Catabolism of Tetrapyrroles

The enzymatic degradation of naturally occurring tetrapyrrolic pigments (heme, chlorophylls, and vitamin B12) is shortly reviewed

Stereospecific Synthesis of Carbanucleotides Designed for Antisense Methodology

A short stereospecific synthesis of the carbocyclic 2'-deoxynucleoside analogues 36 and 37 (Schemes 2 and 5) and 45 and 46 (Schemes 2 and 6) starting from optically active 8,9,10-trinorborn-5-en-2-one (1) is described. As two functional groups capable to react with each other are present in the same molecule of the synthetic carbanucleosides, the latter can form polymers similar to oligonucleotides

Nutzerzufriedenheit in Bürogebäuden - Eine Feldstudie

Diese Arbeit stellt Ergebnisse von Mitarbeiterbefragungen in 17 Bürogebäuden in Deutschland vor. Die Befragungen fanden am Arbeitsplatz mit Hilfe eines standardisierten Fragebogens statt. Die erfassten Werte zum empfundenen KOmfort am Arbeitsplatz wurden im Zusammenhang mit dem architektonischen und dem energetischen Konzept der Gebäude betrachtet. Zusätzlich wird eine Methode vorgestellt, mit der Optimierungspotentiale im Gebäudebetrieb mit Hilfe von Nutzerbefragungen aufgezeigt werden können

Isolation of the Phytochrome Chromophore. The Cleavage Reaction with Hydrogen Bromide

The cleavage of the bilin chromophore from C-phycocyanin with hydrogen bromide yields 3E-configurated phycocyanobilin (4) as the major and 3 Z-configurated phycocyanobilin (5) as the minor reaction product. The reaction of synthetic 3E-configurated phytochromobilin (2) with hydrogen bromide and methanol leads only to a methanol adduct at the C-18 side chain (7) whereas the same reaction with the 3Z-configurated phytochromobilin (3) leads to 7 and 2. The bilin chromophore was cleaved also from phytochrome after preparation of phytochromobilin peptides. The detection of 2 and 7 suggested that 3Z-and 3E-configurated phytochromobilin were the primary products of cleavage from phytochrome. A reaction scheme is given which can explain the results of the reaction with hydrogen bromide and methanol