turk shows that all three quality criteria are crucial to produce quality timelines and that our algorithm significantly outperforms various baseline and state-of-the-art methods.Comment: To appear at ACM SIGKDD KDD'15. 12pp, 7 fig. With appendix. Demo and other info available at http://cs.stanford.edu/~althoff/timemachine

A Predicted Correlation Between Age Gradient and Star Formation History in FIRE Dwarf Galaxies

We explore the radial variation of star formation histories in dwarf galaxies simulated with Feedback In Realistic Environments (FIRE) physics. The sample contains 9 low-mass field dwarfs with M_ star = 10^5 - 10^7 M_sun from previous FIRE results, and a new suite of 17 higher mass field dwarfs with M_star = 10^7 - 10^9 M_sun introduced here. We find that age gradients are common in our dwarfs, with older stars dominant at large radii. The strength of the gradient correlates with overall galaxy age such that earlier star formation produces a more pronounced gradient. The relation between formation time and strength of the gradient is driven by both mergers and star-formation feedback. Mergers can both steepen and flatten the age gradient depending on the timing of the merger and star formation history of the merging galaxy. In galaxies without significant mergers, early feedback pushes stars to the outskirts at early times. Interestingly, among galaxies without mergers, those with large dark matter cores have flatter age gradients because these galaxies have more late-time feedback. If real galaxies have age gradients as we predict, stellar population studies that rely on sampling a limited fraction of a galaxy can give a biased view of its global star formation history. We show that central fields can be biased young by a few Gyrs while outer fields are biased old. Fields positioned near the 2D half-light radius will provide the least biased measure of a dwarf galaxy's global star formation history.Comment: 13 pages, 8 figures. Submitted to MNRAS, comments welcom

El hormigón armado en Cataluña (1898-1929): cuatro empresas y su relación con la arquitectura

Between 1898 and 1929 various business initiatives that introduced reinforced concrete in its architecture developed in Catalonia. This article studies the following four companies: Anónima Claudio Duran - Construcciones Monier, Marial Hermanos - Sociedad Colectiva, Construcciones y Pavimentos, S. A. and Material y Obras, S. A. Only thorough knowledge of the production complexities that studies these companies, their technicians and works in all its complexity will allow us to assess how reinforced concrete transformed the construction sector, with new companies of a different productive scale. However, the depressed economic cycle of 1929-1952 weighed down any initiative and artificially lengthened what was left of traditional “Catalan construction”.Entre 1898 y 1929 se desarrollaron en Cataluña variadas iniciativas empresariales que introdujeron el hormigón armado en la arquitectura. En el artículo se estudian las empresas Anónima Claudio Duran - Construcciones Monier, Marial Hermanos - Sociedad Colectiva, Construcciones y Pavimentos, S. A., y Material y Obras, S. A. Se propone una aproximación al entramado productivo que estudie las empresas, sus técnicos y sus obras en toda su complejidad con la intención de valorar cómo el hormigón armado transformó el sector de la construcción, con nuevas empresas de otra escala productiva. Sin embargo, el ciclo económico depresivo 1929-1952 lastró estas iniciativas y alargó artificialmente los restos de la tradicional «construcción catalana»