4,588 research outputs found
On the Non-Gaussianity Observed in the COBE-DMR Sky Maps
In this paper we pursue the origin of the non-Gaussianity determined by a
bispectrum analysis of the COBE-DMR 4-year sky maps. The robustness of the
statistic is demonstrated by the rebinning of the data into 12 coordinate
systems. By computing the bispectrum statistic as a function of various data
partitions - by channel, frequency, and time interval, we show that the
observed non-Gaussian signal is driven by the 53 GHz data. This frequency
dependence strongly rejects the hypothesis that the signal is cosmological in
origin. A jack-knife analysis of the coadded 53 and 90 GHz sky maps reveals
those sky pixels to which the bispectrum statistic is particularly sensitive.
We find that by removing data from the 53 GHz sky maps for periods of time
during which a known systematic effect perturbs the 31 GHz channels, the
amplitudes of the bispectrum coefficients become completely consistent with
that expected for a Gaussian sky. We conclude that the non-Gaussian signal
detected by the normalised bispectrum statistic in the publicly available DMR
sky maps is due to a systematic artifact. The impact of removing the affected
data on estimates of the normalisation of simple models of cosmological
anisotropy is negligible.Comment: 14 pages, plus 8 Postscript and 3 GIF figures. LaTeX2e document using
AASTeX v5.0 macros. Revised version accepted for publication in the
Astrophysical Journal: small changes to the text, minor modifications to
figures 1 and
The angular power spectrum of radio emission at 2.3 GHz
We have analysed the Rhodes/HartRAO survey at 2326 MHz and derived the global
angular power spectrum of Galactic continuum emission. In order to measure the
angular power spectrum of the diffuse component, point sources were removed
from the map by median filtering. A least-square fit to the angular power
spectrum of the entire survey with a power law spectrum C_l proportional to
l^{-alpha}, gives alpha = 2.43 +/- 0.01 for l = 2-100. The angular power
spectrum of radio emission appears to steepen at high Galactic latitudes and
for observed regions with |b| > 20 deg, the fitted spectral index is alpha =
2.92 +/- 0.07. We have extrapolated this result to 30 GHz (the lowest frequency
channel of Planck) and estimate that no significant contribution to the sky
temperature fluctuation is likely to come from synchrotron at degree-angular
scalesComment: 10 pages, 10 figures, accepted for publication by Astronomy &
Astrophysic
Analysis of CMB foregrounds using a database for Planck
Within the scope of the Planck IDIS (Integrated Data Information System)
project we have started to develop the data model for time-ordered data and
full-sky maps. The data model is part of the Data Management Component (DMC), a
software system designed according to a three-tier architecture which allows
complete separation between data storage and processing. The DMC is already
being used for simulation activities and the modeling of some foreground
components. We have ingested several Galactic surveys into the database and
used the science data-access interface to process the data. The data structure
for full-sky maps utilises the HEALPix tessellation of the sphere. We have been
able to obtain consistent measures of the angular power spectrum of the
Galactic radio continuum emission between 408 MHz and 2417 MHz.Comment: 7 pages, 6 figures. To appear in the Proceedings of the MPA/ESO/MPE
Joint Astronomy Conference "Mining The Sky
CCNE1 Amplification as a Predictive Biomarker of Chemotherapy Resistance in Epithelial Ovarian Cancer
Ovarian cancer is the most-deadly gynecologic malignancy, with greater than 14,000 women expected to succumb to the disease this year in the United States alone. In the front-line setting, patients are treated with a platinum and taxane doublet. Although 40-60% of patients achieve complete clinical response to first-line chemotherapy, 25% are inherently platinum-resistant or refractory with a median overall survival of about one year. More than 80% of women afflicted with ovarian cancer will recur. Many attempts have been made to understand the mechanism of platinum and taxane based chemotherapy resistance. However, despite decades of research, few predictive markers of chemotherapy resistance have been identified. Here, we review the current understanding of one of the most common genetic alterations in epithelial ovarian cancer, CCNE1 (cyclin E1) amplification, and its role as a potential predictive marker of cytotoxic chemotherapy resistance. CCNE1 amplification has been identified as a primary oncogenic driver in a subset of high grade serous ovarian cancer that have an unmet clinical need. Understanding the interplay between cyclin E1 amplification and other common ovarian cancer genetic alterations provides the basis for chemotherapeutic resistance in CCNE1 amplified disease. Exploration of the effect of cyclin E1 amplification on the cellular machinery that causes dysregulated proliferation in cancer cells has allowed investigators to explore promising targeted therapies that provide the basis for emerging clinical trials
LISA data analysis I: Doppler demodulation
The orbital motion of the Laser Interferometer Space Antenna (LISA) produces
amplitude, phase and frequency modulation of a gravitational wave signal. The
modulations have the effect of spreading a monochromatic gravitational wave
signal across a range of frequencies. The modulations encode useful information
about the source location and orientation, but they also have the deleterious
affect of spreading a signal across a wide bandwidth, thereby reducing the
strength of the signal relative to the instrument noise. We describe a simple
method for removing the dominant, Doppler, component of the signal modulation.
