Determination of total respiratory compliance during artificial ventilation

The main objective of the study presented in this thesis has been the investigation of mechanisms related to the decrease in airway pressure during an inspiratory pause in mechanically ventilated subjects. In particular, we have paid attention to two of these mechanisms, i.e. viscoelasticity and the in:fl.uence of continuous gas exchange on lung volume. We aimed at estimat-_ ing the errors in the determination of CRs when assuming the pressure after an inspiratory pause of 1.5 s to be equal to 'the' static recoil pressure of the respiratory system, which is a common assumption in clinical practice [57,90,98]. In addition we aimed at an evaluation of other methods for the estimation of CRs during mechanical ventilation. This study was performed in animals for reasons oflarge series of observations in each subject in order to evaluate the accuracy and the reliability of a diversity of standardized methods for the estimation of CRS· We have used piglets

Diffusion tensor imaging of the cortical plate and subplate in very-low-birth-weight infants

Background: Many intervention studies in preterm infants aim to improve neurodevelopmental outcome, but short-term proxy outcome measurements are lacking. Cortical plate and subplate development could be such a marker. Objective: Our aim was to provide normal DTI reference values for the cortical plate and subplate of preterm infants. Materials and methods: As part of an ongoing study we analysed diffusion tensor imaging (DTI) images of 19 preterm infants without evidence of injury on conventional MRI, with normal outcome (Bayley-II assessed at age 2), and scanned in the first 4 days of life. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values in the frontal and temporal subplate and cortical plate were measured in single and multiple voxel regions of interest (ROI) placed on predefined regions. Results: Using single-voxel ROIs, statistically significant inverse correlation was found between gestational age (GA) and FA of the frontal (r = -0.5938, P = 0.0058) and temporal (r = -0.4912, P = 0.0327) cortical plate. ADC values had a significant positive correlation with GA in the frontal (r = 0.5427, P = 0.0164) and temporal (r = 0.5540, P = 0.0138) subplate. Conclusion: Diffusion tensor imaging allows in vivo exploration of the evolving cortical plate and subplate. We provide FA and ADC values of the subplate and cortical plate in very-low-birth-weight (VLBW) infants with normal developmental outcome that can be used as reference values

ST segment depression criteria and the prevalence of silent cardiac ischemia in hypertensives

The reported prevalence of silent cardiac ischemia as assessed by ambulatory electrocardiographic recording varies widely. The influence of the stringency of the analysis criteria has never been reported. We performed 24-hour, 12-lead ambulatory electrocardiographic recording in patients with hypertension but without proven coronary artery disease. The recordings were analyzed according to strict ST segment depression criteria adapted from the American College of Cardiology/American Heart Association guidelines and according to basic ST segment depression criteria adapted from studies with only concise descriptions of ambulatory electrocardiographic recording analysis. Also, we performed 24-hour ambulatory blood pressure monitoring. More than 4400 hours of ambulatory electrocardiographic recording and ambulatory blood pressure monitoring in 194 patients with hypertension were analyzed. Medication was withdrawn in 45% of the patients. The average systolic blood pressure during the day was 152+/-13 (mean+/-SD); diastolic blood pressure was 94+/-17 mm Hg. According to the basic ST segment depression criteria, we found a prevalence of silent ischemia of 11.3%, and with the strict criteria the prevalence was 5.2%. The patients who were considered positive according to the basic criteria but not according to the strict criteria (false-positive) in the majority of cases (58%) had depression of an elevated baseline ST segment. We found a lower prevalence of silent cardiac ischemia as assessed by ambulatory electrocardiographic recording than generally reported. The stringency of applied analysis criteria appear to play an important role in this outcom

