Representation and Misrepresentation in Biomolecular Science

Biological molecules are too small for direct imaging, so synthetic images are used for study and presentation of molecular structure. Three basic types of images are widely used, using different fictional elements to display different aspects of the structure: bond diagrams represent each covalent bond as a single line; spacefilling diagrams represent each atom as a sphere; and ribbon diagrams are schematic representations of the molecular topology. The widespread, and nearly exclusive, use of these three types of diagrams has influenced the course of biomolecular research and the perception of molecules in the popular media

Optimising the NAOMI adaptive optics real-time control system

This thesis describes the author's research in the field of Real-Time Control (RTC) for Adaptive Optics (AO) instrumentation. The research encompasses experiences and knowledge gained working in the area of RTC on astronomical instrumentation projects whilst at the Optical Science Laboratories (OSL), University College London (UCL), the Isaac Newton Groups of Telescopes (ING) and the Centre for Advanced Instrumentation (СfAI), Durham University. It begins by providing an extensive introduction to the field of Astronomical Adaptive Optics covering Image Correction Theory, Atmospheric Theory, Control Theory and Adaptive Optics Component Theory. The following chapter contains a review of the current state of world wide AO instruments and facilities. The Nasmyth Adaptive Optics Multi-purpose Instrument (NAOMI), the common user AO facility at the 4.2 William Herschel Telescope (WHT), is subsequently described. Results of NAOMI component characterisation experiments are detailed to provide a system understanding of the improvement optimisation could offer. The final chapter investigates how upgrading the RTCS could increase NAOMI'S spatial and temporal performance and examines the RTCS in the context of Extremely Large Telescope (ELT) class telescopes

Historical configuration of habitat influences the effects of disturbance on mobile invertebrates

Copyright © 2005 Inter-Research.Mobile animals can be affected by disturbance because of changes to the structure of their habitat. Few studies, however, recognise the potential for the historical configuration of habitat (e.g. density prior to disturbance) to affect the way animals respond to the disturbance. Furthermore, there is a tendency for ecologists to study or manipulate only the most severe disturbances, but such events are less likely to be common. We tested the hypothesis that the density of Ecklonia radiata before disturbance affects the response of assemblages of mobile invertebrates to different severities of disturbance. Differences in the severity of disturbance caused changes in the structure of assemblages, but this response varied depending on the historical configuration of habitat. The magnitude by which assemblage structure differed between undisturbed and disturbed habitats was greater where habitats were historically sparse rather than dense. We emphasise the importance of assessing a range of severities of disturbance and demonstrate the importance of habitat configuration prior to the disturbance, particularly for animals with close association to their habitat.Paris J. Goodsell and Sean D. Connel

MOLECULE OF THE MONTH:

Our diet includes a wide variety of different molecules. Many of these molecules are broken down completely and used to generate the metabolic energy that powers our cells. Others are disassembled piece-by-piece and recycled to build our own proteins and nucleic acids. The ones that are left over are broken down and discarded. Xanthine oxidoreductase, shown here from PDB entry 1fo4, is the last stop for extra purine nucleotides (ATP and GTP) in our cells. Purines are broken down in several steps, ultimately yielding uric acid, which is excreted from the body. About the RCSB PDB Molecule of the Month Using selected molecules from the PDB archive, each feature includes an introduction to the structure and function of the molecule, a discussion of its relevance to human health and welfare, and suggestions for viewing and accessing further details. The RCSB PDB Molecule of the Month is read by students, teachers, and scientists worldwide at www.pdb.org

Dark Matter and Dark Forces from a supersymmetric hidden sector

We show that supersymmetric "Dark Force" models with gravity mediation are viable. To this end, we analyse a simple string-inspired supersymmetric hidden sector model that interacts with the visible sector via kinetic mixing of a light Abelian gauge boson with the hypercharge. We include all induced interactions with the visible sector such as neutralino mass mixing and the Higgs portal term. We perform a detailed parameter space scan comparing the produced dark matter relic abundance and direct detection cross sections to current experiments.Comment: 40 pages, 11 figures comprising 21 plots. 4Mb total size. v2: figures and references updated; typos removed; some extra explanations added. Matches version published in PR

Visualising microorganisms from molecules to cells

10 images from FEMS articles have been selected to show the diversity of visualisation used in microbiolog

Filling in the Gaps: Artistic License in Education and Outreach

Conscious and careful application of artistic license is an essential part of the creation of scientific illustrations for research, education, and science outreach

Promoting a structural view of biology for varied audiences: an overview of RCSB PDB resources and experiences

The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB) serves a community of users with diverse backgrounds and interests. In addition to processing, archiving and distributing structural data, it also develops educational resources and materials to enable people to utilize PDB data and to further a structural view of biology

A Three-dimensional Printed Low-cost Anterior Shoulder Dislocation Model for Ultrasound-guided Injection Training.

Anterior shoulder dislocations are the most common, large joint dislocations that present to the emergency department (ED). Numerous studies support the use of intraarticular local anesthetic injections for the safe, effective, and time-saving reduction of these dislocations. Simulation training is an alternative and effective method for training compared to bedside learning. There are no commercially available ultrasound-compatible shoulder dislocation models. We utilized a three-dimensional (3D) printer to print a model that allows the visualization of the ultrasound anatomy (sonoanatomy) of an anterior shoulder dislocation. We utilized an open-source file of a shoulder, available from embodi3D® (Bellevue, WA, US). After approximating the relative orientation of the humerus to the glenoid fossa in an anterior dislocation, the humerus and scapula model was printed with an Ultimaker-2 Extended+ 3D® (Ultimaker, Cambridge, MA, US) printer using polylactic acid filaments. A 3D model of the external shoulder anatomy of a live human model was then created using Structure Sensor®(Occipital, San Francisco, CA, US), a 3D scanner. We aligned the printed dislocation model of the humerus and scapula within the resultant external shoulder mold. A pourable ballistics gel solution was used to create the final shoulder phantom. The use of simulation in medicine is widespread and growing, given the restrictions on work hours and a renewed focus on patient safety. The adage of see one, do one, teach one is being replaced by deliberate practice. Simulation allows such training to occur in a safe teaching environment. The ballistic gel and polylactic acid structure effectively reproduced the sonoanatomy of an anterior shoulder dislocation. The 3D printed model was effective for practicing an in-plane ultrasound-guided intraarticular joint injection. 3D printing is effective in producing a low-cost, ultrasound-capable model simulating an anterior shoulder dislocation. Future research will determine whether provider confidence and the use of intraarticular anesthesia for the management of shoulder dislocations will improve after utilizing this model

Redox-Based Probes for Protein Tyrosine Phosphatases

No AbstractPeer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/83769/1/4423_ftp.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/83769/2/anie_201007871_sm_miscellaneous_information.pd