The demodulation reassembles the power from a monochromatic source into a
narrow spike, and provides a quick way to determine the sky locations and
frequencies of the brightest gravitational wave sources.Comment: 5 pages, 7 figures. References and new comments adde
Diffraction microtomography with sample rotation: influence of a missing apple core in the recorded frequency space
Diffraction microtomography in coherent light is foreseen as a promising
technique to image transparent living samples in three dimensions without
staining. Contrary to conventional microscopy with incoherent light, which
gives morphological information only, diffraction microtomography makes it
possible to obtain the complex optical refractive index of the observed sample
by mapping a three-dimensional support in the spatial frequency domain. The
technique can be implemented in two configurations, namely, by varying the
sample illumination with a fixed sample or by rotating the sample using a fixed
illumination. In the literature, only the former method was described in
detail. In this report, we precisely derive the three-dimensional frequency
support that can be mapped by the sample rotation configuration. We found that,
within the first-order Born approximation, the volume of the frequency domain
that can be mapped exhibits a missing part, the shape of which resembles that
of an apple core. The projection of the diffracted waves in the frequency space
onto the set of sphere caps covered by the sample rotation does not allow for a
complete mapping of the frequency along the axis of rotation due to the finite
radius of the sphere caps. We present simulations of the effects of this
missing information on the reconstruction of ideal objects.Comment: 7 pages, 11 figures, presented at Focus On Microscopy 200
The shape of the CMB lensing bispectrum
Lensing of the CMB generates a significant bispectrum, which should be
detected by the Planck satellite at the 5-sigma level and is potentially a
non-negligible source of bias for f_NL estimators of local non-Gaussianity. We
extend current understanding of the lensing bispectrum in several directions:
(1) we perform a non-perturbative calculation of the lensing bispectrum which
is ~10% more accurate than previous, first-order calculations; (2) we
demonstrate how to incorporate the signal variance of the lensing bispectrum
into estimates of its amplitude, providing a good analytical explanation for
previous Monte-Carlo results; and (3) we discover the existence of a
significant lensing bispectrum in polarization, due to a previously-unnoticed
correlation between the lensing potential and E-polarization as large as 30% at
low multipoles. We use this improved understanding of the lensing bispectra to
re-evaluate Fisher-matrix predictions, both for Planck and cosmic variance
limited data. We confirm that the non-negligible lensing-induced bias for
estimation of local non-Gaussianity should be robustly treatable, and will only
inflate f_NL error bars by a few percent over predictions where lensing effects
are completely ignored (but note that lensing must still be accounted for to
obtain unbiased constraints). We also show that the detection significance for
the lensing bispectrum itself is ultimately limited to 9 sigma by cosmic
variance. The tools that we develop for non-perturbative calculation of the
lensing bispectrum are directly relevant to other calculations, and we give an
explicit construction of a simple non-perturbative quadratic estimator for the
lensing potential and relate its cross-correlation power spectrum to the
bispectrum. Our numerical codes are publicly available as part of CAMB and
LensPix.Comment: 32 pages, 10 figures; minor changes to match JCAP-accepted version.
CMB lensing and primordial local bispectrum codes available as part of CAMB
(http://camb.info/
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