Comparison of Portapres with standard sphygmomanometry in pregnancy

BACKGROUND: Continuous beat-to-beat noninvasive blood pressure (BP) measurement is possible with Portapres. It constructs finger arterial waveforms beat-to-beat. Dedicated software is used to analyze the arterial waveforms. A new technique has been developed to reconstruct brachial intra-arterial pressure that uses return to flow (RTF). This method has been validated against invasive intra-arterial measurements in nonpregnant individuals. OBJECTIVES: To validate Portapres in normal and preeclamptic pregnant women against standard aneroid sphygmomanometry according to Riva-Rocci-Korotkoff (RRK). METHODS: In 30 normotensive (10 in each trimester) and 20 preeclamptic women, two trained observers blinded from each other's results took BP measurements with a standard sphygmomanometer. These measurements were compared with sequential same-arm averaged measurements obtained during 30 sec by Portapres, following protocols from the Association for the Advancement of Medical Instrumentation (AAMI, mean accepted difference < or = 5 mmHg, SD < or = 8) and British Hypertension Society (BHS, gradings A down to D). RESULTS: A total of 150 measurement pairs were analyzed. Cumulative percentages of absolute pressure differences for all women (BHS) and mean pressure differences (SD) for different trimesters and preeclampsia (AAMI) between sphygmomanometry and Portapres were calculated. Overall, mean difference (SD) for systolic BP was 5 (SD 8) and for diastolic BP was -3 (SD 8), although analysis of variance revealed a significant effect for preeclampsia on diastolic differences between the two methods of BP measurement ( p <0.001). CONCLUSIONS: Portapres with RTF, developed to equal intra-arterial brachial pressure, compares reasonably well to RRK and overall meets the criteria set by the AAMI. According to the BHS, Portapres receives a B-grading for diastolic BP and a C-grading for systolic BP. As Portapres measures BP and calculates cardiac output continuously and noninvasively, it would appear worthwhile to further evaluate this device in pathological pregnancie

Noninvasive Blood Pressure Measurement by the Nexfin Monitor During Reduced Arterial Pulsatility: A Feasibility Study

Noninvasive blood pressure measurements are difficult when arterial pulsations are reduced, as in patients supported by continuous flow left ventricular assist devices (cf-LVAD). We evaluated the feasibility of measuring noninvasive arterial blood pressure with the Nexfin monitor during conditions of reduced arterial pulsatility. During cardiopulmonary bypass (CPB) in which a roller pump based or a centrifugal pump based heart-lung machine generated arterial blood pressure with low pulsatility, noninvasive arterial pressures (NAP) measured by the Nexfin Monitor were recorded and compared with invasively measured radial artery pressures (IAP). We also evaluated NAP in 10 patients with a cf-LVAD during a pump speed change procedure (PSCP). During CPB in 18 patients, the NAP-IAP average difference was -1.3 +/- 6.5 mm Hg. The amplitude of pressure oscillations were 4.3 +/- 3.8 mm Hg measured by IAP. Furthermore, in the cf-LVAD patients, increase in pump speed settings led to an increase in diastolic and mean arterial pressures (MAP) while the NAP acquired a sinusoidal shape as the aortic valve become permanently closed. In conclusion, NAP was similar to IAP under conditions of reduced arterial pulsatility. The device also measured the blood pressure waveform noninvasively in patients supported by a cf-LVAD. ASAIO Journal 2010; 56:221-22

Noninvasive cardiac output monitoring during exercise testing: Nexfin pulse contour analysis compared to an inert gas rebreathing method and respired gas analysis

Exercise testing is often used to assess cardiac function during physical exertion to obtain diagnostic information. However, this procedure is limited to measuring the electrical activity of the heart using electrocardiography and intermittent blood pressure (BP) measurements and does not involve the continuous assessment of heart functioning. In this study, we compared continuous beat-to-beat pulse contour analysis to monitor noninvasive cardiac output (CO) during exercise with inert gas rebreathing and respired gas analysis. Nineteen healthy male volunteers were subjected to bicycle ergometry testing with increasing workloads. Cardiac output was deter- mined noninvasively by continuous beat-to-beat pulse contour analysis (Nexfin) and by inert gas rebreathing, and estimated using the respired gas analysis method. The effects of the rebreathing maneuver on heart rate (HR), stroke volume (SV), and CO were evaluated. The CO values derived from the Nexfin- and inert gas rebreathing methods were well correlated (r = 0.88, P < 0.01) and the limits of agreement were 30.3% with a measurement bias of 0.4 ± 1.8 L/min. Nexfin- and respired gas analysis-derived CO values correlated even better (r = 0.94, P < 0.01) and the limits of agreement were 21.5% with a measurement bias of -0.70 ± 1.6 L/min. At rest, the rebreathing maneuver increased HR by 13 beats/min (P < 0.01), SV remained unaffected (P = 0.7), while CO increased by 1.0 L/min (P < 0.01). Rebreathing did not affect these parameters during exercise. Nexfin continuous beat-to-beat pulse contour analysis is an appropriate method for noninvasive assessment of CO during exercis

