80 research outputs found
DiisopropÂyl{2-[2-(2-oxopyrrolidin-1-yl)acetamido]ethÂyl}ammonium hydrogen sulfate
The structure of the title compound, C14H28N3O2
+·HSO4
−, a nootropic drug (pramiracetam) investigated for cognition-enhancing properties, is closely similar to that of the previously determined acetonitrile solvate, both structures being characterized by the presence of ribbons of hydrogen-bonded ions. The pyrrolidine ring adopts an envelope conformation
Quantum-fluctuation-induced repelling interaction of quantum string between walls
Quantum string, which was brought into discussion recently as a model for the
stripe phase in doped cuprates, is simulated by means of the
density-matrix-renormalization-group method. String collides with adjacent
neighbors, as it wonders, owing to quantum zero-point fluctuations. The energy
cost due to the collisions is our main concern. Embedding a quantum string
between rigid walls with separation d, we found that for sufficiently large d,
collision-induced energy cost obeys the formula \sim exp (- A d^alpha) with
alpha=0.808(1), and string's mean fluctuation width grows logarithmically \sim
log d. Those results are not understood in terms of conventional picture that
the string is `disordered,' and only the short-wave-length fluctuations
contribute to collisions. Rather, our results support a recent proposal that
owing to collisions, short-wave-length fluctuations are suppressed, but
instead, long-wave-length fluctuations become significant. This mechanism would
be responsible for stabilizing the stripe phase
ChemInform Abstract: Synthetic and Analytical Aspects of the Chemistry of Piracetam-Type Substituted Pyrrolidines. A Review
The Danish lung cancer registry: A nationwide validation study
BACKGROUND: This study evaluates the validity of the information in the Danish Lung Cancer Registry (DLCR). Since 2000, the DLCR has been a tool for monitoring interventions and outcome of all Danish lung cancer patients with the intent to streamline and improve treatment and survival. The DLCR receives information from the Danish Patient Registries in addition to clinical information from the treating physicians. In the year 2022, more than 50 papers have been published using DLCR as a data source. However, the DLCR has not previously been validated.METHODS: A random sample of 1000 patients diagnosed with non-small cell lung cancer from 2014 to 2016 and recorded in the DLCR were included for validation. Medical records were reviewed and were considered as the "gold standard" to which data listed in the DLCR were compared.RESULTS: Information was retrieved from medical charts for all patients. Agreement on stage at diagnosis was 90.1 % (95 % CI 88.0-91.9) and on date of diagnoses was 93.8 (95 % CI 92.1-93.2). Agreement on smoking status in pack years (+/- 10 pack years) was 91.2 % (95 % CI 88.6-93.2). The positive predictive value of treatment intent was 87.4 (95 % CI 85.1-89.6).CONCLUSION: The data in the DLCR are complete, detailed and accurate. The comparison of data from the DLCR with the medical records revealed overall high validity of the data in the registry.</p
Identification of a putative binding site for 5-alkyl-benzothiadiazides in the AMPA receptor dimer interface
Early detection and assertive community treatment of young psychotics:the Opus Study Rationale and design of the trial
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