CD30: receptor, marker, target

Susan RS Gottesman,1,21Department of Pathology, 2Department of Cell Biology, SUNY Downstate Medical Center, Brooklyn, NY, USA Abstract: CD30 is a member of the tumor necrosis factor receptor family and is expressed on activated lymphocytes and a few other normal cells. Its signaling activates NF-κB transcription factor, resulting in pleiotropic regulation of gene function. CD30 is the characteristic marker of classical Hodgkin lymphoma, anaplastic large-cell lymphoma, and embryonal cell carcinoma, and it is expressed on a subset of aggressive T- and B-cell neoplasms. Its restricted expression on normal cells makes it an attractive candidate for targeted therapy. The underlying molecular alterations in these malignancies serve to explain the need for a toxin-bound therapeutic reagent. Keywords: NF-κB, Hodgkin lymphoma, TNF-R, ALC