Noninvasive arterial blood pressure waveforms in patients with continuous-flow left ventricular assist devices

Arterial blood pressure and echocardiography may provide useful physiological information regarding cardiac support in patients with continuous-flow left ventricular assist devices (cf-LVADs). We investigated the accuracy and characteristics of noninvasive blood pressure during cf-LVAD support. Noninvasive arterial pressure waveforms were recorded with Nexfin (BMEYE, Amsterdam, The Netherlands). First, these measurements were validated simultaneously with invasive arterial pressures in 29 intensive care unit patients. Next, the association between blood pressure responses and measures derived by echocardiography, including left ventricular end-diastolic dimensions (LVEDDs), left ventricular end-systolic dimensions (LVESDs), and left ventricular shortening fraction (LVSF) were determined during pump speed change procedures in 30 outpatients. Noninvasive arterial blood pressure waveforms by the Nexfin monitor slightly underestimated invasive measures during cf-LVAD support. Differences between noninvasive and invasive measures (mean ± SD) of systolic, diastolic, mean, and pulse pressures were -7.6 ± 5.8, -7.0 ± 5.2, -6.9 ± 5.1, and -0.6 ± 4.5 mm Hg, respectively (all <10%). These blood pressure responses did not correlate with LVEDD, LVESD, or LVSF, while LVSF correlated weakly with both pulse pressure (r = 0.24; p = 0.005) and (dP(art)/dt)max (r = 0.25; p = 0.004). The dicrotic notch in the pressure waveform was a better predictor of aortic valve opening (area under the curve [AUC] = 0.87) than pulse pressure (AUC = 0.64) and (dP(art)/dt)max (AUC = 0.61). Patients with partial support rather than full support at 9,000 rpm had a significant change in systolic pressure, pulse pressure, and (dP(art)/dt)max during ramp studies, while echocardiographic measures did not change. Blood pressure measurements by Nexfin were reliable and may thereby act as a compliment to the assessment of the cf-LVAD patien

Noninvasive continuous arterial blood pressure monitoring with Nexfin®

BACKGROUND: If invasive measurement of arterial blood pressure is not warranted, finger cuff technology can provide continuous and noninvasive monitoring. Finger and radial artery pressures differ; Nexfin® (BMEYE, Amsterdam, The Netherlands) measures finger arterial pressure and uses physiologic reconstruction methodologies to obtain values comparable to invasive pressures. METHODS: Intra-arterial pressure (IAP) and noninvasive Nexfin arterial pressure (NAP) were measured in cardiothoracic surgery patients, because invasive pressures are available. NAP-IAP differences were analyzed during 30 min. Tracking was quantified by within-subject precision (SD of individual NAP-IAP differences) and correlation coefficients. The ranges of pressure change were quantified by within-subject variability (SD of individual averages of NAP and IAP). Accuracy and precision were expressed as group average ± SD of the differences and considered acceptable when smaller than 5 ± 8 mmHg, the Association for the Advancement of Medical Instrumentation criteria. RESULTS: NAP and IAP were obtained in 50 (34-83 yr, 40 men) patients. For systolic, diastolic, mean arterial, and pulse pressure, median (25-75 percentiles) correlation coefficients were 0.96 (0.91-0.98), 0.93 (0.87-0.96), 0.96 (0.90-0.97), and 0.94 (0.85-0.98), respectively. Within-subject precisions were 4 ± 2, 3 ± 1, 3 ± 2, and 3 ± 2 mmHg, and within-subject variations 13 ± 6, 6 ± 3, 9 ± 4, and 7 ± 4 mmHg, indicating precision over a wide range of pressures. Group average ± SD of the NAP-IAP differences were -1 ± 7, 3 ± 6, 2 ± 6, and -3 ± 4 mmHg, meeting criteria. Differences were not related to mean arterial pressure or heart rate. CONCLUSION: Arterial blood pressure can be measured noninvasively and continuously using physiologic pressure reconstruction. Changes in pressure can be followed and values are comparable to invasive monitoring