Potential Hypotensive Agents: Synthesis and Hypotensive Activity of Oxime Ethers Derived from 1-Naphthoxepines and Related Compounds.

A series of oxime ethers 1 and 2 have been synthesized and evaluated for their hypotensive activity. The synthesis and pharmacological evaluation of substituted oximino-ethers 1 and 2 of naphth[1,2- b]- and naphth[2,1- b]-oxepin-5-ones ( 4 and 8) were carried out. The hypotensive activity of oximino-ethers 1 and 2 was evaluated on anaesthetized cats. The results indicated that 1c caused a fall of 80 mm/Hg for >100′ at a dose of 5 mg/kg iv in anaesthetized cats

Potential hypotensive agents: synthesis and hypotensive activity of oxime ethers derived from 1-naphthoxepines and related compounds

A series of oxime ethers 1 and 2 have been synthesized and evaluated for their hypotensive activity. The synthesis and pharmacological evaluation of substituted oximino-ethers 1 and 2 of naphth[1,2- b]- and naphth[2,1- b]-oxepin-5-ones ( 4 and 8) were carried out. The hypotensive activity of oximino-ethers 1 and 2 was evaluated on anaesthetized cats. The results indicated that 1c caused a fall of 80 mm/Hg for >100′ at a dose of 5 mg/kg iv in anaesthetized cats