Extraction and Evaluation of Mucilage of Persea Duthiei as a Tablet Binder

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BASIC CONCEPT OF PROCESS VALIDATION IN SOLID DOSAGE FORM (TABLET): A REVIEW

Process validation is an essential component for the safety of drug product and also to maintain the quality of the product. Process validation is the fundamental component for assuring the quality system used by pharmaceutical industries. Process validation is the key element to assure the identity, purity, safety, efficacy and also maintaining the quality of final product. The Process validation precisely focused on the aim, method of analysis, and knowledge. The Process validation establishes the flexibilities and limitations which are faced during the manufacturing process; the variables are controlled for attaining the desired attributes, which assures a consistency in quality of product throughout the product life. In this article an overview is given on process validation with special reference to tablet

A REVIEW ON CLEANING VALIDATION IN PHARMACEUTICAL INDUSTRY

In pharmaceutical industry there are some possibilities of contamination and cross-contamination because of improper cleaning of equipment, apparatus, processing area or the starting material, this can lead to severe hazards, therefore in pharmaceutical industry we can’t afford any contamination as well as cross contamination. This can be minimized by proper cleaning of equipment, apparatus as well as the processing area. TheIndustry wants to achieve these main goals with the help of GMP. This review focused on the different types of cleaning process adapted by pharmaceutical industry, how the process of cleaning validation is done. In the cleaning validation different critical parameter, factor, material and critical process are monitored and validated so that the cleaning consistency can be achieved and documented accordingly. Keywords: Cleaning validation, contamination, clean in place, clean out of place, swab sampling, worst cas

Formulation and Evaluation of Ginger Extract Loaded Nanoemulgel for the Treatment of Rheumatoid Arthritis

Ginger is a potent anti-inflammatory; in the present study the nanoemulgel of ginger extract was formulated for treating rheumatoid arthritis through topical application. The main objective of nanoemulgel formulation was to enhance the bioavailability of ginger extract through topical route and also to reduce the dose of ginger extract. First the nanoemulsion was prepared with the help of ternary phase diagram, using water titration method. The Smix (surfactant and co-surfactant) and extract were mixed together then titrated with water. The Smix was used at the ratio of 1:1, 1:2, and 2:1. The isopropyl myristate is used as oil, tween 80 as surfactant, ethanol as co-surfactant and water was used as aqueous phase and, 32 formulations were prepared. The particle size was found in the range of 60.32 to 230.8nm for formulations F1 to F4. The zeta potential was found between -16.6 to -24.4 and the polydispersibility index was found to be 0.687 to 0.892. Nanoemulsion was converted into nanoemulgel by using carbopol 934 as gelling agent in various concentrations. The rheological properties, spreadability, pH, thermodynamic stability and drug release were also determined. On the basis of thermodynamic stability, spreadability and drug release, the nanoemulgel F4* was considered as best formulation. Keywords: nanoemulgel, nanoemulsion, ternary phase diagram, rheumatoid arthritis, ginger extract, co-surfactan

Insights into the Recent Advances in Nanomaterial Based Electrochemical Sensors for Pesticides in Food

Food safety is one of the rising concerns challenging all over the world and the analysis and determination of food contaminants to ensure the quality of food is highly inevitable. Electroanalytical sensors are a versatile tool for the accurate monitoring of food samples from the pollutants. Pesticides are one of the major sources of food pollutants and their impacts on human health is also very dangerous. This will trigger the researchers to develop more and more sensitive devices to monitor the level of various pesticides in various food samples, especially in agricultural products. Electrochemical sensors fabricated using nanocomposites offers more sensitive electrochemical response in the detection of these pesticides than traditional unmodified electrodes. This prompted us to write a mini review on the electrochemical sensors for pesticides in food using nanomaterials as modifiers from some of the previous reports. This review will motivate the experts working in this area to develop highly efficient sensing devices for pesticides, beneficial to the society as well

Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

A double burden of malnutrition occurs when individuals, household members or communities experience both undernutrition and overweight. Here, we show geospatial estimates of overweight and wasting prevalence among children under 5 years of age in 105 low- and middle-income countries (LMICs) from 2000 to 2017 and aggregate these to policy-relevant administrative units. Wasting decreased overall across LMICs between 2000 and 2017, from 8.4% (62.3 (55.1–70.8) million) to 6.4% (58.3 (47.6–70.7) million), but is predicted to remain above the World Health Organization’s Global Nutrition Target of <5% in over half of LMICs by 2025. Prevalence of overweight increased from 5.2% (30 (22.8–38.5) million) in 2000 to 6.0% (55.5 (44.8–67.9) million) children aged under 5 years in 2017. Areas most affected by double burden of malnutrition were located in Indonesia, Thailand, southeastern China, Botswana, Cameroon and central Nigeria. Our estimates provide a new perspective to researchers, policy makers and public health agencies in their efforts to address this global childhood syndemic

CAPSULE A Programming Language Code Compression Technique

Abstract—In present era internet &amp; large scale scientific research are the most prominent user of large amount of data transmission. Since there is a trade of between efficiency of internet and size of the data being transmitted, so less size data can reach fast and efficiently. Therefore, compressing the data provide a significant change in efficiency of the data transmission. Also it helps in transmission of data efficiently over large scale research in various fields. And on the other side data which is stored on storage disk has some statistical redundancy, which consume unnecessary space and it can be solved by compressing the data

Three new species of Impatiens (Balsaminaceae) from southern Western Ghats, Kerala

Three new species of Impatiens, Impatiens achudanandanii, I. danii, and I. shailajae, are described from Thiruvananthapuram and Idukki districts of Kerala state (SW-India). Impatiens achudanandanii is similar to I. courtallensis and I. herbicola; I. danii to I. goughii and I. shailajae is to I. minae and I. scapiflora. The newly described taxa are readily distinguished from their allied species by unique character combinations, viz. shape of lateral sepal, lower sepal, dorsal petal, seed and pollen morphology. Detailed descriptions along with illustrations and photographs are provided